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个人信息
个人简介
2006.9-2010.6 南京大学 物理学院 凝聚态物理 本科 2010.9-2015.6 南京大学 物理学院 软物质物理 硕博连读 2015.8-2020.9 18新利体育 软凝聚态物理及交叉研究中心 副教授 2020.10-至今 18新利体育 软凝聚态物理及交叉研究中心 特聘教授 国家优秀青年基金获得者,主要从事软凝聚态物理、计算生物物理、统计物理的交叉领域研究,包括纳米载体与细胞膜、生物大分子等界面相互作用和生物大分子自组装、相分离等方面的理论模拟研究。以第一作者和通讯作者身份(含共同)在Nature Communications(2篇), Science Advances, Proc. Natl. Acad. Sci. U.S.A.,J. Am. Chem. Soc.(4篇), ACS Central Science, Angew. Chem. Int. Ed.(2篇), ACS Nano(4篇)等权威SCI期刊发表论文60余篇,包括12篇封面/封底论文。所有论文累计引用超2800次(H-index 27),单篇最高他引近300次,11篇论文引用超100次;授权发明专利一项(ZL 2021 1 1333136.0)。曾承担国家自然科学基金面上项目、青年基金等。2016年入选苏州市高等院校、科研院所紧缺高层次人才,2017年入选18新利体育 首批优秀青年学者,2019年获江苏省科学技术二等奖(排名第2),2021年入选国际组织Vebleo Fellow,2022年入选江苏省333高层次人才培养工程(第三层次)。 Google Scholar: https://scholar.google.com/citations?user=mI12lawAAAAJ&hl=en ResearchGate: https://www.researchgate.net/profile/Hong-Ming-Ding
1. ACS Nano, 18, 6463-6476 (2024) 2. ACS Nano, 18, 2162–2183 (2024) 3. Proc. Natl. Acad. Sci. U.S.A.,119, e2211538119 (2022) 4. Science Advances, 8, eabo7885 (2022) 5. Angew. Chem. Int. Ed., 59, 9617-9623 (2020) 6. J. Am. Chem. Soc., 142, 4800-4806 (2020) [Back Cover] 7. J. Am. Chem. Soc., 141, 18910-18915 (2019) 9. J. Am. Chem. Soc., 141, 16014-16023 (2019) 9. Nature Communications, 10, 4520 (2019) 10. J. Am. Chem. Soc., 141, 583-591 (2019) [Front Cover] 研究领域
1.纳米粒子与细胞膜界面作用的物理机理; 2.蛋白冠对纳米粒子生物学行为的影响; 3.纳米粒子、大分子自组装或相分离机理研究。 基本信息
职称:教授 院部/部门:物理科学与技术学院 学历: 学位: 毕业学校: 毕业专业: 联系方式
通讯地址: 邮政编码: 电子邮箱:dinghm@suda.edu.cn 联系电话: 传真号码: 办公地点:物理科技楼247室 18新利备用网站
近些年来,纳米材料已经在很多科学技术领域得到了广泛的应用。作为其中发展最为迅猛的崭新领域之一,纳米医学目前得到了大家越来越多的重视。与传统材料相比,纳米材料由于其独特的物理化学性质,使其在生物传感,细胞成像,药物输运等方面有着显著的优势。理解纳米材料与生物体,尤其是与细胞和生物大分子(蛋白、DNA/RNA等)间的相互作用对在生物医药领域更好地利用纳米材料(例如提高输运效率同时减少毒副作用)有着非常重要的科学意义。
科研团队
与马余强院士联合团队:
2. 黄舒伟(2020级硕士,南京大学联合培养),以第二作者在Nanoscale Adv., CPB各发表1篇论文,目前在苏州某中学当老师; 3.朱雨欣(2020级硕士),以第一作者在JPCB发表论文1篇,曾获优秀班干部,目前在苏州某中学当老师; 4.倪崧荻(2019级博士),以第一作者在Langmuir发表论文2篇,其中一篇被选为杂志副封面,目前在上海某研究所工作; 5. 盛艳静(2019级硕士),以第一作者在分子模拟领域权威杂志J. Chem. Inf. Model.发表论文1篇,并选为杂志副封面,目前在苏州某中学当老师; 6. 卢翔(2017级博士,南京大学联合培养) 以第一作者身份在权威杂志Nature Communications发表论文一篇,获得国家奖学金,目前在无锡医药企业工作; 7. 夏强胜 (2015级在职博士,安庆师范大学副教授) 以第一作者身份在Nanoscale发表两篇论文(其中一篇选为封底),J. Phys. D发表一篇论文; 8. 余幼胜(2015级博士,南京大学联合培养) 以第一作者身份在Phys. Chem. Chem. Phys.(封面论文),RSC Adv.发表论文各2篇,以第二作者身份在Nanoscale、Inorganic Chemistry发表论文各一篇,目前在东华理工大学工作; 10. 黄路易 (2016级硕士,南京大学联合培养) 以第一作者身份在Nanoscale(封面论文)发表论文一篇,获得国家奖学金,目前在网易工作; 论文
