报告题目： Striatal Roles in Action Control and Action/Habit Learning
报告人： David M. Lovinger, Ph.D.
报告时间：2014年10月30日（周四）上午10:00
报告地点：18新利体育 神经18新利备用网站 所会议室
主持人：徐广银 教授
报告人简介:
A、Personal Statement
I am a senior neuroscientist working in the Division of Intramural Clinical and Biological Research at NIAAA/NIH. My research focuses on the roles of cortical and basal ganglia neuronal and circuit function in action control and action learning. Our laboratory also examines alcohol effects on this circuitry, and the role of this system in alcohol seeking and drinking. We have extensive experience in studies of striatal synaptic plasticity, investigation of the role of the dorsal striatum in habit learning, and the effects of alcohol in this brain region.
B. Positions and Honors
Research and Professional Positions
1987-88: Intramural Research Training Award (IRTA) Fellow. Fellowship administered by NINCDS. Supervisor: Dr. Forrest F. Weight, Section of Electrophysiology, Laboratory of Physiologic and Pharmacologic Studies, National Institute on Alcohol Abuse &Alcoholism, 12501 Washington Ave., Rockville, MD 20852.
1988-1990: Staff Fellow, NIAAA, 12501 Washington Ave., Rockville, MD 20852. Supervisor: Dr. Forrest F. Weight.
1990-1991: Chief, Unit of Synaptic Pharmacology, Laboratory of Physiologic and Pharmacologic Studies, NIAAA, 12501 Washington Ave., Rockville, MD 20852.
1991-1994: Assistant Professor, Department of Molecular Physiology and Biophysics, Vanderbilt Univ School of Medicine, 702 Light Hall, Nashville, TN 37232-0615.
1994-1998: Associate Professor, Molecular Physiology and Biophysics, Vanderbilt Univ School of Medicine
1998-2002: Professor, Molecular Physiology and Biophysics, Vanderbilt Univ School of Medicine
2002-Present: Chief, Laboratory for Integrative Neuroscience, NIAAA Division of Intramural Clinical and Biological Research
2013-Present: Deputy Scientific Director, NIAAA Division of Intramural Clinical and Biological Research
Other Experiences and Professional Memberships (selected)
Ad Hoc reviewer for NIAAA/ADAMHA ALCB-2 study section, October 1993, February 1994.
Ad Hoc reviewer for NIH review groups including: MDCN-3, Fall 2001; MDCN-4, Spring 2003; and SYN, Winter 2006.
Member of ALCB-2 study section beginning in 1995. Changed name to ALTX-3 in 1996. Service completed in June 1998.
Ad Hoc reviewer for special NIH review panels 1997, 1998 and 2000, 2004, 2007, 2008, 2009.
Participant in NIAAA Neuroscience and Behavior portfolio review, May 1998.
Member, Scientific Advisory Board, Dystonia Medical Research Foundation, 2005.
Member, NIH intramural Central Tenure Committee, 2010-present.
Member of Research Society on Alcoholism program committee, 1993, 1997, 2000, 2003, 2005 and 2006.
Co-organized and chaired sessions in “The 5-HT3 Receptor: A model Cys-Loop Ligand-Gated Ion Channel”, a satellite symposium for the 2005 Society for Neuroscience meeting, Washington, DC, November 2005.
Co-Chair, Gordon Research Conference on Cannabinoid Function in the CNS, August 2013.
Co-Chair, Gordon Research Conference on Alcohol and the Nervous System, February 2014.
Honors:
1984: Walter Dill Scott Summer Research Fellowship, Northwestern University
1989: National Research Council Travel Award to attend the International Congress of Physiological Sciences
1992: Woodrow W. Patterson Award
1992: Research Society on Alcoholism Young Investigators Award
2000: MERIT Award, NIAAA
2008: Alexander D. Kenny Memorial Lectureship, Texas Tech Health Sciences University
2014: Bowles Center for Research Excellence Award, from the University of North Carolina, Chapel Hill.
2014: NIH Director’s Award
C. Selected peer-reviewed publications (Selected from more than 100 total):
Choi, S. and Lovinger, D.M. (1997) Decreased probability of neurotransmitter release underlies striatal LTD and postnatal development of corticostriatal synapses. Proc. Natl. Acad. Sci., 94:2669-2670.
Gerdeman, G. and Lovinger, D.M. (2002) Postsynaptic endocannabinoid release is necessary for long-term depression in the striatum. Nature Neuroscience, 5(5):446-451.
Wang, Z., Kai, L., Day, M., Ronesi, J., Yin, H.H., Ding, J., Tkatch, T., Lovinger, D., and Surmeier, D.J. (2006) Dopaminergic control of corticostriatal long-term synaptic depression in medium spiny neurons is mediated by cholinergic interneurons. Neuron, 50: 443-452.
Dang, M., Yokoi, F., Yin, H.H., Lovinger, D.M., Wang, Y.Y. and Li, Y. (2006) Disrupted motor learning and long-term synaptic plasticity in mice lacking NMDAR1 in the striatum. Proc. Nat’l Acad. Sci. USA, 103(41): 15254-15259.
Adermark, L. and Lovinger, D.M. (2007) Combined activation of L-type Ca2+ channels and synaptic transmission is sufficient to induce striatal long-term depression. J. Neurosci., 27(25):6781-6787.
Adermark, L. and Lovinger, D.M. (2007) Retrograde Endocannabinoid signaling at striatal synapses requires a regulated postsynaptic release step. Proc. Natl. Acad. Sci. USA, 104(51):20564-20569.
