刘艳丽

姓名：刘艳丽

职称职务：特聘教授

电子邮箱：ylliu18ATsuda.edu.cn

办公地址：云轩楼1128

一、学习工作经历

1、学历背景：

1999.09-2003.06：辽宁师范大学，生命科学学院，获理学学士学位

2003.09-2008.12：东北师范大学，生命科学学院，获理学博士学位

2、国外学习研究经历：

2012.05-2014.05，多伦多大学，结构基因组中心，访问学者、博士后

2017.04-2017.09，多伦多大学，结构基因组中心，访问教授

3、工作经历：

2009.04-2018.10，华中师范大学，生命科学学院，讲师，副教授

2018.11-至今，  18新利体育 ，特聘教授，药学院，博士生导师

二、研究方向

Ø  疾病相关蛋白质结构与功能研究

Ø  表观遗传调控相关蛋白质的结构与功能研究

Ø  基于蛋白质结构与功能的小分子药物筛选和设计

三、主要研究成果

主要从事生物大分子结构和功能研究以及基于结构的药物发现，2016年入选湖北省“青年科技晨光计划”，2019年入选江苏省“六大人才高峰”高层次人才。成功解析了50余个表观遗传相关蛋白的晶体结构，并结合其它生物化学、生物物理学和细胞生物学手段研究了相关蛋白的作用和功能。在Nat Chem Biol、Nat Commun、Pharmacol Ther、J Med Chem、Cell Chem Biol、J Biol Chem等国际主流期刊发表SCI收录论文50余篇。

1、代表性论文（*通信作者，^#共同第一作者）

Ø  Yanli Liu^*,#, Aman Iqbal^#, Weiguo Li^#, Zuyao Ni^#, Yalong Wang^#, Jurupula Ramprasad, Karan Joshua Abraham, Mengmeng Zhang, Dorothy Yanling Zhao, Su Qin, Peter Loppnau, Honglv Jiang, Xinghua Guo, Peter J Brown, Xuechu Zhen, Guoqiang Xu, Karim Mekhail, Xingyue Ji, Mark T. Bedford, Jack F. Greenblatt and Jinrong Min^*, A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II,Nat Commun, 2022, 13:5453, PMID: 36114190. (IF: 17.694/Q1)

Ø  Yanli Liu^*, Xiajie Yang, Mengqi Zhou, Yinxue Yang, Fangzhou Li, Xuemei Yan, Mengmeng Zhang, Zhengguo Wei, Su Qin, Jinrong Min^*, Structural basis for the recognition of methylated histone H3 by the Arabidopsis LHP1 chromodomain, J Biol Chem, 2022, 298(3):101623, PMID: 35074427. (IF: 5.486/Q2)

Ø  Renato Ferreira de Freitas^#, Yanli Liu^#, Magdalena M. Szewczyk, Naimee Mehta, Fengling Li, David McLeod, Carlos Zepeda-Velázquez, David Dilworth, Ronan P. Hanley, Elisa Gibson, Peter J. Brown, Rima Al-Awar, Lindsey I. James, Cheryl H. Arrowsmith, Dalia Barsyte-Lovejoy, Jinrong Min, Masoud Vedadi, Matthieu Schapira^*, Abdellah Allali-Hassani^#*, Discovery of small-molecule antagonists of the PWWP domain of NSD2, J Med Chem, 2021, 64(3): 1584-1592, PMID: 33522809. (IF: 8.039/Q1)

Ø  Mengmeng Zhang^#, Ming Lei^#, Su Qin, Aiping Dong, Ally Yang, Yanjun Li, Peter Loppnau, Timothy R. Hughes, Jinrong Min^*, Yanli Liu^*, Crystal structure of the BRPF2 PWWP domain in complex with DNA reveals a different binding mode than the HDGF family of PWWP domains, BBA - Gene Regul Mech, 2021, 1864(3): 194688, PMID: 33556623. (IF: 6.304/Q2)

