报告题目：The Novel Role of the NMDA Receptor Subunit GluR3A (NR3A) in Neurological Function

报告人: Shan Ping Yu, M.D., Ph.D.

报告时间: 2014年10月14日（周二）上午10:00

报告地点: 18新利体育 神经18新利备用网站 所会议室

主持人：徐广银 教授

报告人简介：

Dr. Shan Ping Yu is a Professor and the O. Wayne Rollins Endowed Chair at Emory University School of Medicine. Dr. Yu's research has been focused on the mechanism of neuronal cell death and neuroprotection after hypoxia and ischemia in vitro as well as in animal models. His investigations contributed to the identification of novel ionic and molecular mechanisms that involve voltage-gated channels and ligand-gated receptors in apoptotic and necrotic cell death. His research group was among the first to develop the novel concept of preconditioning transplanted stem cells and have demonstrated the multifaceted pro-survival and pro-regenerative effects of this strategy in stem cell transplantation therapy. Dr. Yu developed the novel pharmacological hypothermia therapy and demonstrated its brain protective effects against ischemic stroke, hemorrhage stroke and traumatic brain injury. Dr Yu has published over 100 peer-reviewed papers in in top tier journals such as Science, PNAS, J. Neuronsci, Neurobiol Dis, JCS, Stem Cells and FASEB J. Dr. Yu’s research has been supported by multiple grants from NIH, NSF, and AHA. He is an editorial board member of several journals and has serviced as a regular or invited study section member for NIH, VA, AHA and several international institutions.

Representative publications:

1、Yu, S.P. et al, Mediation of neuronal apoptosis by enhancement of outward potassium current. Science 278: 114-117, 1997

2、Yu, S.P. et al., NMDA receptor mediated K+ efflux and neuronal apoptosis. Science  284: 336-339, 1999

3、Xia, S., Lampe, P.A., Deshmukh, M., … & Yu, S.P. Multiple channel interactions explain the protection of sympathetic neurons from apoptosis induced by NGF deprivation. J. Neurosci. 22: 114-122, 2002.

4、Wang, X.Q., Xiao, A.Y., Sheline, C., …. & Yu, S.P. Apoptotic insults impair Na+, K+-ATPase activity as a mechanism of neuronal death mediated by concurrent ATP deficiency and oxidative stress. J. Cell Science 116:2099-2110, 2003.

5、Cui L, Jiang J, Wei L, …. & Yu SP. Transplantation of embryonic stem cells improves nerve repair and functional recovery after severe sciatic nerve axotomy in rats. Stem Cells. 26(5):1356-65, 2008.

6、Hu, X., Wei, L., Wang, …. & Yu, S.P. Hypoxic preconditioning enhances bone marrow mesenchymal stem cell migration via Kv2.1 channel and FAK activation, Am J Physiol, 301(2):C362-C372, 2011

7、Zhou, X., Wei, J., Francis, K.R. & Yu, S.P., Novel role of KCNQ2/3 channels in regulation of neuronal cell viability, Cell Death and Different. 18:493-505, 2011.

8、Choi, K-E.,  Hall, C.L., Sun, J-M., …. & Yu, S.P. A novel stroke therapy of pharmacologically induced hypothermia after cerebral ischemia in mice. FASEB J.,  26:2799-2810, 2012.

9、Song, M., Mohamad, O., Gu, X., Wei, L. & Yu, S.P. Restoration of intracortical and thalamocortical circuits after transplantation of bone marrow mesenchymal stem cells into the ischemic brain of mice. Cell Transplantation, 22(11):2001-2015, 2013.

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