Yin, H.H., Mulcare, S.P., Hilario, M.R.F., Clouse, E., Holloway, T., Davis, M.I., Hansson, A.C., Lovinger, D.M. and Costa, R.M. (2009) Dynamic reorganization of striatal circuits during the acquisition and consolidation of a skill. Nat. Neurosci., 12(3):333-341.
Bello, E., Mateo. Y., Shin, J.H., Alvarez, V.A., Lovinger., D.M. and Rubinstein. M. (2011) Selective loss of dopamine D2 autoreceptors reveals a crucial role for the presynaptic regulation of dopamine release in the CNS. Nature Neuroscience, 14(8):1033-1038.
Cachope, R., Mateo, Y., Mathur, B.N., Irving, J., Wang, H-L., Morales, M. Lovinger, D.M. and Cheer, J.F. (2012) Selective activation of cholinergic interneurons enhances accumbal phasic dopamine release: setting the tone for reward processing. Cell Reports, 2, available online.
Cui, G.#, Jun, S.B.#, Jin, X., Pham, M.D., Vogel, S.S.&, Lovinger, D.M.& and Costa, R.M.& (2013) Concurrent activation of striatal direct and indirect pathways during action initiation. Nature, 494(7436):238-42. #Authors contributed equally, &Co-corresponding authors.
Mathur, B.N., Tanahira, C., Tamamaki, N. and Lovinger, D.M. (2013) Voltage drives diverse endocannabinoid signals to mediate striatal microcircuit-specific plasticity. Nature Neuroscience, 16(9), 1275-1283.
Zhou, Z., Liang, T., Tapocik, J., Kimura, M., Yuan, Q., Xiong, W., Barbier, E., Karlsson, C., Feng, A., Enoch, M-A., Hodgkinson, C.A., Lovinger, D.M., Edenberg, H., Heilig, M., and Goldman, D. (2013) Loss of Metabotropic Glutamate Receptor 2 Escalates Alcohol Consumption. Proc. Nat’l. Acad. Sci. USA, 110(42): 16963-16968.
Atwood, B.K., Kupferschmidt, D.A. and Lovinger, D.M. (2014) Opioids induce dissociable forms of long-term depression of excitatory inputs to the dorsal striatum. Nature Neuroscience, 17(4): 540-548.
Cui, G., Jun, S.B., Jin, X., Luo, G., Pham, D., Lovinger, D.M., Vogel, S.S. and Costa, R.M. (2014) Deep brain optical measurements of cell type-specific neural activity in behaving mice. Nature Protocols, 9(6): 1213-1228.
Atwood, B.K., Lovinger, D.M. and Mathur, B.N. (2014) Presynaptic long-term depression mediated by Gi/o-coupled receptors. Trends Neurosci., advance e-publication available online.
D. Research Support
LOVINGER, D.M.
ONGOING
NIH/NIAAA Division of Intramural Clinical and Basic Research. Direct support for Section on Synaptic Pharmacology.
02/2002-Present 100% effort
Overseeing research in the Laboratory for Integrative Neuroscience and the Section on Synaptic Pharmacology. Includes direct participation in neuroscience research, supervising and training staff scientists, research assistants and fellows, as well as recruitment and career development of tenure track faculty.
COMPLETED
R37 AA08986 (Lovinger) 04/01/2000-03/31/2005 30%
NIH
Ethanol Inhibition of NMDA Receptor-Mediated Responses
These studies focussed on the relationship between NMDA receptor structure and EtOH sensitivity. Experiments examined EtOH effects on NMDA receptor function in gene-targeted mice that lacked particular NMDAR subunits, and in cells expressing point-mutated NMDA receptors.
RO1 NS36758 (Delpire) 07/30/1999-04/30/2003 5%
NIH
Molecular Physiology of Brain Cation-Cl Cotransporters
These studies examined the role of Cl- transporters in the developmental shift from depolarizing to hyperpolarizing GABAA receptor-mediated responses in brain neurons.
R21 AA11542 (Lovinger) 04/01/2000-03/31/2002 12%
NIH
Molecular Basis of Ethanol Effects on 5-HT3 Receptors
This study was designed to examine the structure of 5-HT3 ligand-gated ion channels using site-directed spin-labeling and EPR. Effects of EtOH on receptor structure were also planned.
R01 HL43671 (Limbird) 06/01/2000-05/31/2004 5%
NIH/NHLBI (HL)
In vivo Relevance of Various alpha2AR Trafficking Itineraries
These studies were designed to examine the cell surface localization and coupling to ion channels of different alpha2A adrenergic receptors.
P30 HD15052 (Camarata, S) 07/01/1999-06/30/2004 3%
NIH
John F. Kennedy center for mental retardation
This was a large umbrella center grant that supported several service cores used for studies of development as it relates to cognitive function. Dr. Lovinger's role was to oversee the Neuroscience Core facilities.
R01 MH63232 (Colbran) 04/01/2001 -03/31/2006 5%
NIH
Mechanisms of Cam Kinase II Signal Transduction
These studies examined the effect of CAMKII binding on the function of NMDA-type glutamate receptors.
R01 NS30470 (Lovinger) 03/01/1997-02/28/2002 1%
NIH
Excitatory Synaptic Transmission in Neostriatum
These studies focused on modulation and plasticity of glutamatergic synaptic transmission in the striatum. Studies also examined the role of postsynaptic dopamine receptors in striatal synaptic plasticity.
R01 NS37615 (Ikeda-Guthrie Foundation) 09/01/1997-05/31/2001 0%
NIH
Physiological Roles of Glutamate Metabotropic Receptors
Subcontract with the Guthrie Foundation