神经18新利备用网站 所学术报告

报告题目：Spinal circuits transmitting and gating mechanical pain

报告人: 马秋富 教授（Harvard Medical School）

报告时间: 2016年5月16日（周一）15:00

报告地点:神经18新利备用网站 所会议室401-1500

主持人：徐广银 教授

报告人简介

Dr. Qiufu Ma

Professor, Department of Neurobiology, Harvard Medical School and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA

PERSONAL STATEMENT. My colleagues and I have been working on the development and functions of the somatic sensory circuits since 1995. Major contributions include the identification of i) Neurogenin1 that controls genesis of peripheral nociceptors, ii) Runx1 that controls the expression of many sensory channelsand receptors responding to painful or pruritic stimuli, and iii) Tlx3 that controls the formation of dorsal spinalexcitatory neurons that relay pain- and itch-related information to the brain. In recent years, my lab is increasingly interested in studying how pain and itch are encoded. To this end, we have revealed a group of peripheral nociceptors required to sense pain and suppress itch, removal of which leads to the creation of a mouse model of chronic neurogenic itch. Most recently, our lab has been using intersectional genetic manipulations to mark and ablate a large cohort of excitatory and inhibitory neurons in the dorsal spinal cord. Subsequent behavioral and electrophysiological studies have started to provide insight into spinal microcircuits processing pain or itch. It is our hope that these studies will eventually provide new ideas to treat chronic pain or itch.

SELECTED PUBLICATIONS

1. Ma Q, Kintner C, and Anderson DJ. Identification of neurogenin, a vertebrate neuronal determination gene. Cell 1996; 87: 43-52.
2. Ma Q, Chen Z, Barrantes J, de la Pompa, J, and Anderson DJ. neurogenin1 plays an essential role in the determination of sensory neuron precursors for proximal cranial ganglia. Neuron 1998; 20: 469-482.
3. Cheng L, Arata A, Karunaratne A, Qian Y, Mizuguchi R, Gray PA, Arata S, Shirasawa S, Bouchard M, Luo P, Chen C, Busslinger M, Goulding M, Onimaru H, and Ma Q. Tlx3 and Tlx1 are post-mitotic selector genes determining glutamatergic over GABAergic cell fates. Nature Neuroscience 2004; 7: 510-7.
4. Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, and Ma Q. Mouse brain organization revealed through direct genome-scale TF expression analysis. Science 2004; 306: 2255-7.
5. Cheng L, Samad OA, Xu Y, Mizuguchi R, Luo P, Shirasawa S, Goulding M, and Ma Q. Lbx1 and Tlx3 are opposing switches in determining GABAergic versus glutamatergic transmitter phenotypes. Nature Neuroscience 2005; 8: 1510-5.
6. Ma YC, Song MR, Park JP, Henry Ho HY, Hu L, Kurtev MV, Zieg J, Ma Q, Pfaff SL, Greenberg ME. Regulation of motor neuron specification by phosphorylation of neurogenin 2. Neuron 2008; 58: 65-77
7. Liu Y, Abdel Samad O, Duan B, Zhang L, Tong Q, Lopes C, Ji RR, Lowell B, and Ma Q. VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch. Neuron 2010; 68:543-56. PMCID: PMC2991105.
8. Ma Q. Merkel cells are a touchy subject. Cell 2014; 157(3):531-3.
9. Duan B, Cheng L, Bourane S, Britz O, Padilla C, Garcia-Campany L, krashes M, Knowlton, W, Ren Y, Ross S, Lowell BB, Wang Y, Goulding M, and Ma Q. Identification of Spinal Circuits Transmitting and Gating Mechanical Pain. Cell 2014;159:1417-32. PMCID: PMC4258511
10. Bourane S*, Duan B*, Koch S, Dalet A, Britz A, Garcia-Campmany L, Kim E, Cheng L, Ghosh A, Ma Q#, and Goulding M#. Gate control of mechanical itch by a subpopulation of spinal cord interneurons. Science 2015;350:550-4 (#co-corresponding authors).

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                                                                                                                                                   2016-05-13