Education Background：

2005~2009 Beijing Institute of Technology
Bioengineering, Bachelor
2009~2015 Peking University
Physiology, PhD, Mentor: Professor Shi-Qiang Wang

Work Experience：

2015~2019 New York University Langone Medical Center, Postdoctoral Research Fellow, Mentor: Professor William Coetzee
2019~2020 New York University Langone Medical Center, Research Assistant Professor, Assistant Director of Electrophysiology Core
2021~now Cyrus Tang Medical Institute, Soochow University
Professor, PhD supervisor

Research Direction:

The Cardiovascular Electrophysiology Research Group uses patch clamp techniques to study the function of ion channels in the cardiovascular system and related cardiovascular diseases. The main research directions include:
1) Gene therapy of cardiac ion channelopathy.
2) Identification of novel ion channels and their in vivo functions.
3) ATP-sensitive potassium channel trafficking and cardioprotection.

Representative Publication：(* corresponding author, # equal contribution)

1.Huo JY, Feng YL, Chen YT, Yang B, Zhi YT, Wang HJ, Yang HQ*. Caveolin-3 negatively regulates endocytic recycling of cardiac KATP channels. Am J Physiol Cell Physiol. 2023 Oct 1;325(4):C1106-C1118.
2.Yang B, Yao JL, Huo JY, Feng YL, Coetzee WA, Xu GY*, Yang HQ*. Rab35 GTPase positively regulates endocytic recycling of cardiac KATP channels. Channels (Austin). 2022 Dec;16(1):137-147.
3.Yang HQ, Echeverry FA, ElSheikh A, Gando I, Anez Arredondo S, Samper N, Cardozo T, Delmar M, Shyng SL, Coetzee WA*. Subcellular trafficking and endocytic recycling of KATP channels. Am J Physiol Cell Physiol. 2022 Jun 1;322(6):C1230-C1247.
4.Yang HQ#, Zhou P#, Wang LP#, Zhao YT, Guo YB, Xu, M, Wang SQ*. Compartmentalized β1-adrenergic signaling synchronizes excitation-contraction coupling without modulating individual Ca2+ sparks in healthy and hypertrophied cardiomyocytes. Cardiovasc Res. 2020 Nov 1;116(13):2069-2080.
5.Yang HQ, Martinez-Ortiz W, Hwang J, Fan X, Cardozo TJ, Coetzee WA*. Palmitoylation of the KATP channel Kir6.2 subunit promotes channel opening by regulating PIP2 sensitivity. Proc Natl Acad Sci U S A. 2020 May 12;117(19):10593-10602.
6.Yang HQ, Pérez-Hernández M, Sanchez Alonso JL, Shevchuk A, Gorelik J, Rothenberg E, Delmar M, Coetzee WA*. Ankyrin-G Mediates Targeting of both Na+ and KATP Channels to the Cardiac Intercalated Disc. eLife. 2020 Jan 14;9:e52373.
7.Yang HQ#, Wang LP#, Gong YY#, Fan XX#, Zhu SY#, Wang XT, Wang YP, Li LL, Xing X, Liu XX, Ji GS, Hou TT, Zhang Y, Xiao RP, Wang SQ*. β2-Adrenergic Stimulation Compartmentalizes β1 Signaling into Nanoscale Local Domains by Targeting the C-Terminus of β1-Adrenoceptors. Circ Res. 2019 Apr 26;124(9):1350-1359.
8.Yang HQ, Jana K, Rindler MJ, Coetzee WA*. The trafficking protein, EHD2, positively regulates cardiac sarcolemmal KATP channel surface expression: role in cardioprotection. FASEB J. 2018 Mar;32(3):1613-1625.
9.Yang HQ, Foster MN, Jana K, Ho J, Rindler MJ, Coetzee WA*. Plasticity of sarcolemmal KATP channel surface expression: relevance during ischemia and ischemic preconditioning. Am J Physiol Heart Circ Physiol. 2016 Jun 1;310(11):H1558-66.

Academic Association：

1.Committee member of Chinese Association for Physiological Sciences
2.Youth committee member of Biophysical Society of China
3.Youth editor of Biophysics Reports