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2015年8月至今: 18新利体育 心血管病研究所 副教授、硕士研究生导师 2020年5月至2023年6月: 18新利体育 苏州医学院心血管研究所支部委员会 党支部书记 2012年1月至2014年2月: 美国 North Carolina State University 博士后助理研究员 2008年9月至2011年6月: 武汉理工大学材料科学与工程学院 工学博士 2009年9月至2011年6月: 中国科学院苏州纳米技术与纳米仿生研究所 访问学生 2005年9月至2008年6月: 武汉理工大学材料科学与工程学院 工学硕士 2006年10月至2007年9月: 加拿大McMaster University 访问学者 2001年9月至2005年6月: 武汉理工大学化学工程学院 工学学士 基金
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职称:副教授 院部/部门:18新利体育 心血管病研究所 学历:博士 学位:博士 毕业学校:武汉理工大学 毕业专业:生物材料学 联系方式
通讯地址:干将东路178号18新利体育 北校区机物楼407 邮政编码: 电子邮箱:zhangyanxia@suda.edu.cn 联系电话:0512-67781961 传真号码: 办公地点:18新利体育 心血管病研究所 18新利备用网站
1. 小口径人工血管兔子颈动脉置换 2.控释功能因子的可注射水凝胶治疗心梗 3.功能性补片治疗心梗 科研团队
属于沈振亚教授团队: 论文
一、入职苏大后发表SCI论文 (40篇,2015.08——至今)1. 2024年发表文章1)X. Wang, J. Wang, Y. Zhang*, Y. Yu*, Z. Shen*, A fibrin patch loaded with mesenchymal stem cells-derived exosomes improves cardiac functions after myocardial infarction. Colloid and Interface Science Communications, 2024, 59, 100775. 2)H. Zhang, Y. Zou, K. Lu, Y. Wu, Y. Lin, J. Cheng, C. Liu, H. Chen, Y. Zhang* and Q. Yu*, A nanoplatform with oxygen self-supplying and heat-sensitizing capabilities enhances the efficacy of photodynamic therapy in eradicating multidrug-resistant biofilms, Journal of Materials Science & Technology, 2024, 169: 209-219. 2. 2023年发表文章1)Y. Wang, J. Wang, C. Liu, J. Li, K. Lu, Q. Yu*, Y. Zhang*, Z. Shen*, Injectable decellularized extracellular matrix hydrogel loaded with exosomes encapsulating curcumin for prevention of cardiac fibrosis after myocardial infarction, Journal of Materials Science & Technology, 2023, 167, 50–58. 2)Y. Lin, K. Lu, H. Zhang, Y. Zou, H. Chen, Y. Zhang*, Q. Yu*, Multifunctional coatings based on candle soot with photothermal bactericidal property and desired bifunctionality, Journal of Colloid and Interface Science, 2023, 649, 986–995. 3)D. Jia, Y. Lin, Y. Zou, Y. Zhang,* Q. Yu*, Recent Advances in Dual-Function Superhydrophobic Antibacterial Surfaces, Macromolecular Bioscience, 2023, 2300191. 4)Y. Wu, D. Jia, K. Lu, H. Zhang, C. Liu, Y. Lin, J. Cheng, Y. Zou, H. Xu, H. Chen, Y. Zhang* and Q. Yu*, Bacterial cellulose-based dressings with photothermal bactericidal activity and pro-angiogenic ability for infected wound healing, Journal of Materials Science & Technology, 2023, 160: 76-85. 5)J Yuan#, H Yang#, C Liu, L Shao, H Zhang, K Lu, J Wang, Y Wang, Q Yu*,Y Zhang*, Y Yu*, Z Shen*, Microneedle Patch Loaded with Exosomes Containing microRNA-29b Prevents Cardiac Fibrosis after Myocardial Infarction, Advanced Healthcare Materials, 2023,2202959. 6)K Wu, Y Wang, H Yang, Y Chen, K Lu, Y Wu, C Liu, H Zhang, H Meng, Q Yu*, Y Zhang*, Z Shen*, SDF-1-Loaded Injectable Decellularized Extracellular Matrix Hydrogel Promotes Transplanted Cardiomyocyte Engraftment and Functional Regeneration after Myocardial Infarction, ACS Applied Materials &Interfaces 2022,15(2):2578-2589. 