Cover Gallery: 发表论文(*通讯作者,#并列一作): 70. Meng-Qiu Li, Chen Chen, Yu-Qiang Ma and Hong-Ming Ding*, Effect of terahertz waves on the aggregation behavior of neurotransmitters, Phys. Chem. Chem. Phys., 26, 13751-13761 (2024); 69. Yuan-Qiang Chen#, Meng-Die Xue#, Jia-Li Li, Da Huo*, Hong-Ming Ding*, and Yuqiang Ma*, Uncovering the Importance of Ligand Mobility on Cellular Uptake of Nanoparticles: Insights from Experimental, Computational, and Theoretical Investigations, ACS Nano 18, 6463-6476 (2024); 68. Hui-Yue Zhao#, Yuan-Qiang Chen#, Xing-Yu Luo#, Ming-Jie Cai, Jia-Yi Li, Xin-Yu Lin, Hao Zhang*, Hong-Ming Ding*, Guang-Liang Jiang*, and Yong Hu*, Ligand Phase Separation-Promoted, “Squeezing-Out” Mode Explaining the Mechanism and Implications of Neutral Nanoparticles That Escaped from Lysosomes, ACS Nano 18, 2162–2183 (2024); 67. Zeng-Shuai Yan, Yu-Qiang Ma*, Hong-Ming Ding*, Unveiling the multicomponent phase separation through molecular dynamics simulation and graph theory, J. Chem. Phys. 160, 064907 (2024); 66. Min Wang, Song-Di Ni, Yue-Wen Yin*, Yu-Qiang Ma, and Hong-Ming Ding*, Molecular Modeling of the Fluorination Effect on the Penetration of Nanoparticles across Lipid Bilayers, Langmuir 40, 1295–1304 (2024); 65. Yao Xu, Zeng-Shuai Yan, Yu-Qiang Ma*, Hong-Ming Ding*, Topology- and size-dependent binding of DNA nanostructures to the DNase I, International Journal of Biological Macromolecules 257, 128703 (2024); 64. You-Sheng Yu, Rong-Ri Tan*, Hong-Ming Ding*, Effect of surface functionalization on DNA sequencing using MXene-based nanopores, RSC Adv. 14, 405-412 (2024); 63. Yao Xu, Shu-Wei Huang, Hong-Ming Ding* and Yu-Qiang Ma, Molecular dynamics simulations on the interactions between nucleic acids and a phospholipid bilayer, Chinese Physics B 33, 028701(2024)[Highlighted]; 62. Qi Niu#, Dr. Yun Shu#, Yuanqiang Chen#, Zhi Huang, Zhixian Yao, Xiaofeng Chen, Fanghe Lin, Jianzhou Feng, Chen Huang, Dr. Hua Wang, Hongming Ding, Chaoyong Yang, Lingling Wu*, A Fluid Multivalent Magnetic Interface for High-Performance Isolation and Proteomic Profiling of Tumor-Derived Extracellular Vesicles, Angew. Chem. Int. Ed. 62, e202215337 (2023); 61. Xiao-Lei Li, Zeng-Shuai Yan, Yu-qiang Ma*, and Hong-ming Ding*, Effect of maleylation and denaturation of human serum albumin on its interaction with scavenger receptors, Proteins-Structure Function And Bioinformatics 91, 1140-1151 (2023); 60. You-Sheng Yu, Qiang Ren, Rong-Ri Tan*, and Hong-Ming Ding*, Exploring the non-monotonic DNA capture behavior in a charged graphene nanopore, Phys. Chem. Chem. Phys. 25, 28034-28042 (2023); 59. Chen Chen, Zeng-Shuai Yan, Yu-qiang Ma*, and Hong-ming Ding*, Effect of Terahertz Waves on the Structure of the Aβ42 Monomer, Dimer, and Protofibril: Insights from Molecular Dynamics Simulations, ACS Chem. Neurosci. 