Ø  Cheng Dong^#, Yanli Liu^#, Tian-Jie Lyu^#, Serap Beldar, Kelsey N. Lamb, Wolfram Tempel, Yanjun Li, Zoey Li, Lindsey I. James, Su Qin^*, Yun Wang^*, Jinrong Min^*, Structural basis for the binding selectivity of human CDY chromodomains, Cell Chem Biol, 2020, 27(7): 827-838, PMID: 32470319. (IF: 9.039/Q1)

Ø  Yanli Liu^#, Su Qin^#, Tsai-Yu Chen^#, Ming Lei^#, Shilpa S. Dhar, Jolene Caifeng Ho, Aiping Dong, Peter Loppnau, Yanjun Li, Min Gyu Lee^*, Jinrong Min^*, Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4, Nat Commun, 2019, 10: 36, PMID: 30604749. (IF: 17.694/Q1)

Ø  Yanli Liu, Su Qin, Ming Lei, Wolfram Tempel, Yuzhe Zhang, Peter Loppnau, Yanjun Li, Jinrong Min^*, Peptide recognition by heterochromatin protein 1 (HP1) chromoshadow domains revisited: Plasticity in the pseudosymmetric histone binding site of human HP1, J Biol Chem, 2017, 292(14): 5655-5664, PMID: 28223359. (IF: 5.486/Q2)

Ø  Yanli Liu, Li Li, Jinrong Min^*, Structural biology: HDAC6 finally crystal clear, Nat Chem Biol, 2016, 12(9): 660-661, PMID: 27538024. (IF: 16.174/Q1)

Ø  Yanli Liu, Wolfram Tempel, Qi Zhang, Xiao Liang, Peter Loppnau, Su Qin^*, Jinrong Min^*, Family-wide characterization of histone binding abilities of human CW domain-containing proteins,J Biol Chem, 2016, 291(17): 9000-9013, PMID: 26933034. (IF: 5.486/Q2)

Ø  Yanli Liu^#, Ke Liu^#, Su Qin, Chao Xu, Jinrong Min^*, Epigenetic targets and drug discovery Part 1: histone methylation, Pharmacol Ther, 2014, 143(3): 275-294, PMID: 24704322. (IF: 13.400/Q1)

Ø  Su Qin^#, Yanli Liu^#, Wolfram Tempel, Mohammad S. Eram, Chuanbing Bian, Ke Liu, Guillermo Senisterra, Lissete Crombet, Masoud Vedadi, Jinrong Min^*, Structural basis for histone mimicry and hijacking of host proteins by influenza virus protein NS1, Nat Commun, 2014, 5: 3952, PMID: 24853335. (IF: 17.694/Q1)

Ø  Jie Zhang, Yijun Yang, Xinhua Li, Gen Li, Takuya Mizukami, Yanli Liu, Yuan Wang, Guoqiang Xu, Heinrich Roder, Li Zhang, and Zeng-jie Yang, PDLIM3 supports hedgehog signaling in medulloblastoma by facilitating ciliary formation, Cell Death Differ,2023, doi: 10.1038/s41418-023-01131-2, PMID: 36813922. (IF: 12.0736/Q1)

Ø  Yibo Zuo, Zhijin Zheng, Yingkang Huang, Jiuyi He, Lichao Zang, Tengfei Ren, Xinhua Cao, Ying Miao, Yukang Yuan, Yanli Liu, Feng Ma, Jianfeng Dai, Sheng Tian, Qiang Ding, Hui Zheng, Vitamin C promotes ACE2 degradation and protects against SARS-CoV-2 infection, EMBO Rep, 2023, e56374, PMID: 36876523. (IF: 9.4207/Q1)