7)C Liu#, Y Wu#, H Yang, K Lu, H Zhang, Y Wang, J Wang, L Ruan, Z Shen*, Q Yu*,Y Zhang*. An Injectable Alginate/Fibrin Hydrogel Encapsulated with Cardiomyocytes and VEGF for Myocardial Infarction Treatment. Journal of Materials Science & Technology, 2023, 143:198-206. 8)Y. Lin, H. Zhang, Y. Zou, K. Lu, L. Li, Y. Wu, J. Cheng, Y. Zhang*, H. Chen and Q. Yu*, Superhydrophobic photothermal coatings based on candle soot for prevention of biofilm formation, Journal of Materials Science & Technology, 2023, 132: 18-26. 3. 2022年发表文章1)Y Zou, C Liu, H Zhang, Y Wu, Y Lin, Ji Cheng, K Lu, L Li, Y Zhang*, H Chen, Q Yu*, A Multifunctional Coating with Anti-Adhesion, Bacteria-Killing and Anti-Quorum Sensing Properties for Preventing Biofilm Formation of Pseudomonas aeruginosa, Acta Biomaterialia, 2022, 151: 254-263. 2)K Lu#, Y Qu#, Y Lin, L Li, Y Wu, Y Zou, T Chang, Y Zhang*, Q Yu* and H Chen*, Photothermal Nanoplatform with Sugar-Triggered Cleaning Ability for High-Efficiency Intracellular Delivery. ACS Appl. Mater. Interfaces 2022, 14(2): 2618-2628. 3)L. Li, G. Li, Y. Wu, Y. Lin, Y. Qu, Y. Wu, K. Lu, Y. Zou, H. Chen, Q. Yu* and Y. Zhang*, Dual-functional bacterial cellulose modified with phase-transitioned proteins and gold nanorods combining antifouling and photothermal bactericidal properties, Journal of Materials Science & Technology, 2022. 110: 14-23. 4)Y. Qu#, K. Lu#, Y. Zheng, C. Huang, G. Wang*, Y. Zhang* and Q. Yu*, Photothermal scaffolds/surfaces for regulation of cell behaviors, Bioactive materials, 2022, 8: 449-477. 4. 2021年发表文章2)Y. Zou, K. Lu, Y. Lin, Y. Wu, Y. Wang, L. Li, C. Huang, Y. Zhang*, J. L. Brash, H. Chen and Q. Yu*, Dual-Functional Surfaces Based on an Antifouling Polymer and a Natural Antibiofilm Molecule: Prevention of Biofilm Formation without Using Biocides, ACS Applied Materials & Interfaces, 2021, 13(38): 45191-45200. 3)T. Wei#, Y. Qu#, Y. Zou, Y. Zhang* and Q. Yu*, Exploration of smart antibacterial coatings for practical applications, Current Opinion in Chemical Engineering, 2021, 34: 100727. 5)Y. Zou, Y. Zhang*, Q. Yu*, H. Chen, Dual-function antibacterial surfaces to resist and kill bacteria: painting a picture with two brushes simultaneously, Journal of Materials Science & Technology, 2021, 70:24-38. 6)Y. Wu, T. Chang, W. Chen, X. Wang, J. Li, Y. Chen, Y. Yu, Z. Shen∗, Q. Yu∗, Y. Zhang∗, Release of VEGF and BMP9 from injectable alginate based composite hydrogel for treatment of myocardial infarction. Bioactive materials 2021, 6(2), 520-528. 7)Y. Zou, Y. Zhang*, Q. Yu*, H. Chen, Photothermal bactericidal surfaces: killing bacteria using light instead of biocides. Biomaterials science 2021, 9, 10-22. 5. 2020年发表文章1)Y. Zhou, Y. Zheng, T. Wei, Y. Qu, Y. Wang, W. Zhan, Y. Zhang, G. Pan, D. Li*, Q. Yu* and H. Chen, Multistimulus Responsive Biointerfaces with Switchable Bioadhesion and Surface Functions, ACS Applied Materials & Interfaces, 2020, 12(5): 5447-5455. 