Introduction：

By integrating tools of materials, chemistry, biomolecular engineering, pharmaceutical science, and micro/nano fabrication, as well as understanding of the unique functions of natural materials, our research laboratory is interested in exploring functional polymeric and bioinspired materials for diverse biomedical applications, ranging from photoacoustic imaging, drug delivery, modulation of tumor microenvironment, regenerative medicine to immuno-engineering.

Specific projects:

- Polymeric nanoprobes for photoacoustic imaging
- Polymeric smart drug delivery systems for cancer therapy
- Engineering of biomimetic platforms and cell-based carriers for applications in cancer and other diseases
- Hydrogels for applications in cancer therapy and tissue engineering

Selected Papers:

[10] Jingjing Liu, Qian Chen, Liangzhu Feng and Zhuang Liu* Nanomedicine for Tumor Microenvironment Modulation and Cancer Treatment Enhancement Nano Today, DOI: 10.1016/j.nantod.2018.06.008
[9] Rui Zhang, Liangzhu Feng, Ziliang Dong, Li Wang, Chao Liang, Jiawen Chen, Qingxi Ma, Rui Zhang, Qian Chen, Yucai Wang, and Zhuang Liu*. “Glucose & oxygen exhausting liposomes for combined cancer starvation and hypoxia-activated therapy” Biomaterials, 162, 123-131(2018)
[8] Liangzhu Feng, Ziliang Dong, Danlei Tao, Yicheng Zhang, and Zhuang Liu*. “The Acidic Tumor Microenvironment: A Target for Smart Cancer Nano-theranostics” Natl. Sci. Rev., 5, 269–286 (2018)
[7] Guangbao Yang, Ligeng Xu, Yu Chao, Jun Xu, Xiaoqi Sun, Yifan Wu, Rui Peng, and Zhuang Liu*. “Hollow MnO2 as A Tumor-microenvironment-responsive Biodegradable Nano-platform for Combination Therapy Favoring Antitumor Immune Responses” Nat. Commun., 8, 902 (2017)
[6] Liangzhu Feng, Liang Cheng, Ziliang Dong, Danlei Tao, Todd E. Barnhart, Weibo Cai*, Meiwan Chen*, and Zhuang Liu*. “Theranostic Liposomes with Hypoxia-Activated Prodrug to Effectively Destruct Hypoxic Tumors Post-Photodynamic Therapy” ACS Nano, 11, 927-937 (2017)
[5] Xuejiao Song, Liangzhu Feng, Chao Liang, Min Gao, Guosheng Song, and Zhuang Liu*. “Liposomes Co-loaded with Metformin and Chlorin e6 Modulate Tumor Hypoxia during Enhanced Photodynamic Therapy” Nano Res., 1-13 (2016)
[4] Xuejiao Song, Liangzhu Feng, Chao Liang, Kai Yang, and Zhuang Liu*. “Ultrasound Triggered Tumor Oxygenation with Oxygen-Shuttle Nanoperfluorocarbon to Overcome Hypoxia-Associated Resistance in Cancer Therapies” Nano Lett., 16, 6145–6153(2016)
[3] Guosheng Song, Chao Liang, Xuan Yi, Qi Zhao, Liang Cheng, Kai Yang, and Zhuang Liu*., “Perfluorocarbon Loaded Hollow Bi2Se3 Nanoparticles for Timely Supply of Oxygen under Near-Infrared Light to Enhance Radiotherapy of Cancer” Adv. Mater., 28, 2716–2723 (2016)
[2] Wenwen Zhu, Ziliang Dong, Tingting Fu, Jingjing Liu, Qian Chen, Yonggang Li, Ran Zhu*, Ligeng Xu*, and Zhuang Liu*. “Modulation of Hypoxia in Solid Tumor Microenvironment with MnO2 Nanoparticles to Enhance Photodynamic Therapy” Adv. Funct. Mater., 26, 5490–5498 (2016)
[1] Hua Gong, Yu Chao, Jian Xiang, Xiao Han, Guosheng Song, Liangzhu Feng, Jingjing Liu, Guangbao Yang, Qian Chen, and Zhuang Liu*. “Hyaluronidase To Enhance Nanoparticle-Based Photodynamic Tumor Therapy” Nano Lett., 16, 2512–2521 (2016)