报告题目：Functions of Noncoding RNAs in Central Nervous System Development and Disease
报告人: 孙涛 博士
报告时间: 2011年3月15日（周二）14:00
报告地点: 18新利体育
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孙涛 简介：
孙涛，康奈尔大学威尔医学院细胞与发育生物学系助理教授。研究方向：1.神经干细胞和神经再生；2.神经系统发育和人类神经疾病的遗传机制；3.非编码RNA的基因治疗。报告摘要如下：
The proper development and function of the human brain is controlled by precise regulation of gene expression.Many human neurological disorders, such as epilepsy, schizophrenia and autism, are associated with abnormal structural formation and connection in developing brain. The causes of these neurological disorders are poorly understood.
In my lab, we are examining a novel gene regulation mechanism that is essential in normal brain development and under disease conditions. We have found that noncoding small RNAs, called microRNAs (miRNAs), play a critical role in controlling the brain size. Without miRNAs, the cortical size is significantly reduced due to decreased prolife-ration and increased cell death of neural stem cells and neural progenitors. Moreover, we have identified specific miRNAs that control proliferation of cortical progenitors. In addition, we have found that miRNAs are also important in determining specific motor neuron cell fate in developing spinal cord. These studies have provided tools for further gene therapy by manipulating miRNA expression in neural stem cells for the treatment of spinal cord injuries. In summary, our goals are to reveal molecular mechanisms that regulate normal development of the central nervous system, identify genetic causes of human neurological diseases, and develop new diagnostic and therapeutic approaches for human mental and neurodegeneration disorders.
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