曾剑峰 特聘教授，博士生导师
电子邮箱：jfzeng@suda.edu.cn
通讯地址：苏州工业园区仁爱路199号, 邮编215123
办公电话：0512-65882542
个人简历
曾剑峰，18新利体育 放射医学与防护学院特聘教授。2008年本科毕业于中南大学化学工程与工艺专业，同年加入中国科学院化学研究所高明远研究员课题组硕博连读。2014年获得物理化学理学博士学位，毕业后进入18新利体育 分子影像与核医学研究中心。2016年获苏州市高等院校、科研院所紧缺高层次人才，2017年获18新利体育 优秀青年学者，2019年起任日本国立放射线医学综合研究所的客座研究员、中国医药生物技术协会造影技术分会委员。截至目前，主持国家级项目3项、省部级项目4项，在Adv. Mater.、J. Am. Chem. Soc.、Angew. Chem.Int. Ed.、ACS Nano、Biomaterials等学术刊物上发表学术论文50多篇，被引4000余次，申请发明专利10项。获教育部高等学校18新利备用网站 优秀成果奖（科学技术）一等奖（排名第五）及苏州市医学会医学科学技术一等奖（排名第四）。
学习经历：
2004-2008年 中南大学 化学工程与工艺专业本科
2008-2014年 中国科学院化学研究所 物理化学专业博士（导师：高明远）
研究方向：
w 分子影像与纳米医学
w 核医学药物
w 转化医学
科研项目：
1. 国家自然科学基金面上项目，82172003，易损性动脉粥样硬化斑块的早期预警及动态可视化评估，2022.01-2025.12，主持
2. 国家重点研发计划“数字诊疗装备”重点专项课题，2016YFC0101201，高灵敏肿瘤多模态纳米分子影像探针，2016.07-2018.12，主持
3. 国家重点研发计划“纳米科技”重点专项，2018YFA0208800，新型纳米氧化铁磁共振造影剂的宏量制备及临床转化研究，2018.05-2023.04，参与（项目PI）
4. 国家自然科学基金青年科学基金项目，21503141，高灵敏度化学交换饱和转移磁共振分子影像探针的构建及应用，2016.01-2018.12，主持
5. 江苏省高等学校自然18新利备用网站 重大项目，20KJA150006，磁共振/核医学双模态纳米分子影像探针应用基础研究，2020.10-2023.09，主持
6. 江苏省自然科学基金面上项目，BK20191418，可肾代谢氧化铁纳米磁共振造影剂的设计、合成及应用，2019.07-2022.06，主持
7. 苏州市重点产业技术创新项目，新型纳米氧化铁静脉补铁剂开发，2020.07-2023.06，主持
8. 中国博士后科学基金第9批特别资助，2016T90489，配位聚合物纳米颗粒诊疗一体化探针的构建及应用，2016.07-2018.06，15万元，主持
9. 中国博士后科学基金第57批面上资助（一等），2015M570472，高灵敏度智能化磁共振分子影像探针的构建及应用，2015.07-2017.06，主持
10. 北京分子科学国家实验室开放课题，20140165，高灵敏度智能化磁共振分子影像探针，2015.01-2016.12，主持
代表性论文：
1. Anchoring Group Mediated Radiolabeling of Inorganic Nanoparticles - A Universal Method for Constructing Nuclear Medicine Imaging Nanoprobes
Jianxian Ge, Lei Chen, Baoxing Huang, Yun Gao, Dandan Zhou, Yi Zhou, Can Chen, Ling Wen, Qing Li, Jianfeng Zeng*, Zhiyuan Zhong, and Mingyuan Gao*
ACS Appl. Mater. Inter.,2022,DOI: 10.1021/acsami.1c23907.
2. Anchoring Group Mediated Radiolabeling for Achieving Robust Nano-Imaging Probes
Lei Chen, Jianxian Ge, Baoxing Huang, Dandan Zhou, Gang Huang, Jianfeng Zeng*, and Mingyuan Gao
Small, 2021, 202104977
3. Ultrasmall Superparamagnetic Iron Oxide Nanoparticles: A Next Generation Contrast Agent for Magnetic Resonance Imaging
Can Chen#, Jianxian Ge#, Yun Gao, Lei Chen, Jiabin Cui, Jianfeng Zeng*, and Mingyuan Gao*
WIREs Nanomed. Nanobi., 2021. DOI: 10.1002/wnan.1740
4. Quantitative Mapping of Glutathione within Intracranial Tumors through Interlocked MRI Signals of a Responsive Nanoprobe
Peisen Zhang#, Jianfeng Zeng#, Yingying Li, Chen Yang, Junli Meng, Yi Hou,* and Mingyuan Gao*
Angew. Chem. Int. Edit., 2021, 60(15), 8130-8138.
5. Cell-Derived Biomimetic 2D Nanoparticles to Improve CellSpecific Targeting and Tissue Penetration for Enhanced Magnetic Resonance Imaging
Qianyi Zhang#, Dandan Zhou#, Guocheng Fang, Hongxu Lu, Jianfeng Zeng*, and Zi Gu*
Adv. Mater. Interfaces, 2021, 202101914.
