无机纳米材料与肿瘤诊疗创新技术
方向介绍：
无机纳米材料具有一系列独特物理和化学性质，在生物医学成像与肿瘤治疗领域有着独特的潜在应用前景。本实验室发展了包括碳纳米材料、稀土发光纳米材料、二维金属硫化物纳米结构、无机介孔纳米材料、生物矿化纳米材料等在内的多种无机纳米材料，利用其光学、磁学、声学和X-射线吸收等物理性质，以及其pH响应、金属离子螯合、催化活性等化学性质，发展了多种多模态影像纳米探针和针对肿瘤的物理治疗与联合治疗策略。
主要研究方向：
- 无机复合功能纳米材料的构建及其在生物检测、影像与肿瘤诊疗中的应用；
- 可代谢无机纳米材料合成及其生物医学应用；
- 无机纳米酶探针的构建及其应用；
- 生物矿化无机生物材料的设计构建及其生物医学应用。
代表性论文：
[10] Ziliang Dong, Liangzhu Feng*, Yu Hao, Muchao Chen, Min Gao, Yu Chao, He Zhao, Wenwen Zhu, Jingjing Liu, Chao Liang, Qiao Zhang, and Zhuang Liu*. “Synthesis of Hollow Biomineralized CaCO3–Polydopamine Nanoparticles for Multimodal Imaging-Guided Cancer Photodynamic Therapy with Reduced Skin Photosensitivity” J. Am. Chem. Soc., 140, 2165-2178(2018)
[9] Yuyan Chen, Liang Cheng*, Ziliang Dong, Yu Chao, Huali Lei, He Zhao, Jian Wang, and Zhuang Liu*. “Degradable Vanadium Disulfide Nanostructures with Unique Opticaland Magnetic Functions for Cancer Theranostics” Angew. Chem. Int. Ed., 56(42), 12991 (2017)
[8] Guosheng Song, Jiali Hao, Chao Liang, Teng Liu, Min Gao, Liang Cheng, Junqing Hu*, and Zhuang Liu*. “Degradable Molybdenum Oxide Nanosheets with Rapid Clearance and Efficient Tumor Homing Capabilities as A Novel Therapeutic Nano-platform” Angew. Chem. Int. Ed., 55, 2122–2126 (2016)
[7] Guosheng Song, Chao Liang, Hua Gong, Meifang Li, Xianchuang Zheng, Liang Cheng, Kai Yang*, Xiqun Jiang, and Zhuang Liu*. “Core-Shell MnSe@Bi2Se3 Fabricated via a Cation Exchange Method as Novel Nanotheranostics for Multimodal Imaging and Synergistic Thermo-radiotherapy” Adv. Mater., 27, 6110–6117(2015)
[6] Teng Liu, Chao Wang, Xing Gu, Hua Gong, Liang Cheng, Xiaoze Shi, Liangzhu Feng, Baoquan Sun, Zhuang Liu*. “Drug Delivery with PEGylated MoS2 Nano-sheets for Combined Photothermal and Chemotherapy of Cancer” Adv. Mater., 26, 3433–3440 (2014)
[5] Liang Cheng, Jingjing Liu, Xing Gu, Hua Gong, Xiaoze Shi, Teng Liu, Chao Wang, Xiaoyong Wang, Gang Liu, Huaiyong Xing, Wenbo Bu, Baoquan Sun, and Zhuang Liu*. “PEGylated WS2 Nanosheets as A Multifunctional Theranostic Agent for In Vivo Dual-modal CT / Photoacoustic Imaging Guided Photothermal Therapy” Adv. Mater., 26, 1886–1893, (2014)
[4] Xiaojing Wang, Chao Wang, Liang Cheng, Shuit-Tong Lee, and Zhuang Liu*. “Noble Metal Coated Single-walled Carbon Nanotubes for Applications in Surface Enhanced Raman Scattering Imaging and Photothermal Therapy” J. Am. Chem. Soc., 134, 7414–7422 (2012)
[3] Kai Yang, Lilei Hu, Xingxing Ma, Shuoqi Ye, Liang Cheng, Xiaoze Shi, Changhui Li, Yonggang Li, and Zhuang Liu*. “Multimodal Imaging Guided Photothermal Therapy using Functionalized Graphene Nano-sheets Anchored with Magnetic Nanoparticles” Adv. Mater., 24, 1868-1872 (2012)
[2] Liang Cheng, Kai Yang, Yonggang Li, Jianhua Chen, Chao Wang, Mingwang Shao*, Shuit-Tong Lee, and Zhuang Liu*. “Facile Preparation of Multifunctional Upconversion Nanoprobes for Multi-modal Imaging and Dual-targeted Photothermal Therapy” Angew. Chem. Int. Ed., 50, 7385-7390 (2011)
[1] Kai Yang, Shuai Zhang, Guoxin Zhang, Xiaoming Sun, Shuit-Tong Lee and Zhuang Liu*. “Graphene in Mice: Ultra-high in vivo Tumor Uptake and Highly Efficient Photothermal Therapy” Nano Lett., 10, 3318–3323 (2010) (Highlighted by Nature)
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