季兴跃

发布者：管理员发布时间：2018-12-13浏览次数：8705

季兴跃, Ph.D.

教育背景


◇本科& 硕士(9/2002 – 7/2008)

北京科技大学应用学院，应用化学/分析化学

导师：杨运旭教授

◇博士 (9/2008 – 7/2011)

中国医学科学院北京协和医学院医药生物技术研究所, 微生物与生化药学

导师：李卓荣研究员

  

工作经历

12/2014-至今：Research Scientist, 佐治亚州立大学化学系，导师：王炳和教授

12/2013-12/2014: 博士后, 佐治亚州立大学,化学系, 导师：王炳和教授

9/2011-12/2013: 助理研究员, 协和医学院医药生物技术研究所

  

荣誉及奖励

入选2018年Marquis Who’s Who in America

发表文章

1.Yueqing Zheng#, Xingyue Ji#,Bingchen Yu, Kaili Ji, Gallo, D.; Csizmadia, E.; Mengyuan Zhu, Roy Choudhury, M.; De La Cruz, L.; Chittavong, V.; Zhixiang Pan, Zhengnan Yuan, Otterbein, L. E.; Binghe Wang*. Enrichment-triggered Prodrug Activation Demonstrated through Mitochondria-targeted Delivery of Doxorubicin and Carbon Monoxide. Nat. Chem. 2018, 10, 787-794. (# 并列一作)

2.Xingyue Ji and Binghe Wang. Strategies toward Organic Carbon Monoxide Prodrugs. Acc. Chem. Res. 2018, 51 (6), 1377–1385.

3.Xingyue Ji, Cheng Zhou, Kaili Ji, Robert E. Aghoghovbia, Zhixiang Pan, Vayou Chittavong, Bowen Ke, Binghe Wang. Click and Release: A Chemical Strategy toward Developing Gasotransmitter Prodrugs by Using an Intramolecular Diels–Alder Reaction. Angew. Chem. Int. Ed. 2016, 55(51):15846-15851. (X-Mol 亮点报道).

4.Xingyue Ji, Eman M. El-labbad, Kaili Ji, Deena S. Lasheen, Rabah A.T. Serya, Khaled A. Abouzid, and Binghe Wang. Click and Release: SO2 Prodrugs with Tunable Release Rates. Org. Lett. 2017, 19 (4): 818–821. (X-Mol 亮点报道).

5.Zhixiang Pan, Jun Zhang, Kaili Ji, Vayou Chittavong, Xingyue Ji*, and Binghe Wang*.Organic CO Prodrugs Activated by Endogenous ROS. Org. Lett. 2018, 20, 8-11. (X-Mol 亮点报道).

6.Ladie Kimberly C. De La Cruz, Stéphane L. Benoit, Zhixiang Pan, Bingchen Yu, Robert J. Maier, Xingyue Ji*and Binghe Wang*. Click, release, and fluoresce: a chemical strategy for a cascade prodrug system for co-delivery of carbon monoxide, a drug payload and a fluorescent reporter. Org. Lett. 2018, 20 (4), pp 897–900. (Highlighted in 13 international press: https://acs.altmetric.com/details/32433850/news).

7.Xingyue Ji, Jinhua Chen, Guanghui Zheng, Menghao Huang, Lei Zhang, Hong Yi, Jie Jin, Jiandong Jiang, Zonggen Peng, and Zhuorong Li. Design and Synthesis of Cajanine Analogues against Hepatitis C Virus through Down-Regulating Host Chondroitin Sulfate N-Acetylgalactosaminyltransferase 1. J. Med. Chem., 2016, 59 (22), 10268–10284. (BioCentury Innovations 及X-Mol 亮点报道).

8.Xingyue Ji, Ladie Kimberly C. De La Cruz, Zhixiang Pan, Vayou Chittavong and Binghe Wang*. pH-Sensitive metal-free carbon monoxide prodrugs with tunable and predictable release rates. Chem. Commun. 2017, 53, 9628-9631.

9.Xingyue Ji, Kaili Ji, Vayou Chittavong, Bingchen Yu, Zhixiang Pan and Binghe Wang.An esterase-activated click and release approach to metal-free CO-prodrugs. Chem. Commun., 2017, 53, 8296-8299.

10.Wenyi Wang, Xingyue Ji,* Zhenming Du and Binghe Wang*. Sulfur dioxide prodrugs: triggered release of SO2 via a click reaction. Chem. Commun., 2017, 53(8): 1370-1373 (内封面故事).

11.Zhixiang Pan, Vayou Chittavong, Wei Li, Jun Zhang, Kaili Ji, Mengyuan Zhu, Xingyue Ji,* and Binghe Wang*. Organic CO-prodrugs: Structure CO-release rate relationship Studies. Chem. Eur. J. 2017, 23, 9838-9845.

12.Xingyue Ji, Kaili Ji, Vayou Chittavong, Robert E. Aghoghovbia, Mengyuan Zhu, and Binghe Wang.Click and Fluoresce: A Bioorthogonally Activated Smart Probe for Wash-Free Fluorescent Labeling of Biomolecules.J. Org. Chem., 2017, 82(3): 1471–1476.

13.Guang-hui Zheng, Jia-jia Shen, Hong Yi, Si-tu Xue, Zhen Wang, Xing-yue Ji*, and Zhuo-rong Li*. Design, synthesis and in vitro and in vivo antitumor activity of 3-benzylideneindolin-2-one derivatives, a novel class of small-molecule inhibitors of the MDM2-p53 interaction.Eur. J. Med. Chem.2014, 81: 277-88.