6. A Pretargeting Strategy Enabled by Bioorthogonal Reactions Towards Advanced Nuclear Medicines: Application and Perspective
Yun Gao, Lei Chen, Jianxian Ge, Jiabin Cui, Jianfeng Zeng*, and Mingyuan Gao*
Chem. Res. Chinese U., 2021, 37(4), 870-879.
7. Recent Advances in Renal Clearable Inorganic Nanoparticles for Cancer Diagnosis
Ruiqi Yin, Xiaochen Zhang, Jianxian Ge, Ling Wen,* Lei Chen, Jianfeng Zeng,* Zhen Li, and Mingyuan Gao
Part. Part. Syst. Char., 2021,38(1), 2000270.
8. Radiolabeling nanomaterials for multimodality imaging: New insights into nuclear medicine and cancer diagnosis
Jianxian Ge, Qianyi Zhang, Jianfeng Zeng*, Zi Gu*, Mingyuan Gao
Biomaterials, 2020, 228, 119553.
9. Self-Assembled Hybrid Nanocomposites for Multimodal Imaging-Guided Photothermal Therapy of Lymph Node Metastasis
Wu Cai#, Guohua Fan#, Hui Zhou#, Lei Chen, Jianxian Ge, Baoxing Huang, Dandan Zhou, Jianfeng Zeng,* Qingqing Miao,* and Chunhong Hu*
ACS Appl. Mater. Inter., 2020, 12(44), 49407-49415.
10. Biodegradable Inorganic Nanoparticles for Cancer Theranostics: Insights into the Degradation Behavior
Hui Zhou#, Jianxian Ge#, Qingqing Miao, Ran Zhu, Ling Wen, Jianfeng Zeng*, and Mingyuan Gao
Bioconjugate Chem., 2020, 31, 2, 315-331.
11. A Dual-Modal Molecular Probe for Near-Infrared Fluorescence and Photoacoustic Imaging of Peroxynitrite
Jianjian Zhang, Xu Zhen, Jianfeng Zeng*, and Kanyi Pu*
Anal. Chem., 2018, 90(15), 9301-9307.
12. Dual-Ratiometric Target-Triggered Fluorescent Probe for Simultaneous Quantitative Visualization of Tumor Microenvironment Protease Activity and pH in vivo
Tiancong Ma#, Yi Hou#, Jianfeng Zeng#, Chunyan Liu, Peisen Zhang, Lihong Jing, Dihua Shangguan, and Mingyuan Gao*
J. Am. Chem. Soc., 2018, 140(1), 211-218.
13. Enhancing Both Biodegradability and Efficacy of Semiconducting Polymer Nanoparticles for Photoacoustic Imaging and Photothermal Therapy
Yan Lyu#, Jianfeng Zeng#, Yuyan Jiang, Xu Zhen, Ting Wang, Shanshan Qiu, Xin Lou*, Mingyuan Gao, Kanyi Pu*
ACS Nano, 2018, 12(2), 1801-1810.
14. Biodegradable Nano-agents with Short Biological Half-life for SPECT/PAI/MRI Multimodality Imaging and PTT Therapy of Tumors
Lei Chen#, Jaiyao Chen#, Shanshan Qiu, Ling Wen, Yan Wu, Yi Hou, Yong Wang, Jianfeng Zeng*, Yuan Feng, Zhen Li, Hong Shan*, and Mingyuan Gao*
Small, 2018, 14(4), 1702700.
15. Detection of Lymph Node Metastasis with Near-infrared Upconversion Luminescent Nanoprobes
Shanshan Qiu#, Jianfeng Zeng#, Yi Hou, Lei Chen, Jianxian Ge, Ling Wen, Chunyan Liu, Youjiu Zhang, Ran Zhu*, and Mingyuan Gao*
Nanosacle, 2018, 10(46), 21772-21781.
16. pH-Responsive Fe(III)-Gallic-Acid Nanoparticles for In-Vivo Photoacoustic Imaging Guided Photothermal Therapy
Jianfeng Zeng#, Ming Cheng#, Yong Wang, Ling Wen, Ling Chen, Zhen Li*, Yongyou Wu*, Mingyuan Gao*, Zhifang Chai
Adv. Healthc. Mater., 2016, 5(7), 772-780.
17. A Self-Assembled Albumin-Based Nanoprobe for In Vivo Ratiometric Photoacoustic pH Imaging
Qian Chen, Xiaodong Liu, Jiawen Chen, Jianfeng Zeng*, Zhenping Cheng, Zhuang Liu*
Adv. Mater., 2015, 27(43), 6820–6827.
18. Anchoring Group Effects of Surface Ligand on Magnetic Properties of Fe3O4 Nanoparticles: Towards High Performance MRI Contrast Agents
Jianfeng Zeng, Lihong Jing, Yi Hou, Mingxia Jiao, Ruirui Qiao, Qiaojuan Jia, Chunyan Liu, Fang Fang, Hao Lei, Mingyuan Gao*
Adv. Mater., 2014, 26(17), 2694-2698.
19. In Situ 111In-doping for Achieving Biocompatible and Non-leachable 111In-labeled Fe3O4 Nanoparticles
Jianfeng Zeng, Bing Jia, Ruirui Qiao, Chao Wang, Lihong Jing, Fan Wang Mingyuan Gao*
Chem. Commun., 2014, 50(17), 2170-2172.