Dr. Wang received his Ph.D. degree in 1997 from the Institute of Biochemistry Chinese Academy of Sciences, Shanghai, China. He started to work at Cornell University, Ithaca, New York, USA with major research interest in experimental hematology in 1999 and moved back to Soochow University, Suzhou, China in 2010, where he served as a vice dean of Medical College. Dr. Wang is currently the director and professor of the Research Center for Blood Engineering and Manufacturing of Soochow University. He is also a principle investigator at Cyrus Tang Medical Institute of Soochow University and holds adjunct professorship at National Research Center for Hematological Diseases and National Key Laboratory for Radiation Medicine and Protection, Suzhou, China. His lab has been studying the cascades of aging-driven initiation of hematopoietic oncogenesis and autophagy-dependent intervention on hematopoietic aging progression, in particular with nonmedical endeavors based on traditional Chinese health practice such as short-term intensive fasting, known as beego. The ultimate goal of his study is to define and prevent the predisease for hematological malignancies initiated from the transformation of hematopoietic stem and progenitor cells in the bone marrow. His research also includes engineering and manufacturing of hematopoietic stem cells and functional blood cells with a longer storage lifespan but without allogeneic immune rejection for clinical use through in vitro modification of immune, aging and survival pathways in immortalized hematopoietic stem and progenitor cells and induced pluripotent stem cells.

 

Team members

 

Junior investigator

Suping Zhang, Ph.D., Associate Investigator

Na Yuan, Ph.D.,  Associate Investigator

Yixuan Fang, Ph.D., Lecturer

Postdoctoral Fellow

Wen Wei, Ph.D.                                                                                                                                                                                        

Graduate Students

Lei Li, Ph.D. student              

Xueqin Gao, Ph.D. student

Chen Zhao, Ph.D. student

Di Zhang, Ph.D. student

Ruizhi Zhang, MD student

Jiajun Zhang, MD student

Xueqin Wang, Master student

Zhenzhen Liu, Master student

Jin Dong, Master student

Bowen Liu, Master student

Yao Yu, Master student

Yumu Zhang, Master student

Jiiarong Wang, Master student

Meilin Lu, Master student    

Undergraduate Students

Jiawei Qian, Quan Li, Zhenzhen Zhao, Hao Huang

    

Funding  (since joining Soochow University in March 2010)

1. Autophagic regulation of the stemness of hematopoietic stem cells

National Natural Science Foundation of China (Beijing, CN)

GRANT_NUMBER: 31071258

2. The autophagy of hematopoietic stem cells in counteracting the initiation of blood malignancies

National Natural Science Foundation of China (Beijing, CN)

GRANT_NUMBER: 81272336

3. Exploring the novel role of Beclin 1 independent on autophagy pathway

National Natural Science Foundation of China (Beijing, CN)

GRANT_NUMBER: 31271526

4. Mechanistic study on the prevention and treatment of major diseases in China

Ministry of Science and Technology of the People's Republic of China (Beijing, CN)

GRANT_NUMBER: 2011CB512100

5. Mechanistic study on the prevention of hematopoietic stem cell transformation

Ministry of Science and Technology of the People's Republic of China (Beijing, CN)

GRANT_NUMBER: 2011CB51201

6. Bafilomycin A1 in the treatment of CNS leukemia of children

National Natural Science Foundation of China (Beijing, CN)

GRANT_NUMBER: 81570126

7. Autophagy in the regulation of hematopoietic aging

National Natural Science Foundation of China (Beijing, CN)

GRANT_NUMBER: 91649113

8. Notch-SIRT7-H3 axis in autophagic regulation of multilineage differentiation of hematopoietic stem cells

National Natural Science Foundation of China (Beijing, CN)

GRANT_NUMBER: 31771640

9. Mitophagy in regulating platelet storage lifespan

National Natural Science Foundation of China (Beijing, CN)

GRANT_NUMBER: 82170227

10. Hyperradioactive Beclin1 as a dual target for tumor radiosensitization or radioprotection

State Key Laboratory of Radiation Medicine and Protection at Soochow University (Suzhou, CN)

GRANT_NUMBER: GZC00201

11. Generation of universal human platelets

Suzhou Local Government (Suzhou, CN)

GRANT_NUMBER: WC202138

 

Recent Publications 

1.   Fang Y, Qian J, Xu L, Wei W, Bu W, Zhang S, Lv Y, Li L, Zhao C, Gao X, Gu Y, Wang L, Chen  Z, Wang X, Zhang R, Xu Y, Yang Y, Yan Z, Wang M, Tang L, Yuan N, Wang J. Short-term intensive fasting enhances the immune function of red blood cells in humans. Immunity & Ageing 2023;20(44). doi:10.1186/s12979-023-00359-3.

