报告题目： Cognitive dysfunction in rodent models of psychiatric disorders

报告人： Mu Sun, PhD

报告时间：2013年12月12日（周四）上午10：00

报告地点：18新利体育 神经18新利备用网站 所会议室

报告人简介：

Mu Sun, PhD

EDUCATION:：

09/1999--07/2002,    Jilin University/University of Hamburg, Germany.

Doctor of Philosophy in Physiology

09/1996-- 07/1999,    Jilin University, School of Medicine, China.

Master of Medical science

09/1989-- 07/1994,    Central South University, Xiangya School of Medicine, China.

Bachelor of Clinical Medicine.

EMPLOYMENT:

07/2012-06/2013,    Visiting Scientist (non-paid position), Faculty of Life Sciences, University of Manchester, UK Manage collaborations on cognitive science.

08/2010- present,    Senior Scientist, Group leader of electrophysiology platform

Dept. of Neurodegeneration, R&D, GSK

Major responsibilities:

Lead electrophysiological efforts for GSK’s neuroscience therapeutic area with ND DPU, NI DPU and RM DPU in Alzheimer’s disease, Parkinson disease, multiple sclerosis and chemo-induced peripheral neuropathy.

Major achievements:

Develop SOPs for electrophysiological assays. Coordinate with multiple project leaders to prioritize projects and achieve timely delivery for neuroscience pipeline. Bring two compounds to Candidate selection and one compound to First time in Human; One active project from target identification to start-of-chemistry to pre-candidate selection.

04/2010- 08/2010,    Senior Scientist, Dept. of Innovative Research, GSK,

Team leader of Synaptic Plasticity and Learning.

Projects: Target validation on disease modifying targets for Alzheimer’s disease, such as ion channels and GPCRs etc.

04/2008-- 03/2010, Research Specialist I & 04/2003--03/2008 Research Associate Howard Hugths Medical Institute/Univercity of Minnesota, Medical School, Department of Genetics, Cell biology and Development, USA.

01/2000--04/2003,    Center for Molecular Neurobiology, Institute for the Biosynthesis of Neural Structures, University Medical Center Hamburg-Eppendorf, University of Hamburg, Germany

SELECTED PUBLICATIONS

1. Yamanaka N, Romero NM, Martin FA, Rewitz KF, Sun M, O'Connor MB, Léopold P. (2013) Neuroendocrine Control of Drosophila Larval Light Preference. Science, 2013 Sep 6;341(6150):1113-6.

2.  L, Sun M, Gewirtz JC, & Georgieff MK. (2013) Iron Deficiency with or without Anemia Impairs Prepulse Inhibition of the Startle Reflex. Hippocampus, Jun 3. doi: 10.1002/hipo.22151. [Epub ahead of print]

3.  Xu X, Lei Y, Luo J, Wang J, Zhang S, Yang XJ, Sun M, Nuwaysir E, Fan G, Zhao J, Lei L, Zhong Z (2013) Prevention of beta-amyloid induced toxicity in human iPS cell-derived neurons by inhibition of Cyclin-dependent kinases and associated cell cycle events. Stem Cell Res 10:213-227.

4. Sun, M., Forsman, C., Sergi, C., Gopalakrishnan, R., O'Connor, M.B., and Petryk, A. (2010) The expression of twisted gastrulation in postnatal mouse brain and functional implications. Neuroscience 169, 920-931

5. Sun, M., Gewirtz, J.C., Bofenkamp, L., Wickham, R.J., Ge, H., and O'Connor, M.B. (2010) Canonical TGF-beta signaling is required for the balance of excitatory/inhibitory transmission within the hippocampus and prepulse inhibition of acoustic startle. J Neurosci 30, 6025-6035.