姓名：王明华

性别：男

出生年月：1975年9月

导师类别：博士生导师

技术职称：教授

所在学科专业

生物化学与分子生物学

主要研究方向

1.肿瘤分子遗传与分子诊断

2.肿瘤分子药理学

3.基因表达与调控

个人简历

1995.7大学毕业于西北大学生物系生物学专业，毕业后于陕西省教育学院生化系任教。

1997.9-2000.1于西北农林科技大学基础科学系攻读生物化学与分子生物学专业硕士学位，并获理学硕士。硕士学位论文工作在中国科学院北京微生物研究所遗传室完成。毕业后在上海第二医科大学上海市发育生物学重点实验室进修半年。

2001.9-2005.1于复旦大学遗传所攻读遗传学专业博士学位，并获理学博士。在遗传工程国家重点实验室从事博士学位论文工作。

2005.5月至今在18新利体育 基础医学与生物科学学院生物化学与分子生物系从事教学科研工作。2007年被聘为副教授。2019年被聘为教授。

2010.3－2012.2在美国约翰霍普金斯大学医学院高级访问研究。

教材编写

1. 2017.6《医学生物化学与分子生物学》  科学出版社,  主  编

2. 2017.7《生物化学与分子生物学》    科学出版社， 副主编

3. 2016.3《BIOCHEMISTRY》          科学出版社,  副主编

4. 2014.6《医学生物化学与分子生物学》  科学出版社， 副主编

5. 2016.7《生物化学》          中国医药科技出版社， 参  编

教学获奖

1. 2018年 指导学生获得第二届全国大学生生命竞赛三等奖

2. 2018年 指导学生获得18新利体育 第19届“挑战杯”大学生课外学       术科技作品竞赛一等奖

3. 2016年 获得18新利体育 交行教学奖

4. 2014年 获得18新利体育 第十三届青年教师课堂教学竞赛三等奖

主持项目

国家自然科学基金   （81872417）

国家自然科学基金   （81572923）

国家自然科学基金   （81071957）

国家自然科学基金   （30700826）

苏大医学发展基金   （EE134709）

苏州市科技计划项目  （SYS201419）

学术成果

  1. Zhao DM, Liu HG, Liu HC, Zhang XQ, Zhang M, Kolluri VK, Feng XL, He ZL, Wang MH, Zhu T, Yan X, Zhou YH. Downregulated expression of hsa_circ_0037515 and hsa_circ_0037516 as novel biomarkers for non-small cell lung cancer. AM J TRANSL RES 2020, 12(1): 162-170.

  2. Guo SC, Jiang S, Epperla N, Ma Y, Maadooliat M, Ye Z, Olson B, Wang MH, Kitchner T, Joyce J, An P, Wang F, Strenn R, Mazza JJ, Meece JK, Wu W, Jin L, Smith JA, Wang J, Schrodi SJ. A gene-based recessive diplotype exome scan discovers FGF6, a novel hepcidin-regulating iron-metabolism gene. BLOOD 2019, 133(17): 1888-1898.

  3. Jiang D, He ZL, Wang CJ, Zhou YH, Li F, Pu WL, Zhang XQ, Feng XL, Zhang M, Yecheng XY, Xu Y, Jin L, Guo SC, Wang JC, Wang MH. Epigenetic silencing of ZNF132 mediated by methylation-sensitive Sp1 binding promotes cancer progression in esophageal squamous cell carcinoma. CELL DEATH DIS 2018, 10(1): 1. (Corresponding author)

  4. Fan LX, He ZL, Head SA, Zhou YH, Lu T, Feng XL, Zhang XQ, Zhang M, Dang Y, Jiang X, Wang MH. Clofoctol and sorafenib inhibit prostate cancer growth via synergistic induction  of endoplasmic reticulum stress and UPR pathways. CANCER MANAG RES 2018, 10: 4817-4829. (Corresponding author)

  5. Wang CJ, Pu WL, Zhao DM, Zhou YH, Lu T, Chen S, He ZL, Feng XL, Wang Y, Li C, Li S, Jin L, Guo SC, Wang JC, Wang MH. Identification of Hyper-Methylated Tumor Suppressor Genes-Based Diagnostic Panel  for Esophageal Squamous Cell Carcinoma (ESCC) in a Chinese Han Population. FRONT GENET 2018, 9: 356. (Corresponding author)

