王玉田院士报告会
时间: 2015-07-07 作者: 浏览次数: 0

报告题目：Translational medicine research – lessons from the development of  neuroprotectants for stroke treatment

报告人: 王玉田 教授、院士

报告时间: 2015年7月10日（周五）16:00

报告地点:神经18新利备用网站 所会议室

主持人：徐广银 教授

 

报告人简介：

Dr. Yu Tian Wang, Professor and the holder of the Heart and Stroke Foundation of B.C. & Yukon Chair in Stroke Research in the Department of Medicine and the Brain Research Centre at the University of British Columbia, obtained his Ph.D. in Neuroscience in 1992 from Memorial University, Canada and both B.M. (Medicine) in 1982 and M.Sc. (Physiology) in 1985 from Shandong University Medical School in China.  He worked in Department of Laboratory Medicine and Pathobiology at University of Toronto as an Assistant Professor, and then an Associate Professor between 1994 and 2001.  He was also a Howard Hughes Medical Institute International Scholar between 2001-2011 and has been a Fellow of the Academy of Sciences of Royal Society of Canada since 2006. Dr. Wang’s research focuses on understanding the molecular mechanisms responsible for regulating the function and intracellular trafficking of glutamate and GABA receptors in brain function such as learning and memory and investigating the manner by which these mechanisms may be altered in central nervous disease processes. The ultmate goal is to be able to design new therapeutics that specifically target these receptors and their pathways to treat central nervous disorders such as stroke, cognitive impairments, drug addiction and schizophrenia.

 

Representative publications:

  1. Wang YT and MW Salter, Regulation of NMDA receptors by protein-tyrosine kinases and phosphatases, Nature, 369:233-235, 1994.
  2. Wan Q, Xiong ZG, Man HY, Ackerley CA, Braunton J, Lu WY, Becker LE, MacDonald JF and YT Wang, Recruitment of functional GABAA receptors to postsynaptic domains by insulin, Nature, 388:686, 1997.
  3. Liu F, Wan Q, Pristupa Z, Wang YT* and Niznik HB* (*equal corresponding authors) Direct protein-protein binding enables reciprocal dopamine D5 and GABAA receptor cross talk, Nature (Article), 403:274-280, 2000.
  4. HY Man, J Lin, W Ju, G Ahmadian-Bahadorani, LE Becker, M Sheng and YT Wang, Regulation of AMPA receptor-mediated synaptic transmission by clathrin-dependent receptor internalization, Neuron, 25:649-662, 2000.
  5. Lu WY, Man HY, Trimble W, MacDonald JF and YT Wang, Activation of synaptic NMDA receptors induces LTP through insertion of AMPA receptors at excitatory synapses in cultured hippocampal neurons, Neuron, 29:243-254, 2001.
  6. Collingridge GL, JTR Isaac, YT Wang, Receptor trafficking and synaptic plasticity, Nature Neuroscience Rev. 5:952-962, 2004.
  7. Liu L, TP Wong, MF Pozza, K Lingenhoehl, Y Wang, M Sheng, YP Auberson, YT Wang, Subtypes of NMDA receptors govern the direction of hippocampal synaptic plasticity, Science, 304:1021, 2004.
  8. Brebner K, TP Wong, L Liu, Y Liu, P Campsall,  S Gray, L Phelps, AG Phillips*, YT Wang* (*equal corresponding authors), Nucleus Accumbens Long-Term Depression and the Expression of Behavioral Sensitization, Science, 310:1340-1343, 2005.
  9. Taghibiglou C, HGS Martin, TW Lai, T Cho, S Prasad, L Kojic, J Lu, Y Liu, E Lo, S Zhang, YP Li, JZZ Wu, YH Wen,  JH Imm, M Cynader and YT Wang, Role of NMDA receptor-dependent activation of SREBP1 in excitotoxic and ischemic neuronal injuries, Nature Medicine, 15:1399-1406, 2009.
  10. Fan X, Jin WY, Lu J, Wang J and YT Wang, Rapid and reversible knockdown of endogenous proteins by peptide-directed lysosomal degradation, Nature Neurosci., 17:471-480, 2014.

 

 

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                                                   2015-07-07