Time: September 21, 2011
Place: Conference room of the Institute of Neuroscience
Fifth floor of Building 401
Soochow University
199 Ren-Ai Road, Suzhou City
Organizers: Xingshun Xu (Institute of Neuroscience, Soochow University)
Xiao-Jiang Li (Human Genetics, Emory University)
Symposium (Wednesday, September 21, 2011)
8:00-8:15 Tour in the Institute of Neuroscience
8:15-8:20 Welcome remarks by Dr. Xingshun Xu
8:20-8:30 Introduction of the Institute of Neuroscience by Dr. Guangyin Xu
Section one (15 min talk and 5 min discussion)
8:30－8:50 Guojun Bu, Ph.D.
Department of Neuroscience
Mayo Clinic, USA
Topic: Wnt signaling receptor LRP6 and Alzheimer's disease
8:50－9:10 Bruce Lamb Ph.D.
Department of Neurosciences, Lerner Research Institute
Cleveland Clinic, USA
Topic: Identification of Genetic Modifiers of Amyloid Deposition
9:10－9:30 Wim Annaert Ph.D.
Department of Molecular and Developmental Genetics
VIB, Belgium
Topic: Exploring presenilin function in endosomal trafficking using an omics approach
9:30－9:50 Quan-Hong Ma
Institute of Neuroscience
Soochow University, China
Topic: A DNA vaccine encoding myelin-related proteins in therapy of Alzheimer's disease
9:50－10:10 Break
Section two (15 min talk and 5 min discussion)
10:10－10:30 Steven Estus Ph.D.
Sanders-Brown Center On Aging
University of Kentucky, USA
Topic: Genetics of APOE Receptors in Alzheimer’s disease
10:30-10:50 Jian Cheng Ph.D.
Institute of Neuroscience
Soochow University, China
Topic: PTEN inhibition as a novel therapeutic approach for stroke
10:50-11:10 Ming Guo, M.D., Ph.D.
Brain Research Institute
David Geffen School of Medicine, UCLA, USA
Topic: Identifying new genes involved in Alzheimer's disease using Drosophila as a model.
11:10-11:30 Xingshun Xu M.D., Ph.D.
Institute of Neuroscience
Soochow University, China
Topic: Ahi1 conditional knockout causes depression-like behaviors in mice
11:30-11:50 Shihua Li M.D.
Department of Human Genetics
Emory University School of Medicine, USA
Topic: A mouse model of spinocerebellar ataxia type 17
12:00 Lunch
Speakers in
Guangyin Xu M.D., Ph.D.
Institute of
Soochow University
Topic: Introduction of the
Research field: the cellular and molecular mechanisms of chronic pain including visceral pain.
Guojun Bu, Ph.D.
Department of Neuroscience
Mayo
Topic: Wnt signaling receptor LRP6 and Alzheimer's disease
Research field: Cell biology of Alzheimer's disease (AD). He investigates the roles of low-density lipoprotein receptor (LDLR) family and their ligands in the central nervous system and in the pathogenesis of AD.
Bruce Lamb Ph.D.
Department of Neurosciences, Lerner Research Institute
Topic: Identification of Genetic Modifiers of Amyloid Deposition
Research field: The primary focus of Dr. Lamb's laboratory is to utilize transgenic mice to study the molecular basis of complex human genetic diseases. More specifically, we have developed genetic models of Alzheimer’s disease by introducing different human genes carrying Alzheimer’s disease-causing mutations into mice.
Wim Annaert Ph.D.
VIB Department of Molecular and Developmental Genetics
K.U.Leuven,
Topic: Exploring presenilin function in endosomal trafficking using an omics approach
Research field: Our laboratory is focused on understanding the molecular biology of membrane transport in a disease-related context covering Alzheimer’s disease and congenital disorders of glycosylation type II.
Quan-Hong Ma Ph.D.
Institute of Neuroscience
Soochow University, China
Topic: A DNA vaccine encoding myelin-related proteins in therapy of Alzheimer's disease
Research field: Dr. Ma focuses on identification of novel targets of Alzheimer’s Disease.
Steven Estus Ph.D.
Topic: Genetics of APOE Receptors in Alzheimer’s disease
Research field: the focus of Dr. Estus’ laboratory uses molecular genetics to identify genetic variants or polymorphisms that increase the risk of Alzheimer’s disease (AD) and elucidate the molecular and cellular mechanisms underlying AD.
Jian Cheng Ph.D.
Institute of
Soochow University
Topic: PTEN inhibition as a novel therapeutic approach for stroke
Research field: cellular and molecular mechanisms of Neural protection and Repair after stroke.
Ming Guo, M.D., Ph.D.
Brain Research Institute
David Geffen School of Medicine,
Topic: Identifying new genes involved in Alzheimer's disease using Drosophila as a model.
Research field: Dr. Guo’s Research interests focus on understanding mechanisms underlying neurodegenerative diseases including Alzheimer's disease (AD) and Parkinson's disease using Drosophila as a model system, and ultimately translating the findings to human studies.
Xingshun Xu M.D., Ph.D.
Institute of Neuroscience
Soochow University,
Topic: Ahi1 conditional knockout causes depression-like behaviors in mice
Research field: One of main projects focuses on the protective mechanisms of neuropeptides on hypoxia/ cerebral ischemia injury by using cell biology and molecular biology techniques. Another project is to investigate the functions of Ahi1 by using transgenic mice and the mechanisms of depression-like behaviors caused by Ahi1 deficiency.
Shihua Li M.D.
Department of Human Genetics
Emory University School of Medicine, USA
Topic: A mouse model of spinocerebellar ataxia type 17
Research field: Trinucleotide expansion and Neurodegenerative disease. Dr. Li utilizes molecular biology and transgenic mouse models to identify therapeutic targets for the treatment of HD and other polyglutamine diseases.
Xiao-Jiang Li M.D.
Department of
Research field: Dr. Li’s lab uses genetic manipulation of animal models, molecular and cell biological analysis of protein transport, and biochemical study of protein-protein interactions, to investigate the relationship between gene mutation and disease. phenotypes, explore mechanistic insight into the pathogenesis of neurodegeneration caused by polyQ expansion, and to help develop effective therapeutic strategies.