王燕

姓　　名：王燕

职称职务：教授

电子邮箱：yanwang@suda.edu.cn

办公地址：云轩楼2211室

个人简介：

一、学习工作经历

1、学历背景：

1998.9－2002.6：原苏州医学院，药学专业，医学学士学位

2002.9－2005.6：免试推荐攻读硕士学位，药理学专业，医学硕士学位

2006.9－2010.6：药理学专业，医学博士学位

2、国外学习研究经历：

2014.6－2015.6：美国斯坦福大学，医学院，博士后

二、研究方向

神经药理方向

三、主要研究成果

主持国家自然科学基金、江苏省研究生培养创新工程、18新利体育 优秀博士论文选题立项、18新利体育 青年教师研究基金的资助数项，并参与国家自然科学基金面上项目及重点项目等多项。近些年发表SCI论文二十余篇。

1、论文

(1) Liu, Z.Q., Huang S.S., Lin, M.M., Qin, S., Wu, J.C., Liang, Z.Q., Qin, Z.H., Wang, Y*. (2020). NADPH Protects against Kainic Acid-induced Excitotoxicity via Autophagy-lysosome Pathway in Rat Striatum and Primary Cortical Neurons. Toxicology, 152408.  (* corresponding author)

(2) Zhu, Y., Zhao, Y.F., Liu, R.S., Xiong, Y.J., Shen, X., Wang, Y.*, and Liang, Z.Q*. (2019). Olanzapine induced autophagy through suppression of NF-kappaB activation in human glioma cells. CNS neuroscience & therapeutics 25, 911-921.   (* corresponding author)

(3) Shen, X., Zhao, Y.F., Xu, S.Q., Wang, L., Cao, H.M., Cao, Y., Zhu, Y., Wang, Y.*, and Liang, Z.Q*. (2019). Cathepsin L induced PC-12 cell apoptosis via activation of B-Myb and regulation of cell cycle proteins. Acta pharmacologica Sinica 40, 1394-1403.   (* corresponding author)

(4) Wang, Y.*, and Le, W.D. (2019). Autophagy and Ubiquitin-Proteasome System. Advances in experimental medicine and biology 1206, 527-550.   (* corresponding author)

(5) Wang, Y.R., Qin, S., Han, R., Wu, J.C., Liang, Z.Q., Qin, Z.H., and Wang, Y*. (2013). Cathepsin L plays a role in quinolinic acid-induced NF-Kappab activation and excitotoxicity in rat striatal neurons. PloS one 8, e75702.   (* corresponding author)

(6) Dong, X.X., Wang, Y.R., Qin, S., Liang, Z.Q., Liu, B.H., Qin, Z.H., and Wang, Y*. (2012). p53 mediates autophagy activation and mitochondria dysfunction in kainic acid-induced excitotoxicity in primary striatal neurons. Neuroscience 207, 52-64.   (* corresponding author)

(7) Wang, Y., Liu, N., and Lu, B. (2019). Mechanisms and roles of mitophagy in neurodegenerative diseases. CNS neuroscience & therapeutics 25, 859-875.

(8) Wu, Z.^#, Wang, Y.^#, Lim, J., Liu, B., Li, Y., Vartak, R., Stankiewicz, T., Montgomery, S., and Lu, B. (2018). Ubiquitination of ABCE1 by NOT4 in Response to Mitochondrial Damage Links Co-translational Quality Control to PINK1-Directed Mitophagy. Cell metabolism 28, 130-144.  (^# contributed equally to this study)

(9) Feng, W.^#, Wang, Y.^#, Liu, Z.Q., Zhang, X., Han, R., Miao, Y.Z., and Qin, Z.H. (2017). Microglia activation contributes to quinolinic acid-induced neuronal excitotoxicity through TNF-alpha. Apoptosis : an international journal on programmed cell death 22, 696-709.   (^# contributed equally to this study)  

(10) Liu, E.P. ^#, Wang, Y. ^#, He, X.H., Guan, J.J., Wang, J., Qin, Z.H., and Sun, W.P. (2015). Whole Blood PCR Amplification with Pfu DNA Polymerase and Its Application in Single-Nucleotide Polymorphism Analysis. Genetic testing and molecular biomarkers 19, 610-616.   (^# contributed equally to this study)  

(11) Wang, Y., and Qin, Z.H. (2013). Coordination of autophagy with other cellular activities. Acta pharmacologica Sinica 34, 585-594.

(12) Wang, Y., and Qin, Z.H. (2010). Molecular and cellular mechanisms of excitotoxic neuronal death. Apoptosis : an international journal on programmed cell death 15, 1382-1402.  (invited review)  

(13) Wang, Y., Dong, X.X., Cao, Y., Liang, Z.Q., Han, R., Wu, J.C., Gu, Z.L., and Qin, Z.H. (2009). p53 induction contributes to excitotoxic neuronal death in rat striatum through apoptotic and autophagic mechanisms. The European journal of neuroscience 30, 2258-2270.

(14) Wang, Y., Han, R., Liang, Z.Q., Wu, J.C., Zhang, X.D., Gu, Z.L., and Qin, Z.H. (2008). An autophagic mechanism is involved in apoptotic death of rat striatal neurons induced by the non-N-methyl-D-aspartate receptor agonist kainic acid. Autophagy 4, 214-226.