14, 4128–4138 (2023); 58. Zeng-Shuai Yan, Xiao-Lei Li, Yu-Qiang Ma*, and Hong-Ming Ding*, Effect of the Graphene Nanosheet on Functions of the Spike Protein in Open and Closed States: Comparison between SARS-CoV-2 Wild Type and the Omicron Variant, Langmuir 38, 13972-13982 (2022); 57. Junxia Wang , Liang Li , Yingkun Zhang, Kaifeng Zhao, Xiaofeng Chen, Haicong Shen, Yuanqiang Chen , Jia Song, Yuqiang Ma, Chaoyong Yang, Hongming Ding*, and Zhi Zhu*,Synergetic collision and space separation in microfluidic chip for efficient affinity-discriminated molecular selection, Proc. Natl. Acad. Sci. U.S.A. 119, e2211538119 (2022); 56. Chun-Lai Ren*, Yue Shan, Peifei Zhang, Hong-Ming Ding*, Yu-Qiang Ma*, Uncovering the molecular mechanism for dual effect of ATP on phase separation in FUS solution, Science Advances 8, eabo7885 (2022); 55. Zeng-Shuai Yan, Yao Xu, Hong-Ming Ding* and Yu-Qiang Ma*, Molecular Insights into Striking Antibody Evasion of SARS-CoV-2 Omicron Variant, Chin. Phys. Lett. 39, 108701 (2022); 54. Yu-Xin Zhu, Yan-Jing Sheng, Yu-Qiang Ma, Hong-Ming Ding*, Assessing the Performance of Screening MM/PBSA in Protein–Ligand Interactions, J. Phys. Chem. B 126, 1700–1708 (2022); 53. Yuan-qiang Chen, Yan-jing Sheng, Yu-qiang Ma, Hong-ming Ding*, Efficient calculation of protein–ligand binding free energy using GFN methods: the power of the cluster model, Phys. Chem. Chem. Phys. 24, 14339-14347 (2022); 52. Yao Xu, Shu-wei Huang, Yu-qiang Ma*, Hong-ming Ding*, Loading of DOX into a tetrahedral DNA nanostructure: the corner does matter, Nanoscale Adv. 4, 754-760 (2022); 51. Yuan-Qiang Chen, Yan-Jing Sheng, Hong-Ming Ding* and Yu-Qiang Ma*, Evaluation on the performance of MM/PBSA in nucleic acid-protein systems, Chinese Physics B 31, 048701 (2022); 50. Song-Di Ni, Ya-Li Chen, Yuan-Qiang Chen, Kun Zhou*, and Hong-Ming Ding*, Molecular Simulation Studies on the Interactions of Bilirubin at Different States with a Lipid Bilayer, Langmuir, 37, 11707-11715 (2021); 49. Xiaofeng Chen, Hongming Ding, Dongdong Zhang, Kaifeng Zhao, Jiafeng Gao, Bingqian Lin, Chen Huang, Yanling Song, Gang Zhao*, Yuqiang Ma,* Lingling Wu*, Chaoyong Yang*, Reversible Immunoaffinity Interface Enables Dynamic Manipulation of Trapping Force for Accumulated Capture and Efficient Release of Circulating Rare Cells, Adv. Sci., 8, 2102070 (2021); 48. Gui-Fei Huo, Qian Tu, Yi-Xiong Hu, Bo Jiang, Qi-Feng Zhou, Yanfei Niu, Xiaoli Zhao, Hong-Ming Ding*, Jin Wen*, Guang-Qiang Yin, Xueliang Shi, Lin Xu*, Amplified circularly polarized luminescence promoted by hierarchical self-assembly involving Pt···Pt interactions, Sci. China Mater., Doi:10.1007/s40843-021-1750-9 (2021); 47. Yue-wen Yin, Yan-jing Sheng, Min Wang, Yu-qiang Ma*, Hong-ming Ding*, Interaction of serum proteins with SARS-CoV-2 RBD, Nanoscale, 13, 12865-12873 (2021);[Front Cover] 46. Yan-jing Sheng, Yue-wen Yin, Yu-qiang Ma, and Hong-ming Ding*, Improving the Performance of MM/PBSA in Protein–Protein Interactions via the Screening Electrostatic Energy, J. Chem. Inf. Model. 