2.   Na Yuan, Wen Wei, Li Ji, Jiawei Qian, Zhicong Jin, Hong Liu, Li Xu. Lei Li, Chen Zhao, Xueqin Hao, Yulong He, Mingyuan Wang, Longhai Tang, Yixuan Fang, Jianrong Wang. Young doonor hematopoietic stem cells revitalize aged or damaged bone marrow niche by transdifferentiating into functional niche cells. Aging Cell 2023;22(5);e13889. doi:10.1111/acel.13889

3.   Qian J, Fang Y, Yuan N, Gao X, Lv Y, Zhao C, Zhang S, Li Q, Li L, Xu L, Wei W, Wang J. Innate immune remodeling by short-term intensive fasting. Aging Cell 2021;20(11):e13507. doi:10.1111/acel.13507.

4.   Li L Y, Zhang S, Ge C, Ji L, Lv Y, Zhao C, Xu L, Zhang J, Song C, Chen J, Wei W, Fang Y, Yuan N, Wang J. HSCs transdifferentiate primarily to pneumonocytes in radiation-induced lung damage repair. Aging 2021;13(6):8335-8354. doi:10.18632/aging.202644.

5.   Fang Y, Gu Y, Zhao C, Lv Y, Qian J, Zhu L, Yuan N, Zhang S, Wang L, Li M, Zhang Q, Xu L, Wei W, Li L, Ji L, Gao X, Zhang J, Shen Y, Chen Z, Wang G, Dai K, Wang J. Impact of supervised beego, a triditinal Chinese water-only fasting, on thrombosis and haemostasis. BMJ Nutrition, Prevention & Health 2021;4(1):4-17. doi:10.1136/bmjnph-2020-000183.

6.   Fang Y, Gu Y, Li L, Qian J, Zhao C, Xu L, Wei W, Du Y, Yuan N, Zhang S, Yuan Y, Xu Y, Jiang C, Wang J. Loss of Atg7 causes chaotic nucleosome assembly of mouse bone marrow CD11b+Ly6G-myeloid cells. Aging 2020;12(24):25673-83. 

7.   Fang Y, An N, Zhu L, Gu Y, Qian J, Jiang G, Zhao R, Wei W, Xu L, Zhang G, Yao X, Yuan N, Zhang S, Zhao Y, Wang J. Autophagy-Sirt3 axis decelerates hematopoietic aging. Aging Cell 2020; 19:e13232. doi: 10.1111/acel.13232.  

8.   Yuan Y, Fang Y, Zhu L, Gu Y, Li L, Qian J, Zhao R, Zhang P, Li J, Zhang H, Yuan N, Zhang S, Ma Q, Wang J, Xu Y. Deterioration of hematopoietic autophagy is linked to osteoporosis. Aging Cell 2020; 19:e13114. doi: 10.1111/acel.13114.

9.   Xu L, Yuan N, Liu H, Fang Y, Ge C, Xu F, An N, Wei W, Li L, Ji L, Zhang X, Meng J, Zhang S, Zhao Y, Chen Z, Chen S, Wu D, Wang J. Bafilomycin A1 targets patient-derived CD34CD19 leukemia stem cells. Haematologica 2020; 105(1):e17-e21.

10.  Fang Y, Zhu L, An N, Jiang G, Zhao R, Qian J, Yuan, N, Zhang S, Wang J. Blood autophady defect causes non-hematopoietic organ aging. Aging 2019; 11(14):4910-4922.

11. Zhang Y, Yao Y, Qiu X, Wang G, Hu Z, Chen S, Wu Z, Yuan N, Gao H, Wang J, Song H, Girardin SE, Qian Y. Listeria hijacks host mitophagy through a novel mitophagy receptor to evade killing. Nature Immunology 2019; 20:433-446.   

