Introduction:

Inorganic nanomaterials with many unique physical and chemical properties have found interesting applications in biomedicine. In our laboratory, we have explored a wide range of inorganic nanomaterials, including carbon nanomaterials, rare-earth-based upconversion nanoparticles, 2D metal sulfide nanostructures, mesoporous nanomaterials and biomineralized nanostructures, for applications in multimodal bio-imaging and cancer theranostics.

Specific projects:
- Inorganic multifunctional composite nanostructures for bio-sensing, bio-imaging, and cancer theranostics
- Biodegradable and renal-clearable nanomaterials for in vivo biomedical applications
- Nano-enzymes for biomedical imaging and cancer therapy
- Biomineralized materials for drug delivery and immunoengineering

Selected Papers：

[10] Ziliang Dong, Liangzhu Feng*, Yu Hao, Muchao Chen, Min Gao, Yu Chao, He Zhao, Wenwen Zhu, Jingjing Liu, Chao Liang, Qiao Zhang, and Zhuang Liu*. “Synthesis of Hollow Biomineralized CaCO3–Polydopamine Nanoparticles for Multimodal Imaging-Guided Cancer Photodynamic Therapy with Reduced Skin Photosensitivity” J. Am. Chem. Soc., 140, 2165-2178(2018)
[9] Yuyan Chen, Liang Cheng*, Ziliang Dong, Yu Chao, Huali Lei, He Zhao, Jian Wang, and Zhuang Liu*. “Degradable Vanadium Disulfide Nanostructures with Unique Opticaland Magnetic Functions for Cancer Theranostics” Angew. Chem. Int. Ed., 56(42), 12991 (2017)
[8] Guosheng Song, Jiali Hao, Chao Liang, Teng Liu, Min Gao, Liang Cheng, Junqing Hu*, and Zhuang Liu*. “Degradable Molybdenum Oxide Nanosheets with Rapid Clearance and Efficient Tumor Homing Capabilities as A Novel Therapeutic Nano-platform” Angew. Chem. Int. Ed., 55, 2122–2126 (2016)
[7] Guosheng Song, Chao Liang, Hua Gong, Meifang Li, Xianchuang Zheng, Liang Cheng, Kai Yang*, Xiqun Jiang, and Zhuang Liu*. “Core-Shell MnSe@Bi2Se3 Fabricated via a Cation Exchange Method as Novel Nanotheranostics for Multimodal Imaging and Synergistic Thermo-radiotherapy” Adv. Mater., 27, 6110–6117(2015)
[6] Teng Liu, Chao Wang, Xing Gu, Hua Gong, Liang Cheng, Xiaoze Shi, Liangzhu Feng, Baoquan Sun, Zhuang Liu*. “Drug Delivery with PEGylated MoS2 Nano-sheets for Combined Photothermal and Chemotherapy of Cancer” Adv. Mater., 26, 3433–3440 (2014)
[5] Liang Cheng, Jingjing Liu, Xing Gu, Hua Gong, Xiaoze Shi, Teng Liu, Chao Wang, Xiaoyong Wang, Gang Liu, Huaiyong Xing, Wenbo Bu, Baoquan Sun, and Zhuang Liu*. “PEGylated WS2 Nanosheets as A Multifunctional Theranostic Agent for In Vivo Dual-modal CT / Photoacoustic Imaging Guided Photothermal Therapy” Adv. Mater., 26, 1886–1893, (2014)
[4] Xiaojing Wang, Chao Wang, Liang Cheng, Shuit-Tong Lee, and Zhuang Liu*. “Noble Metal Coated Single-walled Carbon Nanotubes for Applications in Surface Enhanced Raman Scattering Imaging and Photothermal Therapy” J. Am. Chem. Soc., 134, 7414–7422 (2012)
[3] Kai Yang, Lilei Hu, Xingxing Ma, Shuoqi Ye, Liang Cheng, Xiaoze Shi, Changhui Li, Yonggang Li, and Zhuang Liu*. “Multimodal Imaging Guided Photothermal Therapy using Functionalized Graphene Nano-sheets Anchored with Magnetic Nanoparticles” Adv. Mater., 24, 1868-1872 (2012)
[2] Liang Cheng, Kai Yang, Yonggang Li, Jianhua Chen, Chao Wang, Mingwang Shao*, Shuit-Tong Lee, and Zhuang Liu*. “Facile Preparation of Multifunctional Upconversion Nanoprobes for Multi-modal Imaging and Dual-targeted Photothermal Therapy” Angew. Chem. Int. Ed., 50, 7385-7390 (2011) 
[1] Kai Yang, Shuai Zhang, Guoxin Zhang, Xiaoming Sun, Shuit-Tong Lee and Zhuang Liu*. “Graphene in Mice: Ultra-high in vivo Tumor Uptake and Highly Efficient Photothermal Therapy” Nano Lett., 10, 3318–3323 (2010) (Highlighted by Nature)