生物材料与肿瘤微环境调控
方向介绍：
肿瘤微环境对于肿瘤的生长、转移与免疫逃逸等行为密切相关，肿瘤弱酸、乏氧、免疫抑制等微环境特征也是导致临床肿瘤治疗耐受的一个重要原因。本实验室发展了多种基于纳米技术与生物材料的肿瘤微环境调控策略，发现通过调控肿瘤微环境如逆转肿瘤乏氧状态，可有效提高肿瘤对于多种治疗策略的响应，在避免额外副作用的同时显著提高现有治疗策略（如放疗、化疗、光动力治疗、免疫治疗）的疗效。
主要研究方向：
- 碳酸钙基纳米复合物的可控制备与肿瘤微酸环境调控；
- 含氟生物材料在肿瘤乏氧微环境调节与治疗增效中的应用探索；
- 生物活性成分（酶、纳米酶等）的可控递送及在肿瘤微环境调控与治疗增效中的应用探索。
代表性论文：
[10] Jingjing Liu, Qian Chen, Liangzhu Feng and Zhuang Liu* Nanomedicine for Tumor Microenvironment Modulation and Cancer Treatment Enhancement Nano Today, DOI: 10.1016/j.nantod.2018.06.008
[9] Rui Zhang, Liangzhu Feng, Ziliang Dong, Li Wang, Chao Liang, Jiawen Chen, Qingxi Ma, Rui Zhang, Qian Chen, Yucai Wang, and Zhuang Liu*. “Glucose & oxygen exhausting liposomes for combined cancer starvation and hypoxia-activated therapy” Biomaterials, 162, 123-131(2018)
[8] Liangzhu Feng, Ziliang Dong, Danlei Tao, Yicheng Zhang, and Zhuang Liu*. “The Acidic Tumor Microenvironment: A Target for Smart Cancer Nano-theranostics” Natl. Sci. Rev., 5, 269–286 (2018)
[7] Guangbao Yang, Ligeng Xu, Yu Chao, Jun Xu, Xiaoqi Sun, Yifan Wu, Rui Peng, and Zhuang Liu*. “Hollow MnO2 as A Tumor-microenvironment-responsive Biodegradable Nano-platform for Combination Therapy Favoring Antitumor Immune Responses” Nat. Commun., 8, 902 (2017)
[6] Liangzhu Feng, Liang Cheng, Ziliang Dong, Danlei Tao, Todd E. Barnhart, Weibo Cai*, Meiwan Chen*, and Zhuang Liu*. “Theranostic Liposomes with Hypoxia-Activated Prodrug to Effectively Destruct Hypoxic Tumors Post-Photodynamic Therapy” ACS Nano, 11, 927-937 (2017)
[5] Xuejiao Song, Liangzhu Feng, Chao Liang, Min Gao, Guosheng Song, and Zhuang Liu*. “Liposomes Co-loaded with Metformin and Chlorin e6 Modulate Tumor Hypoxia during Enhanced Photodynamic Therapy” Nano Res., 1-13 (2016)
[4] Xuejiao Song, Liangzhu Feng, Chao Liang, Kai Yang, and Zhuang Liu*. “Ultrasound Triggered Tumor Oxygenation with Oxygen-Shuttle Nanoperfluorocarbon to Overcome Hypoxia-Associated Resistance in Cancer Therapies” Nano Lett., 16, 6145–6153(2016)
[3] Guosheng Song, Chao Liang, Xuan Yi, Qi Zhao, Liang Cheng, Kai Yang, and Zhuang Liu*., “Perfluorocarbon Loaded Hollow Bi2Se3 Nanoparticles for Timely Supply of Oxygen under Near-Infrared Light to Enhance Radiotherapy of Cancer” Adv. Mater., 28, 2716–2723 (2016)
[2] Wenwen Zhu, Ziliang Dong, Tingting Fu, Jingjing Liu, Qian Chen, Yonggang Li, Ran Zhu*, Ligeng Xu*, and Zhuang Liu*. “Modulation of Hypoxia in Solid Tumor Microenvironment with MnO2 Nanoparticles to Enhance Photodynamic Therapy” Adv. Funct. Mater., 26, 5490–5498 (2016)
[1] Hua Gong, Yu Chao, Jian Xiang, Xiao Han, Guosheng Song, Liangzhu Feng, Jingjing Liu, Guangbao Yang, Qian Chen, and Zhuang Liu*. “Hyaluronidase To Enhance Nanoparticle-Based Photodynamic Tumor Therapy” Nano Lett., 16, 2512–2521 (2016)
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