2)Y. Wang, T. Wei, Y. Qu, Y. Zhou, Y. Zheng, C. Huang, Y. Zhang, Q. Yu* and H. Chen, Smart, Photothermally Activated, Antibacterial Surfaces with Thermally Triggered Bacteria-Releasing Properties, ACS Applied Materials & Interfaces, 2020, 12(19): 21283-21291. 3)Y. Qu#, Y. Zhang#, Q. Yu*, H. Chen, Surface-Mediated Intracellular Delivery by Physical Membrane Disruption. ACS Applied Materials & Interfaces 2020, 12(28) 31054–31078. 4)Y. Zheng, Y. Wu, Y. Zhou, J. Wu, X. Wang, Y. Qu, Y. Wang, Y. Zhang*, Q. Yu*. Photothermally Activated Electrospun Nanofiber Mats for High-Efficiency Surface-Mediated Gene Transfection. ACS applied materials & interfaces. 2020, 12(7):7905-7914. 5)P. Zhao#, W. J. Zhou#, Y. Zhang#, J. J. Li, Y. Zhao, L. H. Pan, Z. Y. Shen, W. Q. Chen, J. Hui. Aminooxyacetic acid attenuates post-infarct cardiac dysfunction by balancing macrophage polarization through modulating macrophage metabolism in mice. Journal of Cellular and Molecular Medicine. J Cell Mol Med. 24(4): 2593-2609. 6)J. Feng, Y. Wu, W. Chen, J. Li, X. Wang, Y. Chen, Y. Yu*, Z. Shen* and Y. Zhang*. Sustained Release of Bioactive IGF-1 from a Silk Fibroin Microsphere-Based Injectable Alginate Hydrogel for the Treatment of Myocardial Infarction.Journal of Materials Chemistry B, 2020, 8: 308-315. 7)Y. Wang, T. Wei, Y. Qu, Y. Zhou, Y. Zheng, C. Huang, Y. Zhang, Q. Yu* and H. Chen. Smart, Photothermally Activated, Antibacterial Surfaces with Thermally Triggered Bacteria-Releasing Properties. ACS Applied Materials & Interfaces 2020, 12(19): 21283–21291. 8)Y. C. Qu, Y. J. Zheng, L. Y. Yu, Y. Zhou, Y. R. Wang, Y. Zhang, Q. Yu and H. Chen. A Universal Platform for High-Efficiency Engineering Living Cells: Integration of Cell Capture, Intracellular Delivery of Biomolecules, and Cell Harvesting Functions. Advanced Functional Materials. 2020, 30(3): 1906362. 6. 2019年前发表文章1) H. Shen, G. Cui, Y. Li, W. Ye, Y. Sun, Z. Zhang, J. Li, G. Xu, X. Zeng, Y. Zhang, W. Zhang, Z. Huang, W. Chen and Z. Shen, Follistatin-like 1 protects mesenchymal stem cells from hypoxic damage and enhances their therapeutic efficacy in a mouse myocardial infarction model, Stem Cell Res Ther, 2019, 10(1): 17. 2) Y. Q. Chen, J. F. Zuo, W. Q. Chen, Z. Y. Yang, Y. Zhang, F. Hua, L. B. Shao, J. J. Li, Y. H. Chen, Y. S. Yu, Z. Y. Shen. The enhanced effect and underlying mechanisms of mesenchymal stem cells with IL-33 overexpression on myocardial infarction. Stem Cell Research & Therapy 2019, 10(1). 10:295 3) Y. Liu, C. Xu, Y. Gu, X. Shen, Y. Zhang, B. Li and L. Chen, Polydopamine-modified poly(l-lactic acid) nanofiber scaffolds immobilized with an osteogenic growth peptide for bone tissue regeneration, RSC Advances, 2019, 9(21): 11722-11736. 5) C. Tao#, Y. Zhang#, B. Li and L. Chen*, Hierarchical micro/submicrometer-scale structured scaffolds prepared via coaxial electrospinning for bone regeneration, Journal of Materials Chemistry B, 2017, 5(46): 9219-9228. 