(15) Wang, Y., Gu, Z.L., Cao, Y., Liang, Z.Q., Han, R., Bennett, M.C., and Qin, Z.H. (2006). Lysosomal enzyme cathepsin B is involved in kainic acid-induced excitotoxicity in rat striatum. Brain research 1071, 245-249.

(16) Wei, M., Zhu, Z., Wu, J., Wang, Y., Geng, J., and Qin, Z.H. (2019). DRAM1 deficiency affects the organization and function of the Golgi apparatus. Cellular signalling 63, 109375.

(17) Zhang, D.M., Zhang, T., Wang, M.M., Wang, X.X., Qin, Y.Y., Wu, J., Han, R., Sheng, R., Wang, Y., Chen, Z., et al. (2019). TIGAR alleviates ischemia/reperfusion-induced autophagy and ischemic brain injury. Free radical biology & medicine 137, 13-23.

(18) Zhao, Y., Shen, X., Zhu, Y., Wang, A., Xiong, Y., Wang, L., Fei, Y., Wang, Y., Wang, W., Lin, F., et al. (2019). Cathepsin L-mediated resistance of paclitaxel and cisplatin is mediated by distinct regulatory mechanisms. Journal of experimental & clinical cancer research : CR 38, 333.

(19) Zhou, Y., Wu, J., Sheng, R., Li, M., Wang, Y., Han, R., Han, F., Chen, Z., and Qin, Z.H. (2018). Reduced Nicotinamide Adenine Dinucleotide Phosphate Inhibits MPTP-Induced Neuroinflammation and Neurotoxicity. Neuroscience 391, 140-153.

(20) Luo, L., Dai, J.R., Guo, S.S., Lu, A.M., Gao, X.F., Gu, Y.R., Zhang, X.F., Xu, H.D., Wang, Y., Zhu, Z., et al. (2017). Lysosomal Proteolysis Is Associated With Exercise-Induced Improvement of Mitochondrial Quality Control in Aged Hippocampus. The journals of gerontology Series A, Biological sciences and medical sciences 72, 1342-1351.

(21) He, J.K., Wu, X.S., Wang, Y., Han, R., Qin, Z.H., and Xie, Y. (2013). Growth inhibitory effects and molecular mechanisms of crotoxin treatment in esophageal Eca-109 cells and transplanted tumors in nude mice. Acta pharmacologica Sinica 34, 295-300.

(22) Luo, L., Lu, A.M., Wang, Y., Hong, A., Chen, Y., Hu, J., Li, X., and Qin, Z.H. (2013). Chronic resistance training activates autophagy and reduces apoptosis of muscle cells by modulating IGF-1 and its receptors, Akt/mTOR and Akt/FOXO3a signaling in aged rats. Experimental gerontology 48, 427-436.

(23) Zhang, X.D., Wang, Y., Wang, Y., Zhang, X., Han, R., Wu, J.C., Liang, Z.Q., Gu, Z.L., Han, F., Fukunaga, K., et al. (2009). p53 mediates mitochondria dysfunction-triggered autophagy activation and cell death in rat striatum. Autophagy 5, 339-350.

(24) Dong, X.X., Wang, Y., and Qin, Z.H. (2009). Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases. Acta pharmacologica Sinica 30, 379-387.  

2、课题

 ①国家自然科学基金 (No.81671252)：TIGAR与NOX调控线粒体自噬和ROS在神经退行性疾病发病机制中的作用，研究经费57万元，起止日期2017.01-2020.12。项目负责人：王燕。

 ② 国家自然科学基金 (No. 81773768)：突变p53通过Egr-1/p300介导电离辐射激活Cathepsin L的机制，研究经费52万元，起止日期2018.01-2021.12。王燕排名第二。

 ③ 国家自然科学基金 (No.81000547)：神经兴奋性毒性中Cathepsin L降解IκB-a的机制及意义，研究经费20万元，起止日期2011.01-2013.12。项目负责人：王燕。

 ④国家自然科学基金 (No.30772560)：自噬参与神经兴奋性毒性的机制及药物干预，研究经费30万元，起止日期2008.01-2010.12。王燕排名第二。

3、著作

（1）主编《药理学实验教学视频》，江南电子音像出版社，2014.

（2）副主编《生命科学类创新实验训练教程》，人民卫生出版社，2018. 

（3）参编《案例药理学》，人民卫生出版社，2018.

（4）参编《药理学》，中国医药科技出版社，2016. 

（5）参编《自噬-生物学与疾病》（第二版），科学技术出版社，2015.

（6）参编《机能实验学》（双语教材），高等教育出版社，2014.

（7）参编《高等药理学》（第二版），科学技术出版社，2019.

（8）参编《Autophagy: Biology And Diseases》，Springer出版社，2019.

四、主要荣誉

2010中国神经科学学会GSK “明日之星奖”

2010 Excellent Presentation at Neuro2010

2010 苏州市优秀自然科学论文一等奖

2011 江苏省优秀博士学位论文

2012 江苏省本科优秀毕业设计一等奖指导教师

2012 江苏省药理学会青年优秀论文一等奖

2017 全国高等学校药学类专业青年教师微课教学大赛特等奖