徐鹏，特聘教授，博士生导师
18新利体育 苏州医学院唐仲英医学研究院血液学研究中心
18新利体育 放射医学与辐射防护国家重点实验室
苏州工业园区仁爱路199号703号楼3625室；邮编：215123
邮箱：pengxu@suda.edu.cn
教育经历：
2006年~2010年 中南大学生物技术专业理学学士
2010年~2015年 北京协和医学院生物化学与分子生物学专业理学博士，导师刘德培院士2015年~2020年 美国圣裘德儿童研究医院血液学博士后，合作导师Mitchell J. Weiss教授
工作经历：
2020年~至今 18新利体育 苏州医学院唐仲英血液学研究中心
18新利体育 放射医学与辐射防护国家重点实验室
研究方向：
实验室长期规划：面向国家重大临床需求，以重大科学问题为导向，建立一个以研究造血发育调控与恶性血液疾病为核心的基础和临床相结合的研究室。目前涵盖三个前沿子方向：1.以新型基因编辑技术和高通量遗传筛选技术为手段，结合转录组学，蛋白组学和表观遗传组学等多重组学研究造血发育调控与恶性血液肿瘤的全新分子调控机制。 2.利用碱基基因编辑技术解析地中海贫血的分子机制和开发新型基因治疗策略。3.利用高通量遗传筛选技术解析泛素连接酶、表观遗传修饰酶和激酶等酶类分子在放射生物效应的作用与机制。
承担项目：
1.国家重点研发计划重点专项子课题（2022YFC2502702）；2022-2025；学术骨干参与
2.江苏省江苏特聘教授，2022
3.国家自然科学基金面上项目（#82170119）；2022-2025；主持
4.江苏省青年基金项目（BK20210714）；2020-2024；主持
5.苏州市姑苏青年领军人才创新类项目（ZXL2022443）；2021-2024；主持
6.苏州市科协青年科技人才托举工程项目；2021-2022，主持
7.江苏省“双创”博士（JSSCBS20210692)
发表论文：
(# equal contribution * corresponding author)
1.Peng Xu; Daniel C. Scott; Beisi Xu; Yu Yao; Ruopeng Feng; Li Cheng; Kalin Mayberry; Yong-Dong Wang; Wenjian Bi; Lance E. Palmer; Moeko T. King; Hong Wang; Yuxin Li; Yiping Fan; Arno F. Alpi; Chunliang Li; Junmin Peng; James Papizan; Shondra M. Pruett-Miller; Ria Spallek; Florian Bassermann; Yong Cheng; Brenda A. Schulman; Mitchell J. Weiss*; FBXO11-mediated proteolysis of BAHD1 relieves PRC2-dependent transcriptional repression in erythropoiesis, Blood, 2021, 137(2): 155-167. (Highlighted Article)
2.Peng Xu#; Lance E. Palmer#; Christophe Lechauve; Guowei Zhao; Yu Yao; Jing Luan; Anastasios Vourekas; Haiyan Tan; Junmin Peng; John D. Schuetz; Zissimos Mourelatos; Gang Wu; Mitchell J. Weiss*; Vikram R. Paralkar*; Regulation of gene expression by miR-144/451 during mouse erythropoiesis, Blood, 2019, 133(23): 2518-2528.
3.Ozge Karayel#; Peng Xu#; Isabell Bludau; Senthil Velan Bhoopalan; Yu Yao; Ana Rita Freitas Colaco; Alberto Santos; Brenda A Schulman*; Arno F Alpi*; Mitchell J Weiss*; Matthias Mann*; Integrative proteomics reveals principles of dynamic phosphosignaling networks in human erythropoiesis, Molecular Systems Biology, 2020, 16(e9813).
4.Peng Xu#; Ting-ting Wang#; Xiu-zhen Liu#; Nan-Yu Wang; Li-hong Sun; Zhu-qin Zhang; Hou-zao Chen; Xiang Lv; Yue Huang; De-Pei Liu*; Sirt6 regulates efficiency of mouse somatic reprogramming and maintenance of pluripotency, Stem Cell Research & Therapy, 2019, 10(9).
5.Mengli Zhang #; Mei Meng #; Yuxi Liu; Jindan; Zhe Zhao; Yingnan Qiao; Yanxing Hu; Wei Lu; Zhou Zhou;Peng Xu*; Quansheng Zhou*; Triptonide effectively inhibits triple-negative breast cancer metastasis through concurrent degradation of Twist1 and Notch1 oncoproteins, Breast Cancer Research, 2021,23:116.
6.Dawafuti Sherpa#, Judith Müller#, Özge Karayel#, Peng Xu#, Yu Yao, Jakub Chrustowicz, Karthik V. Gottemukkala, Christine Baumann, Annette Gross, Oliver Czarnezki, Wei Zhang, Jun Gu, Johan Nilvebrant, Sachdev S. Sidhu, Peter J. Murray, Matthias Mann, Mitchell J. Weiss, Brenda A. Schulman, Arno F. Alpi*; Modular UBE2H-CTLH E2-E3 complexes regulate erythroid maturation, eLife, 2022, 11:e77937.