12. Wang ZT, Lu MH, Zhang Y, Ji WL, Lei L, Wang W, Fang LP, Wang LW, Yu F, Wang J, Li ZY, Wang JR, Wang TH, Dou F, Wang QW, Wang XL, Li S, Ma QH, Xu RX. Disrupted-in-schizophrenia-1 protects synaptic plasticity in a transgenic mouse model of Alzheimer's disease as a mitophagy receptor. Aging Cell 2019; 18:e12860. doi: 10.1111/acel.12860.

13. Zhang X, Zhang S, Liu X, Wang Y, Chang J, Zhang X, Mackintosh SG, Tackett AJ, He Y, Lv D, Laberge RM, Campisi J, Wang J, Zheng G, Zhou D. Oxidation resistance 1 is a novel senolytic target. Aging Cell 2018; 17:e12780. doi: 10.1111/acel.12780.

14. Xu F, Fang Y, Yan L, Xu L, Zhang S, Cao Y,  Xu L, Zhang X,  Xie J, Jiang G, Ge C, An N, Zhou D, Yuan N,  Wang J.  Nuclear localization of Beclin 1 promotes radiation-induced DNA damage repair independent of autophagy. Scientific Reports  2017; 7:45385; doi: 10.1038/srep45385. Pubmed

15. Xu F, Li X, Yan L, Yuan N, Fang Y, Cao Y, Xu L, Zhang X, Xu L,Ge C,An N, Jiang G, Xie J, Zhang H, Zhang J,Li X,Yao L,Zhang S, Zhou D, Wang J. Autophagy promotes the repair of radiation-induced DNA damage in bone marrow hematopoietic cells via enhanced STAT3 signaling. Radiation Research 2017; 187(3):382-396. Pubmed 

16. Wang J, Fang Y, Yan L, Yuan N, Zhang S, Xu L, Nie M,Zhang X, Wang J. Erythroleukemia cells acquire an alternative mitophagy capability. Scientific Reports 2016; 6:24641. doi: 10.1038/srep24641. Pubmed

17. Cao Y,  Fang Y,  Cai J,  Li X,  Xu F,  Yuan N,  Zhang S,  Wang J.  ROS  functions  as  an  upstream  trigger for autophagy to drive hematopoietic stem cell differentiation. Hematology 2016; 21(10):613-618. Pubmed

18. Cao Y, Zhang S, Yuan  N, Wang J, Li X, Xu F, Lin W, Song L, Fang Y, Wang Z, Wang Z, Zhang H, Zhang Y, Zhao W, Hu S, Zhang X, Wang J.  Hierarchal autophagic divergence of hematopoietic system. Journal of Biological Chemistry 2015; 290(49):23050-23063. Pubmed

19. Lin W, Yuan N, Wang Z, Cao Y, Fang Y, Li X, Xu F, Song L, Wang J, Zhang H, Yan L, Xu L, Zhang X, Zhang S, Wang J. Autophagy confers DNA damage repair pathways to protect the hematopoietic system from nuclear radiation injury. Scientific Reports 2015; 5:12362. doi: 10.1038/srep12362. Pubmed

20. Cao Y, Cai J, Zhang S, Yuan N, Fang Y, Wang Z, Li X, Cao D, Xu F, Lin W, Song L, Xu X, Zhang Y, Zhao W, Hu S, Zhang X, Wang J. Autophagy sustains hematopoiesis through targeting Notch. Stem Cell & Development  2015; 24(22):2660-2673. Pubmed

21. Yuan N, Song L, Zhang S, Lin W, Cao Y, Xu F, Fang Y, Wang Z, Zhang H, Li X, Wang ZJ, Cai J, Wang J, Zhang Y, Mao X, Zhao W, Hu S, Chen S, Wang J. Bafilomycin A1 targets both autophagy and apoptosis pathways in pediatric B-cell acute lymphoblastic leukemia. Haematologica 2015; 100(3):345-356. Pubmed