61, 2454–2462 (2021);[Back Cover] 45. Hong-ming Ding*, Yue-wen Yin, Song-di Ni, Yan-jing Sheng, and Yu-qiang Ma*, Accurate Evaluation on the Interactions of SARS-CoV-2 with Its Receptor ACE2 and Antibodies CR3022/CB6, Chin. Phys. Lett. (Express Letter), 38 018701 (2021); 44. Shu-Ting Jiang, Wei Zheng, Guang Yang, Yu Zhu, Li-Jun Chen, Qi-Feng Zhou, Yu-Xuan Wang, Zhen Li, Guang-Qiang Yin, Xiaopeng Li, Hong-Ming Ding, Guosong Chen*, Hai-Bo Yang*, Construction of Metallacycle-Linked Heteroarm Star Polymers via Orthogonal Post-Assembly Polymerization and Their Intriguing Self-Assembly into Large-Area and Regular Nanocubes, Chin. J. Chem., 38, 1285-1291 (2020); 43. Ya-Tong Zhao, Shuai Yan, Bin Huang, Liuyan Yang, Hong-ming Ding*, Ping Wang, and Ai-Jun Miao*, Unbound Natural Organic Matter Competes with Nanoparticles for Internalization Receptors During Cell Uptake, Environ. Sci. Technol., 54, 15215–15224 (2020); 42. Yu-sheng Yu, Rong-ri Tan*, and Hong-ming Ding*, Controlling ion transport in a C2N-based nanochannel with tunable interlayer spacing, Phys. Chem. Chem. Phys., 22, 16855-16861 (2020); 41. Rongying Liu, Zdravko Kochovski, Long Li, Yue-wen Yin, Jing Yang, Guang Yang, Guoqing Tao, Anqiu Xu, Ensong Zhang, Hong-ming Ding*, Yan Lu*, Guosong Chen*, Ming Jiang, Fabrication of Pascal-triangle Lattice of Proteins by Inducing Ligand Strategy, Angew. Chem. Int. Ed., 59, 9617-9623 (2020); 40. Qiang-Sheng Xia#, Tao Zhu#, Zhongying Jiang, Hong-ming Ding* and Yu-qiang Ma*, Enhancing the targeting ability of nanoparticles via protected copolymers, Nanoscale, 12, 7804-7813 (2020); 39. Lingling Wu#, Hongming Ding#, Xin Qu, Xianai Shi, Jianmin Yang, Mengjiao Huang, Jialu Zhang, Huimin Zhang, Jia Song, Lin Zhu, Yanling Song,* Yuqiang Ma,* Chaoyong Yang*, Fluidic Multivalent Membrane Nanointerface Enables Synergetic Enrichment of Circulating Tumor Cells with High Efficiency and Viability, J. Am. Chem. Soc., 142, 4800-4806 (2020); 38. Guoqing Tao, Tan Ji, Ning Wang, Guang Yang, Xiaolai Lei, Wei Zheng, Rongying Liu, Xuyang Xu, Ling Yang, Guang-Qiang Yin, Xiaojuan Liao, Xiaopeng Li, Hong-ming Ding, Xiaoming Ding, Jinfu Xu*, Hai-Bo Yang*, Guosong Chen*, Self-Assembled Saccharide-Functionalized Amphiphilic Metallacycles as Biofilms Inhibitor via “Sweet Talking”, ACS Macro Lett. 9, 61-69 (2020); 37. Min Li#, Hong-ming