6) J. Sun#, Y. Zhang#, B. Li, Y. Gu* and L. Chen*, Controlled release of BMP-2 from a collagen-mimetic peptide-modified silk fibroin-nanohydroxyapatite scaffold for bone regeneration, Journal of Materials Chemistry B, 2017, 5(44): 8770-8779. 7) Q. Wang*, Y. Zhang*, B. Li and L. Chen*, Controlled dual delivery of low doses of BMP-2 and VEGF in a silk fibroin-nanohydroxyapatite scaffold for vascularized bone regeneration, Journal of Materials Chemistry B, 2017, 5(33): 6963-6972. 8) A. H. Tayeb, M. A. Hubbe, Y. Zhang and O. J. Rojas*, Effect of Lipoxygenase Oxidation on Surface Deposition of Unsaturated Fatty Acids, Langmuir, 2017, 33(18): 4559-4566. 9) Y. Xu#, W. Cui#, Y. Zhang#, P. Zhou, Y. Gu, X. Shen, B. Li and L. Chen*, Hierarchical Micro/Nanofibrous Bioscaffolds for Structural Tissue Regeneration, Adv Healthc Mater, 2017, 6(13). 1601457. 10) Y. Zhang* and O. J. Rojas*, Immunosensors for C-Reactive Protein Based on Ultrathin Films of Carboxylated Cellulose Nanofibrils, Biomacromolecules, 2017, 18(2): 526-534. 11) X. F. Shen#, Y. Zhang#, Y. Gu, Y. Xu, Y. Liu, B. Li and L. Chen*, Sequential and sustained release of SDF-1 and BMP-2 from silk fibroin-nanohydroxyapatite scaffold for the enhancement of bone regeneration, Biomaterials, 2016, 106: 205-216. 二、美国NSCU博士后期间(2012.1-2014.2,合作导师Orlando Rojas 教授)1) B.B. Langdon, R.B. Mirhossaini, J.N. Mabry, I. Sriram, A. Lajmi, Y. Zhang, et al., Single-molecule resolution of protein dynamics on polymeric membrane surfaces: the roles of spatial and population heterogeneity, ACS Applied Materials & Interfaces 2015, 7, 3607-3617. 2) H. Bai, J. Xu, Y. Zhang, X. Liu, O.J. Rojas, Dynamics of cyclodimerization and viscoelasticity of photo-crosslinkable PVA, J. Polym. Sci., B: Polym. Phys. 2015, 53, 345-355. 3) Y. Zhang*, R. G. Carbonell; O. J. Rojas* Bioactive cellulose nanofibrils for specific human IgG binding. Biomacromolecules 2013,14(12), 4161-4168. 4) Y. Zhang*, N. Islam; R. G. Carbonell; O. J. Rojas*, Specificity and renderability of short Peptide ligands supported on polymer layers for immunoglobulin g binding and detection. ACS Applied Materials & Interfaces 2013,5(16), 8030-8037. 5) Y. Zhang; T. Nypelö *; C. Salas, J. Arboleda; I. C. Hoeger*, O. J. Rojas*,Cellulose nanofibrils: from strong materials to bioactive surfaces. J. Renew. Mater. 2013, 1, 195-211. 6) Y. Zhang*; N. Islam, R. G. Carbonell.; O. J. Rojas*, Specific binding of immunoglobulin G with bioactive short peptides supported on antifouling copolymer layers for detection in quartz crystal microgravimetry and surface plasmon resonance. Anal. Chem. 2013, 85(2), 1106-1113. 三、硕士、博士期间(2005.9-2011.6,指导教师:陈红 教授)1) Zhang, Y.; Lv, B. E.; Lu, Z.; He, J. A.; Zhang, S.; Chen, H.*; Ma, H.* Predicting Au-S bond breakage from the swelling behavior of surface tethered polyelectrolytes. Soft Matter 2011, 7, 11496-11500. 