22. Cao Y, Cai J, Zhang S, Yuan N, Li X, Fang Y, Song L, Shang M, Liu S, Zhao W, Hu S, Wang J. Loss of autophagy leads to failure in megakaryopoiesis, megakaryocyte differentiation and thrombopoiesis in mice. Experimental Hematology 2015; 43(6):488-494. (Highlighted paper) Pubmed

23. Yuan N, Song L, Lin W, Cao Y, Xu F, Liu S, Zhang A, Wang Z, Li X, Fang Y, Zhang H, Zhao W, Hu S, Wang J, Zhang S. Autophagy collaborates with ubiquitination to downregulate oncoprotein E2A/Pbx1 in B-cell acute lymphoblastic leukemia. Blood Cancer Journal  2015; 5:e274; doi:10.1038/bcj.2014.96. Pubmed

24. Cao Y, Zhang A, Cai J, Yuan N,  Lin W, Liu S, Xu F, Lin S, Fang Y, Wang Z, Wang ZZ, Wang J, Zhang H, Zhao W, Hu S, Zhang S, Wang J. Autophagy regulates the cell cycle of mouse HSPCs in a nutrient-dependent manner. Experimental Hematology 2015; 43(3):229-242. (Highlighted paper) Pubmed

25. Pang L, Liang Y, Pan J, Wang J, Chai Y, Zhao W. Clinical features and prognostic significance of TCF3-PBX1 fusion gene in Chinese children with acute lymphoblastic leukemia by using a modified ALL-BFM-95 protocol. Pediatric Hematology and Oncology 2015; 32(3):173-81. Pubmed

26. Wang Z, Xu F, Yuan N, Niu Y, Lin W, Cao Y, Cai J, Song L, Li X, Fang Y, Zhao W, Hu S, Chen S, Zhang S, Wang J. Rapamycin inhibits pre-B acute lymphoblastic leukemia cells by downregulating DNA and RNA polymerases. Leukemia Research 2014; 38(5):940-947. Pubmed

27. Cao B, Li J, Zhou X, Juan J, Han K, Zhang Z, Kong Y, Wang J, Mao X. Clioquinol induces pro-death autophagy in leukemia and myeloma cells by disrupting the mTOR signaling pathway. Scientific Reports 2014; 4:5749. Pubmed

28.  Zhang Y, Yang WQ, Zhu H, Qian YY, Zhou L, Ren YJ, Ren XC, Zhang L, Liu XP, Liu CG, Ming ZJ, Li B, Chen B, Wang J, Liu YB, Yang JM. Regulation of autophagy by miR-30d impacts sensitivity of anaplastic thyroid carcinoma to cisplatin. Biochemical Pharmacology 2014; 87(4):562-70. Pubmed

29. Niu Y, Liu Q,  Zhang S, Yuan N, Cao Y, Cai J, Lin W, Xu F,  Wang Z, Chen B, Wang J.  Alternative messenger RNA splicing of autophagy gene beclin1 in human B-cell acute lymphoblastic leukemia cells. Asian and Pacific Journal of Cancer Prevention 2014; 15(5):2153-8. Pubmed

30. Liu XY, Zhang L, Wu J, Zhou L, Ren YJ, Yang WQ, Ming ZJ, Chen B, Wang J, Zhang Y, Yang JM. Inhibition of elongation factor-2 kinase augments the antitumor activity of Temozolomide against glioma. PloS One 2013; 8:e81345. Pubmed

31. Zhang S, Wen G, Huang SX,  Wang J, Tong J,  Hei TK.  Mitochondrial alteration in malignantly transformed human small airway epithelial cells induced by α-particles. International Journal of Cancer 2013; 132(1):19-28. Pubmed

32. Zhang Y, Cheng Y, Ren X, Hori T, Huber-Keener KJ, Zhang L, Yap KL, Liu D, Shantz L, Qin ZH, Zhang S,Wang J, Wang HG, Shih IM, Yang JM. Dysfunction of nucleus accumbens-1 activates cellular senescence and inhibits tumor cell proliferation and oncogenesis. Cancer Research 2012; 72(16):4262-4275. Pubmed

 

Welcome to Wang Lab 

     We are always welcoming applications from prospective undergraduates, graduate students, postdocs and visiting scientists. Creative, interactive but independent, and highly motivated individuals are in particular invited to apply.  If interested, please send your CV or write to jrwang@suda.edu.cn