Ding#, Meihua Lin#, Fangfei Yin, Lu Song, Xiuhai Mao, Fan Li, Zhilei Ge, Lihua Wang, Xiaolei Zuo*, Yuqiang Ma*, Chunhai Fan, DNA framework-programmed cell capture via topology-engineered receptor-ligand interactions, J. Am. Chem. Soc., 141, 18910-18915 (2019); 36. Guang Yang, Wei Zheng, Guoqing Tao, Libin Wu, Qi-Feng Zhou, Zdravko Kochovski, Tan Ji, Huaijun Chen, Xiaopeng Li, Yan Lu, Hong-ming Ding*, Hai-Bo Yang*, Guosong Chen*, Ming Jiang, Diversiform and Transformable Glyco-Nanostructures Constructed from Amphiphilic Supramolecular Metallocarbohydrates through Hierarchical Self-Assembly: The Balance between Metallacycles and Saccharides, ACS Nano, 13, 13474-13485 (2019); 35. Xiang Lu, Peipei Xu, Hong-Ming Ding*, You-Sheng Yu, Da Huo*, Yu-Qiang Ma*, Tailoring the component of protein corona via simple chemistry, Nat. Commun. 10, 4520 (2019); 34. Gui-Fei Huo, Xueliang Shi*, Qian Tu, Yi-Xiong Hu, Gui-Yuan Wu, Guang-Qiang Yin, Xiaopeng Li, Lin Xu, Hong-Ming Ding*, Hai-Bo Yang*, Radical-Induced Hierarchical Self-Assembly Involving Supramolecular Coordination Complexes in Both Solution and Solid States, J. Am. Chem. Soc. 141, 16014-16023 (2019); 33. Song-di Ni, Yue-wen Yin, Xiao-lei Li, Hong-ming Ding*, Yu-qiang Ma, Controlling the Interaction of Nanoparticles with Cell Membranes by the Polymeric Tether, Langmuir 35, 12851-12857 (2019);[Inside Cover] 32. Zhen Li, Yufei Zhang, Libin Wu, Wei Yu, Thomas R. Wilks, Andrew P. Dove, Hong-ming Ding*, Rachel K. O’Reilly*, Guosong Chen*, and Ming Jiang, Glyco-Platelets with Controlled Morphologies via Crystallization-Driven Self-Assembly and Their Shape-Dependent Interplay with Macrophages, ACS Macro Lett., 8, 596-602 (2019); 31. Wei Zheng, Wei Wang, Shu-ting Jiang, Guang Yang, Zhen Li, Xu-qing Wang, Guang-qiang Yin, Ying Zhang, Hongwei Tang, Xiaopeng Li, Hong-ming Ding*, Guosong Chen*, Hai-Bo Yang*, Supramolecular Transformation of Metallacycle-Linked Star Polymers Driven by Simple Phosphine Ligand-Exchange Reaction, J. Am. Chem. Soc., 141, 583-591 (2019);[Front Cover] 30. Lu-yi Huang, You-sheng Yu, Xiang Lu, Hong-ming Ding*and Yu-qiang Ma*, Designing nanoparticle-containing polymeric substrate for detecting cancer cells by computer simulations, Nanoscale, 11, 2170-2178 (2019);[Back Cover] 25. Guang Yang, Rongting Hu, Hong-ming Ding*, Z. Kochovski, Shilin Mei, Yan Lu, Yu-qiang Ma, Guosong Chen* and Ming Jiang, CO2-switchable response of protein microtubule: behaviour and mechanism, Mater. Chem. Front., 2, 1642-1646 (2018) ; 荣誉奖励
开授课程
1. 计算物理 (大三) 招生信息
一级学科为物理学、化学、计算机科学、材料科学等学科方向的本科生,可与南京大学联合培养。 联系方式: 18新利体育 本部物理科技楼247室 联系电话:0512-69155695 dinghm@suda.edu.cn |