  6. Pu WL, Wang CJ, Chen SD, Zhao DM, Zhou YH, Ma YJ, Wang Y, Li CH, Huang ZB, Jin L, Guo SC, Wang JC, Wang MH. Targeted bisulfite sequencing identified a panel of DNA methylation-based biomarkers for esophageal squamous cell carcinoma (ESCC).Clinical Epigenetics. 2017 Dec 15;9:129 eCollection. (Corresponding author)

  7. Fan LX, Chen LQ, Ni XL, Guo SC, Zhou YH, Wang CJ, Zheng YB, Shen FY, Kolluri V K, Muktiali M, Zhao ZH,Wu JJ, Zhao DM., He ZL., Feng XL, Yuan ZY, Zhang J, Jin L,Wang JC, Wang MH. Genetic variant of miR-4293 rs12220909 is associated with susceptibility to non-small cell lung cancer in a Chinese Han population. PLOS One.2017;12(4):e0175666.(Corresponding author)

  8. Shen FY, Chen JJ, Guo SC, Zhou YH, Zheng YB, Yang YJ, Zhang JJ, Wang XF. Wang CJ, Zhao DM, Wang MY, Zhu ML, Fan LX, Xiang JQ, Xia Y, Wei QY, Jin L, Wang JC, Wang MH. Genetic variants in miR-196a2 and miR-499 are associated with susceptibility to esophageal squamous cell carcinoma in Chinese Han population. Tumor Biol.2016 Apr;37(4):4777-4784(Corresponding author)

  9. Zhang P, Wang JJ, Lu T, Wang XF, Zheng YB, Guo SC, Yang YJ, Wang MY, Vijay Kumar Kolluri, Qiu LX, Shen FY, Fan LX, Li J, Wang YN, Wei,QY, Jin L, Wang JC, Wang MH. miR-449b rs10061133 and miR-4293 rs12220909 Polymorphisms are associated with decreased esophageal squamous cell carcinoma in a Chinese population. Tumor Biol.2015 112015.Nov;36(11):8789-8795(Corresponding author)

  10. Wang MH, Shim Joong Sup,Li Ruo-Jing, Dang YJ, He QQ,Das Manisha, Liu J, Identification of an old antibiotic clofoctol as a novel activator of unfolded protein response pathways and an inhibitor of prostate cancer. British Journal of Pharmacology. 2014.Oct,171(19):4478-4489

  11. Che JH , Dong J, Zheng YB, Zhu BP,Zhang P, Lu DY,Zhang JJ, Xiao JJ, Wang JG, Gao YZ, Yan XL, Wang MH. Polymorphism in PHD1 gene and risk of non-small cell lung cancer in a Chinese population. Tumor Biol. 2014 Sep;35(9):8921-8925. (Corresponding author)

  12. Xiao JJ, Zheng YB, Zhou YH, Zhang P, Wang JG, Shen FY, Fan LX, Vijay Kumar Kolluri, Wang WP, Yan XL, Wang MH. Sulfotransferase SULT1A1 Arg213His Polymorphism with Cancer Risk: A Meta-Analysis of 53 Case-Control Studies. PLOS ONE. 2014 Sep 16;9(9):e106774.(Corresponding author)  

  13. Lu DY, Mao XH, Zhou YH, Yan XL, Wang WP, Zheng YB, Xiao JJ, Zhang P, Wang JG, Neetika Ashwani, Ding WL, Jiang H, Shang Y, Wang MH. RTN4 3’-UTR Insertion/Deletion Polymorphism and Susceptibility to Non-Small Cell Lung Cancer in Chinese Han Population. Asian Pac J Cancer Prev.2014;15(13):5249-5252 (Corresponding author)  

  14. Zhang JJ, Huang XW, Xiao JJ, Yang YJ, Zhou YH, Wang XF, Liu QM, Yang JM, Wang MY, Qiu LX,Zheng YB, Zhang P, Li J, Wang YN, Wei QY, Jin L, Wang JC, Wang MH. Pri-miR-124 rs531564 and pri-miR-34b/c rs4938723 Polymorphisms Are Associated with Decreased Risk of Esophageal Squamous Cell Carcinoma in Chinese Populations. PLOS ONE.2014 Jun 19;9(6):e100055.(Corresponding author)  

  15. Wang MH, Wang WP, Zhang P, Xiao JJ, Wang JG, Huang CQ. Discrimination of the Expression of Paralogous microRNA Precursors That Share the Same Major Mature Form. PLOS ONE.2014 Mar 3;9(3):e90591.

