题目：Pain and gain of Nav1.7 sodium channel

报告人： Yang Yang, Ph.D.

Yale University School of medicine

报告时间：2015年9月28日（周一）16：00

报告地点： 18新利体育 神经18新利备用网站 所会议室

报告人简介：

Education and experience:

Position: Associate Research Scientist

Research focus: Using stem cell and noninvasive recording approaches to understand the contributions of voltage-gated sodium channels in painful neuropathy

Institution: Yale University School of Medicine/Veterans Affairs Connecticut Healthcare System, New Haven, CT (2014-present)

Position: Postdoctoral Fellow

Research focus: Structure and function of voltage-gated sodium channels in chronic pain

Mentor: Dr. Stephen G. Waxman

Institution: Yale University School of Medicine/Veterans Affairs Connecticut Healthcare System, New Haven, CT (2011-2014)

Degree: Doctor of Philosophy

Major: Cellular Molecular Biology & Physiology

Mentor: Dr. Chun Jiang

Institution: Georgia State University, Atlanta, GA (2005-2011)

Degree: Bachelor of Science; Bachelor of Arts

Major: Life Sciences; Second major: Sociology

Mentors: Dr. Fuxue Chen (Life Sciences); Dr. Youde Zhang (Sociology)

Institution: Shanghai University, Shanghai, China (2001-2005)

Position: Teaching Assistant, Georgia State University (2007-2011)

Courses and supervisor: Introductory Biology (6 sections), Dr. David Blaustein

Molecular Cell Biology Lab (3 sections), Dr. Therese Poole

Research Support:

1. Project title: Modeling Chronic Pain Condition with iPS Cells from Patients with "Man on Fire" Syndrome for Better Pharmaco-Genomic Analysis and Drug Testing

Agency: State of Connecticut Stem Cell Research Fund; Type: Seed Grant;

Role: Co-Principal Investigator

Project Timeframe: 9/1/2013-10/31/2015; Total Funding: $200,000

2. Project title: Structure and ligand based virtual drug screening of Nav1.7 voltage-gated sodium channel binding natural products as scaffolds for next-generation pain relief

Agency: Yale Center for Molecular Discovery; Type: Pilot Project;

Role: Principal Investigator

Project Timeframe: 4/1/2014-3/31/2015; Total Funding: 200% spending matching

Publications:

1. Yang Y, Vasylyev DV, Dib-Hajj F, Veeramah KR, Hammer MF, Dib-Hajj SD, Waxman SG. Multi-state structural modeling and voltage-clamp analysis of epilepsy/autism mutation Kv10.2-R327H demonstrate the role of this residue in

stabilizing the channel closed state, Journal of Neuroscience 2013, 33(42):16596-93

2. Huang J*, Yang Y*, Dib-Hajj SD, van Es M, Zhao P, Salomon J, Drenth JP, Waxman SG. Depolarized inactivation overcomes impaired activation to produce DRG neuron hyperexcitability in a Nav1.7 mutation in a patient with distal limb pain, Journal of Neuroscience 2014, 34(37):12328-40

3. Yang Y*, Jin X, Jiang C. S-glutathionylation of ion channels: insights into the regulation of channel functions, thiol modification crosstalk, and mechanosensing, Antioxidants & Redox Signaling 2014, 20(6):937-51

4. Yang Y, Estacion M, Dib-Hajj SD, Waxman SG. Molecular architecture of a sodium channel S6 helix: radial tuning of the Nav1.7 activation gate, Journal of Biological Chemistry 2013, 288 (19): 13741-475．

5. Yang Y*, Konduru AS, Cui N, Yu L, Trower TC, Shi W, Shi Y, Jiang C. Acute exposure of methylglyoxal leads to activation of KATP channel expressed in HEK293 cells, Acta Pharmacologica Sinica (a Nature Publishing Group journal) 2014, 35:58-64