2) Yu, Q.; Li, X.; Zhang, Y.; Yuan, L.; Zhao, T.; Chen, H.* The synergistic effects of stimuli-responsive polymers with nano-structured surfaces: wettability and protein adsorption. RSC Adv. 2011, 1, 262-269. 3) Zhang, Y.; He, J. A.; Zhu, Y.; Chen, H.; Ma, H.* Directly observed Au-S bond breakage due to swelling of the anchored polyelectrolyte. Chem. Commun. 2011, 47, 1190-1192. 4) Yu, Q.; Zhang, Y.; Wang, H.; Brash, J. L.; Chen, H.* Anti-fouling bioactive surfaces. Acta Biomater. 2011, 7, 1550-1557. 5) Yu, Q.; Chen, H.*; Zhang, Y.; Yuan, L.; Zhao, T.; Li, X.; Wang, H. pH-reversible, high-capacity binding of proteins on a substrate with nanostructure. Langmuir,2010, 26, 17812-17815. 6) Zhang, Y.; Yu, Q.; Huang, H.*; Zhou, F.; Wu, Z.; Yuan, L.; Li, D.; Chen, H.* A surface decorated with diblock copolymer for biomolecular conjugation. Soft Matter. 2010, 6, 2616–2618. 8) Yu, Q.; Zhang, Y.; Chen, H.*; Zhou, F.; Wu, Z.; Huang, H.; Brash, J. L. Protein adsorption and cell adhesion/detachment behavior on dual-responsive silicon surfaces modified with Poly(N-isopropylacrylamide)-block-polystyrene copolymer. Langmuir 2010, 26, 8582-8588. 9) Chen, H.*; Zhang, Y.; Li, D.; Hu, X.; Wang, L.; McClung, W. G.; Brash, J. L. Surfaces having dual fibrinolytic and protein resistant properties by immobilization of lysine on polyurethane through a PEG spacer. J. Biomed. Mater. Res., Part A 2009, 90, 940-946. 10) Wu, Z.; Chen, H.*; Liu, X.; Zhang, Y.; Li, D.; Huang, H. Protein adsorption on poly(N-vinylpyrrolidone)-modified silicon surfaces prepared by surface-initiated atom transfer radical polymerization. Langmuir 2009, 5, 2900-2906. 11) Chen, H.*; Wang, L.; Zhang, Y.; Li, D.; McClung, W. G.; Brook, M. A.; Sheardown, H.; Brash, J. L. Fibrinolytic poly(dimethyl siloxane) surfaces. Macromol. Biosci. 2008, 8, 863-870. 12) Chen, H.*; Hu, X.; Zhang, Y.; Li, D.; Wu, Z.; Zhang, T. Effect of chain density and conformation on protein adsorption at PEG-grafted polyurethane surfaces. Colloids Surf., B 2008, 61, 237-243. 13) 张燕霞; 于谦; 武照强; 周峰; 李鑫; 陈红*能够促进细胞黏附的生物活性表面的制备. 高分子学报,2011, (6), 622-627. 14) 张燕霞; 于谦; 周峰; 徐亚骏; 陈红*嵌段共聚物改性表面对蛋白质吸附和细胞黏附的调控. 科学通报,2010, 55, 2808-2814. 15) 于谦; 张燕霞; 徐亚骏; 陈红接枝层厚度对聚(N-异丙基丙烯酰胺)改性表面与蛋白质相互作用的影响. 材料导报,2010, 24, 25-28. 16) 于谦; 张燕霞; 李鑫; 徐亚骏; 陈红*,聚(N-异丙基丙烯酰胺)改性表面与血浆蛋白质的相互作用. 高分子学报,2011, (5), 537-542. 17) 李鑫; 于谦; 张燕霞; 武照强; 陈红*,pH响应性表面对蛋白质吸附的调控. 高分子学报,2011, (8), 812-816.(英文摘要) 18) 于谦; 张燕霞; 周峰; 李鑫; 陈红*,聚(N-异丙基丙烯酰胺)-b-聚苯乙烯改性玻璃表面对细胞黏附/脱附的调控. 材料导报,2011, 25, 23-26. 19) 胡小洋; 张燕霞; 张弢; 于谦; 陈红*,以PEG为间隔基固定赖氨酸制备血液相容的聚氨酯材料. 高等学校化学学报,2009, 30, 613-617. 20) 胡小洋; 陈红*; 张燕霞; 王艺峰; 吴仲岿聚乙二醇及其衍生物改性生物医用材料表面的血液相容性. 高分子材料科学与工程,2007, 23, 127-131. 四、专利1) 陈红; 张燕霞; 于谦一种高密度固定生物功能分子的材料的制备方法CN 101810888 A 2) 张燕霞,于谦,吴永,沈振亚,周霄楠;一种细菌纤维素膜的脱水方法及人造血管及其制备方法;201910265404.6 荣誉奖励
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