  16. Zhang JJ, Zhou JS, Zhang P, Wang WP, Tao SH, Wang MH. A Meta-Analysis of the Association between the hOGG1 Ser326Cys Polymorphism and the Risk of Esophageal Squamous Cell Carcinoma. PLOS ONE.2013 Jun 6;8(6):e65742. (Corresponding author)

  17. Xu FQ, Wang WP, Lei C, Liu QM, Qiu H,Vinaydhar Muraleedharan, Zhou B, Cheng HX,Huang ZK, Xu WA,Li BC, Wang MH. Activation of transcriptional activity of HSE by a novel mouse zinc finger protein ZNFD specifically expressed in testis. Mol Cell Biochem.2012 Apr;363(1-2):409-17.(Corresponding author)

  18. Yang SR, Wang WP, Lei C, Liu QM, Xu FQ, Xing XW, Chen H, Liu JJ, Wu SL, Wang MH. Localization and characterization of rat transmembrane protein 225 specifically expressed in testis. DNA Cell Biol. 2011, 30: 9-16 (Corresponding author)

  19. Liu QM, Yao F, Wang MH, Zhou B, Cheng HX, Wang WP, Jin L, Lin Q, Wang JC. Novel human BTB/POZ domain-containing zinc finger protein ZBTB1 inhibits transcriptional activities of CRE. Mol Cell Biochem. 2011 Nov;357(1-2):405-14.  

  20. Lei C, Liu QM, Wang WP, Li J, Xu FQ, Liu YZ, Liu JJ, Wu SL, Wang MH. Isolation and characterization of a novel zinc finger gene, ZNFD, activating AP1(PMA) transcriptional activities. Mol Cell Biochem. 2010, 340: 63-71. (Corresponding author)

  21. .Wang JC, Wang MH, Zhang RM, Zhao ZM Chen J, Luo ZW. A chemiluminescence-based assessment of androgen binding activity in a large pedigree affected with androgen insensitivity syndrome,Luminescence.2007,22: 370–378

  22. Wang MH, Luo GM, Li F, Wu SL, Jiang JX, Huang CQ. Isolation and Characterization of a Novel Four-Transmembrane Protein PMP22CD Specifically Expressed in the Testis. Int. J. Mol. Sci. 2006,7, 425-437

  23. Wang MH, Wang JC, Zhang Z, Zhao ZM，Zhang RM, Hu XH, Tan T, Luo SJ, Luo ZW. Dissecting phenotypic variation among AIS patients. Biochem Biophys Res Commun. 2005,23;335(2):335-42.

  24. Zhang HT, Chen XF, Wang MH, Wang JC, Qi QY, Zhang RM, Xu WQ, Fei QY, Wang F, Cheng QQ, Chen F, Zhu CS, Tao SH, Luo Z. Defective expression of transforming growth factor beta receptor type II is associated with CpG methylated promoter in primary non-small cell lung cancer. Clin Cancer Res. 2004, 1;10(7):2359-67.

  25. Qi QY, Wang F, Zhang HT, Wang JC, Xiao HP, Wang MH, Han YF, Zhang RM, Tao SH, Luo ZW. Induced recovery of defective membrane expression of a CC chemokine receptor 5 mutant by phytohemagglutinin. Cell Mol Life Sci. 2003, 60(11):2492-500.

  26. Fei QY, Zhang HT, Chen XF, Wang JC, Zhang RM, Xu WQ, Zhang Z, Zou W, Zhang KY, QI QY, Wang MH, Tao sh, Luo Zw. Defected expression of E-cadherin in non-small cell lung cancer. Lung Cancer. 2002,37:147-152.

联系方式

电话：15695280329

EMAIL:mhwang@suda.edu.cn