报告题目：Critical Role of Kindlin-2 in Skeletal Development and Homeostasis

报告时间：2017年3月22日（周三） 15：30

报告地点：18新利体育 南校区1号楼3楼骨科研究所317学术报告厅
报告人：肖国芝教授（南方科技大学）

摘要：

During the past 20 years, tremendous progress has been achieved in the field of basic research on bone biology, which in return greatly improves the treatment of osteoporosis, a major public health problem that affects millions of people worldwide. In this seminar,I will first review some important discoveries in basic bone biology research, including the identification of transcription factors (such as SOX9, RUNX2 and osterix) and major signals (including WNT signaling) critical for osteoblast/chondrocyte function and bone/cartilage development and homeostasis as well as the OPG-RANKL-RANK system and its role in regulation of osteoclast formation and bone resorption under physiological and pathological states. In the meantime, I will address the importance of basic bone biology research by discussing how these discoveries successfully led to development of state-of-the art therapeutics for osteoporosis and other bone-related diseases. I will finally share with you our recent study on the role of novel Kindlin-2 signaling in skeletal development and homeostasis and the implications of our findings for pathogenesis of bone-related diseases, such as osteoarthritis.

报告人简介：

Professor Guozhi Xiao is an internationally renowned bone biologist. Dr. Xiao obtained his PhD degree in biochemistry and molecular biology from Peking University in 1994. He did his post-doc training (1994-1998) and worked as a research scientist (1998-2005) at the University of Michigan Ann Arbor. In 2005, he assumed an independent faculty position as a tenure-track assistant professor at the University of Pittsburgh School of Medicine and was promoted to the level of associate professor with tenure in 2011. In 2012, he joined Rush University Medical Center in Chicago and assumed a prominent academic position as the Dr. Ralph and Marian C. Falk Endowed Chair Professor of Biochemistry and served as the director of research of the department of biochemistry. In 2013, he joined the SUSTech as a tenured full professor and later became the chair of the biological department. Dr. Xiao has made several contributions to our understanding the molecular control of skeletal development and homeostasis. His work is reported in more than 100 peer-reviewed publications, many in high profile journals such as the Journal of Clinical Investigation and Nature Communications. He serves as a reviewer for the US National Science Foundation, the Italian Ministry of Health and the National Natural Science Foundation of China and sits on the editorial boards of the Journal of Bone and Mineral Research (JBMR) and the Journal of Biological Chemistry (JBC). Dr. Xiao’s research interests focus in the following areas: (1) To determine how osteoblast, osteoclast, and chondrocyte formation is controlled during skeletal development and homeostasis under physiological and pathological conditions. (2) To define the mechanisms that modulate bone angiogenesis. (3) To study the bone-muscle interactions. By working on these projects, Xiao laboratory has also maintained a focus on important medical issues involving bone – osteoporosis, osteoarthritis, metastatic osteolytic lesions, and fracture healing. Information obtained from these studies will enhance our understanding of these pathological processes.