Ø  David Dilworth^#*, Ronan P. Hanley^#, Renato Ferreira de Freitas^#, Abdellah Allali-Hassani^#, Mengqi Zhou^#, Naimee Mehta, Matthew R. Marunde, Suzanne Ackloo, Raquel Arminda Carvalho Machado, Aliakbar Khalili Yazdi, Dominic D. G. Owens, Victoria Vu, David Y. Nie, Mona Alqazzaz, Edyta Marcon, Fengling Li, Irene Chau, Albina Bolotokova, Su Qin, Ming Lei, Yanli Liu, Magdalena M. Szewczyk, Aiping Dong, Sina Kazemzadeh, Tigran Abramyan, Irina K. Popova, Nathan W. Hall, Matthew J. Meiners, Marcus A. Cheek, Elisa Gibson, Dmitri Kireev, Jack F. Greenblatt, Michael-C. Keogh, Jinrong Min, Peter J. Brown, Masoud Vedadi, Cheryl H. Arrowsmith, Dalia Barsyte-Lovejoy^*, Lindsey I. James^* and Matthieu Schapira^*, A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization, Nat Chem Biol,2022, 18(1):56-63, PMID: 34782742. (IF: 16.174/Q1)

Ø  Daohai Du^#, Dandan Xu^#, Licheng Zhu^#, Giulia Stazi, Clemens Zwergel, Yanli Liu, Zhongyuan Luo, Yuanqing Li, Yuanyuan Zhang, Kongkai Zhu, Yiluan Ding, Jingqiu Liu, Shijie Fan, Kaiyan Zhao, Naixia Zhang, Xiangqian Kong, Hualiang Jiang, Kaixian Chen, Kehao Zhao, Sergio Valente^*, Jinrong Min^*, Wenhu Duan^*, Cheng Luo^*, Structure-guided development of small-molecule PRC2 inhibitors targeting EZH2-EED interaction, J Med Chem, 2021, 64(12): 8194-8207, PMID: 34077206. (IF: 8.039/Q1)

Ø  Renata Z. Jurkowska^#, Su Qin^#, Goran Kungulovski, Wolfram Tempel, Yanli Liu, Pavel Bashtrykov, Judith Stiefelmaier, Tomasz P. Jurkowski, Srikanth Kudithipudi, Raluca Tamas, Hong Wu, Ludmila Dombrovski, Peter Loppnau, Richard Reinhardt, Jinrong Min^*, Albert Jeltsch^*, H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1, Nat Commun, 2017, 8: 2057, PMID: 29234025. (IF: 17.694/Q1)

Ø  Jacob I Stuckey, Bradley M Dickson, Nancy Cheng, Yanli Liu, Jacqueline L Norris, Stephanie H Cholensky, Wolfram Tempel, Su Qin, Katherine G Huber, Cari Sagum, Karynne Black, Fengling Li, Xi-Ping Huang, Bryan L Roth, Brandi M Baughman, Guillermo Senisterra, Samantha G Pattenden, Masoud Vedadi, Peter J Brown, Mark T Bedford, Jinrong Min, Cheryl H Arrowsmith, Lindsey I James^*, Stephen V Frye^*,A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1, Nat Chem Biol,2016, 12(3): 180-187, PMID: 26807715. (IF: 16.174/Q1)

2、科研项目

Ø  国家自然科学基金面上项目（32271309）

Ø  国家自然科学基金青年项目（31500613）

Ø  湖北省自然科学基金（2009CDB234）

四、主要荣誉和获奖情况

Ø  湖北省“青年科技晨光计划”，2016年，生物化学与分子生物学

Ø  江苏省“六大人才高峰”高层次人才，2019年，生物技术和新医药产业

Ø  “青年科学家论坛”三等奖，生物化学与分子生物学会2019年全国学术会议

五、社会兼职

湖北省生物物理学会理事；湖北省实验动物学会理事；中国细胞生物学学会会员；中国生物化学与分子生物学会会员；湖北省晶体学会会员；湖北省生物化学与分子生物学会会员；
Associate Editor: Heliyon (IF: 3.776/Q2)
 Invite Reviewer: Nat Commun (IF: 17.694/Q1), Nat Struct Mol Biol (IF: 18.36/Q1), Cell Mol Life Sci (IF: 9.235/Q1), BBA - Gene Regul Mech (IF: 6.304/Q2), Structure (IF: 5.188/Q2), BBA-Mol Cell Res (IF: 5.011/Q2), Heliyon (IF: 3.776/Q2)