14.Xing-yue Ji, Si-tu Xue, Yue-chen Zhan, Jia-jia Shen, Lin-tao Wu, Jie Jin, Zhen Wang, Zhuo-rong Li. Design, synthesis and antiproliferative activity of a novel class of indole-2-carboxylate derivatives. Eur. J. Med. Chem. 2014, 83: 409–418.

15.Xingyue Ji, Krishna Damera, Yue-qin Zheng, Bing-chen Yu, Leo E. Otterbein, Bing-he Wang.Toward Carbon Monoxide–Based Therapeutics: Critical Drug Delivery and Developability Issues. J. Pharm. Sci. 2016, 105(2):406-16. (IF: 2.713, Featured article.)

16.Xing-Yue Ji, Hui-Qiang Wang, Lan-Hu Hao, Wei-Ying He, Rong-Mei Gao, Yan-Ping Li, Yu-Huan Li, Jian-Dong Jiang and Zhuo-Rong Li.Synthesis and Antiviral Activity of N-Phenylbenzamide Derivatives, a Novel Class of Enterovirus 71 Inhibitors. Molecules. 2013, 18(3): 3630-3640.

17.Xing-yue Ji, Zhao-jin Zhong, Si-tu Xue, Shuai Meng, Wei-ying He, Rong-mei Gao, Yu-huan Li* and Zhuo-rong Li*. Synthesis and antiviral activities of synthetic glutarimide derivatives. Chem. Pharm. Bull.2010, 58 (11): 1436-1441.

18. Suresh Thareja, Mengyuan Zhu, Xingyue Ji* and Binghe Wang*. Boron-based small molecules in disease detection and treatment (2013–2016). Heterocycl. Comm. 2017, DOI: 10.1515/hc-2017-0086.

19. Xingyue Ji, and Binghe Wang. Toward carbon monoxide based therapeutics: carbon monoxide in a pill. Pharm Pat Anal. 2017, 6, 171-177

20. Xingyue Ji, Si-tu Xue, Zong-ying Liu, Guang-hui Zheng, and Zhuo-rong Li*. Total synthesis of cajanine and its antiproliferative activity against human hepatoma cells. Acta. Pharm. Sin.B. 2011, 1(2): 93-99.

  

申请及授权专利

1. Wang, Binghe; Wang, Danzhu; Ji, Xingyue; Draganov, Alexander; Dai, Chaofeng; Damera, Krishna; Merlin, Didier; Viennois, Emilie; Zheng, Yueqin.Carbon monoxide-releasing molecules for therapeutic applications and methods of preparation and using thereof. PCT Int. Appl. (2015), WO 2015191616 A1 20151217. (被Pharmaceutical Patent Analyst 选为年度专利).

2. Xingyue Ji and Binghe Wang. Enzyme-triggered carbon monoxide releasing molecules.申请号：62/518,467. 2017/06/12.

3. Binghe Wang,Xingyue Ji, and Zhixiang Pan. Carbon monoxide releasing molecules. 申请号：62/510,673. 2017/05/24.

4. Xingyue Ji, Zhixiang Pan and Binghe Wang. Carbon monoxide releasing molecules triggered by physiological stimuli. 申请号：62/543,304. 2017/08/9.

5. Binghe Wang, Yueqing Zheng, Xingyue Jiand Robert E. Agogobia. Enrichment-triggered chemical delivery system. 申请号：62/577,058. 2017/10/25.

6. 季兴跃，李卓荣，薛司徒.木豆素及其类似物的制备方法，2015.05.27，中国，ZL 2010 1 0256856.7. 香港发明专利证书：HK1163653.[授权专利]

7. 李卓荣，季兴跃，薛司徒，郑光辉，李玉环，陶佩珍，蒋建东. 一组木豆素结构类似化合物、制备方法和应用，2016.08.03，ZL201110439374.X. 美国发明专利证书：US9359298B2, 2016.06.07. [授权专利]

8. 李卓荣，季兴跃，薛司徒，郑光辉，李玉环，陶佩珍，蒋建东. 一组木豆素结构类似化合物在抗丙肝病毒和抗艾滋病毒应用. CN105030750A. 2015.

9. 李卓荣，季兴跃，薛司徒，陶佩珍，王真. 取代苯并杂环类化合物及其制备方法和应用.CN102952062A .中国医学科学院医药生物技术研究所. [授权专利]. 2013

  


研究基金

1. 2017/1-2020/12,中国医学科学院医学与健康科技创新工程协同创新团队项目子课题，2017-I2M-3-012，抗慢性丙型肝炎创新药物的研究，160万元，项目负责人.

2. 1/2018-12/2021: 国家自然基金面上项目（81773608）, 靶向宿主细胞CSGalNAcT-1蛋白抗HCV药物先导物木豆素的化学蛋白质组学研究, 58.5 万元，项目负责人.

3. 1/2015-12/2017：国家青年自然科学基金 (81402827)，新型作用机制抗HCV先导物木豆素的结构优化及其构效关系的研究，23万元，项目负责人.

4. 1/2012 – 12/2013: 中央公益院所长基金, 芪类化合物的合成及广谱抗病毒活性的研究，25万元，项目负责人.