7.Ruopeng Feng, Thiyagaraj Mayuranathan, Peng Huang , Phillip A Doerfler, Yichao Li, Yu Yao, Jingjing Zhang, Lance E Palmer, Kalin Mayberry, Georgios E Christakopoulos, Peng Xu, Chunliang Li, Yong Cheng, Gerd A Blobel, M Celeste Simon, Mitchell J Weiss*; Activation of γ-globin expression by hypoxia-inducible factor 1α, Nature, 2022, 610(7933):783-790.
8.Li Cheng#; Yichao Li#; Qian Qi; Peng Xu; Ruopeng Feng; Lance Palmer; Jingjing Chen; Ruiqiong Wu; Tiffany Yee; Jingjing Zhang; Yu Yao; Akshay Sharma; Ross C. Hardison; Mitchell J. Weiss*; Yong Cheng*; Single-nucleotide–level mapping of DNA regulatory elements that control fetal hemoglobin expression, Nature Genetics, 2021,53(6):869-880.
9.Xiuqin Bao#; Xinhua Zhang#; Liren Wang; Zhongju Wang; Jin Huang; Qianqian Zhang; Yuhua Ye; Yongqiong Liu; Diyu Chen; Yangjin Zuo; Qifa Liu; Peng Xu; Binbin Huang; Jianpei Fang; Jinquan Lao; Xiaoqin Feng; Yafeng Li; Ryo Kurita; Yukio Nakamura; Weiwei Yu; Cunxiang Ju; Chunbo Huang; Narla Mohandas; Dali Li; Cunyou Zhao*; Xiangmin Xu*; Epigenetic inactivation of ERF reactivates γ-globin expression in β-thalassemia, The American Journal of Human Genetics, 2021, 108(4): 709-721.
10.Xiaoqiang Tang#; Xiao-Feng Chen#; Xin Sun#; Peng Xu; Xiang Zhao; Ying Tong; Xiao-Man Wang; Ke Yang; Yu-Tong Zhu; De-Long Hao; Zhu-Qin Zhang; De-Pei Liu*; Hou-Zao Chen*; Short-Chain Enoyl-CoA Hydratase Mediates Histone Crotonylation and Contributes to Cardiac Homeostasis, Circulation, 2021, 143(10): 1066-1069.
11.Qian Qi#; Li Cheng#; Xing Tang; Yanghua He; Yichao Li; Tiffany Yee; Dewan Shrestha; Ruopeng Feng; Peng Xu; Xin Zhou; Shondra Pruett-Miller; Ross C. Hardison; Mitchell J. Weiss; Yong Cheng*; Dynamic CTCF binding directly mediates interactions among cis-regulatory elements essential for hematopoiesis, Blood, 2021, 137(10): 1327-1339.
12.Yao Yao#; Fei Ye#; Kailong Li; Peng Xu; Wenjie Tan; Quansheng Feng; Shuquan Rao*; Genome and epigenome editing identify CCR9 and SLC6A20 as target genes at the 3p21.31 locus associated with severe COVID-19. Signal Transduct Target Ther.,2021,6(1):85.
13.Judith Hyle#; Yang Zhang#; Shaela Wright; Beisi Xu; Ying Shao; John Easton; Liqing Tian; Ruopeng Feng; Peng Xu; Chunliang Li*; Acute depletion of CTCF directly affects MYC regulation through loss of enhancer-promoter looping, Nucleic Acids Research, 2019, 47(13): 6699-6713.
14.Xiao Fang#; Feiyang Shen#; Christophe Lechauve; Peng Xu; Guowei Zhao; Jacobi Itkow; Fan Wu; Yaying Hou; Xiaohui Wu; Lingling Yu; Huiqing Xiu; Mengli Wang; Ruiling Zhang; Fangfang Wang; Yanqing Zhang; Daxin Wang; Mitchell J. Weiss; Duonan Yu*; miR-144/451 represses the LKB1/AMPK/mTOR pathway to promote red cell precursor survival during recovery from acute anemia, Haematologica, 2018, 103(3): 406-416.
15.Wen-Li Mu#; Ya-Jun Wang#; Peng Xu#; De-Long Hao; Xiu-Zhen Liu; Ting-Ting Wang; Feng Chen; Hou-Zao Chen; Xiang Lv; De-Pei Liu*; Sox2 Deacetylation by Sirt1 Is Involved in Mouse Somatic Reprogramming, Stem Cells, 2015, 33(7): 2135-2147.
16.Peng Xu#; Ying Tong#; Xiu-zhen Liu; Ting-ting Wang; Li Cheng; Bo-yu Wang; Xiang Lv; Yue Huang; De-pei Liu*; Both TALENs and CRISPR/Cas9 directly target the HBB IVS2–654 (C > T) mutation in β-thalassemia derived iPSCs, Scientific Reports, 2015, 5(12065).
团队成员：
科研助理：杨雪
在读研究生：
张梦利（2021级博士研究生）、张建祥（2022级博士研究生）、辛晔（2020级硕士研究生）、徐进超（2021级硕士研究生）、金英才（2021级硕士研究生）、陈新凤（2022级硕士研究生）
邵聪文（2019级博士研究生，南方医科大学联合培养）、刘清（2019级硕博连读研究生，南方医科大学联合培养）
实验室文化：“严谨，求实，快乐，平等”
招生专业：基础医学-医学细胞与分子生物学
诚邀有志有科研激情、扎实阳光的青年“后浪”加盟，为18新利体育 放射医学与辐射防护国家重点实验室的发展贡献力量！实验室网站: https://www.x-mol.com/groups/pengxu_lab