报告题目：Reactive 3D Bioprinting ofStem Cells and Hydrogels for Soft Tissue Engineering

报告时间：2017年9月4日（周一）10：30

报告地点：18新利体育 南校区1号楼3楼骨科研究所317学术报告厅
报告人：Wenmiao (Will) Shu教授（英国斯特拉斯克莱德大学）

摘要：

Human pluripotent stem cells (hPSCs), including humanembryonic stem cells and human induced pluripotent stem cells, can bepotentially turned into any cell type in our body and self-renew indefinitelyto enable large populations of cells to be expanded in vitro. These uniquecharacteristics make pluripotent stem cells as one of the ideal cell sourcesfor use in a number of tissue engineering applications, from creating scalablehuman tissue models for novel drug discovery and drug toxicity testing toon-demand tissue/organ regeneration. One of the key challenges in 3Dbioprinting is to gently dispense or extrude highly viscious hydrogel materialswhile preventing the delicate biological cells from damages by shearstress.  This talk will give an overview of our efforts in 3D bioprintingof hPSCs including the development of a reactive 3D bioprinting techniques,printable novel hydrogel based bioinks and 3D stem cell differentiation. Although there are exciting early success in bioprinting of hPSCs and theirderived cells such as hepatocytes and cardiomyocytes, significant challengesand opportunities remain to be explored in the interface between 3Dbiofabrication, biomaterials and regenerative medicine to produce morerealistic hPSCs-derived human tissues for in-vitro models and transplantabletissues towards the ultimate aim of organ printing.

报告人简介：

Professor Wenmiao (Will) Shu is the Hay Professor inBiomedical Engineering at the University of Strathclyde (Glasgow). He obtainedhis PhD at the Engineering Department from University of Cambridge, UK. Hisresearch interests cover a range of biomedical engineering topics including 3Dbiofabrication, biosensors, microsystems and their applications forregenerative medicine. He led the research to demonstrate the first bioprintingof human embryonic stem cells (h-ESCs) and human induced pluripotent stem cells(h-iPSCs), paving the way for their applications on animal-free drug testingand 3D printed organs. He held a visiting position at Stanford University. Heis an editorial board member for IOP Biofabrication Journal and serves as aboard director of the International Society for Biofabrication (ISBF).