1. Anna Wang, Jing Fang, Yali Feng, Yuqi Zhang, Yan Zhao, Jiachen Li, Chaoxiang Cui, Yi Hou, Haibin Shi*, Mingyuan Gao*, MMP-2 and upconverted UV dual-mediated drug sequential delivery and on-site immobilization for enhanced multidrug-resistant cancer therapy, Sci. China Chem., 2023, 66, 2317-2328.
2. Zhuorun Song, Jia Miao, Minqian Miao, Baoliang Cheng, Shenhua Li, Yinghua Liu, Qingqing Miao, QingLi*, MingyuanGao*, Cathepsin K-Activated Probe for Fluoro-Photoacoustic Imaging of Early Osteolytic Metastasis, Adv. Sci., 2023, 10, 202300217.
3. Dandan Zhou, Yun Gao, Zhe Yang, Ning Wang, Jianxian Ge, Xiaoyi Cao, Dandan Kou, Yuan Gu, Cang Li, Mohammad Javad Afshari, Ruru Zhang, Can Chen, Ling Wen*, Shuwang Wu, Jianfeng Zeng*, Mingyuan Gao, Biomimetic Upconversion Nanoplatform Synergizes Photodynamic Therapy and Enhanced Radiotherapy against Tumor Metastasis, ACS Appl. Mater. Interfaces, 2023, 15, 26431-26441.
4. Hui Zhou, Yuan Zhang, Ruru Zhang, Min Zhao, Wan Chen, Yinghua Liu, YueJiang, Qing Li, Qingqing Miao*, Mingyuan Gao*, A Tumor Microenvironment-Activatable Molecular Pro-theranostic Agent for Photodynamic and Immunotherapy of Cancer, Adv. Mater., 2023, 35, 2211485.
5. Yi Zhou#, Yun Gao#, Guangxin Duan, Ling Wen*, Shanshan Shan, Shuwang Wu*, Jianfeng Zeng, Mingyuan Gao*, Radioactive Microspheres for Selective Internal Radiation Therapy of Hepatocellular Carcinoma, Adv. NanoBiomed Res., 2023, 3(6), 2200166.
6. Ruixue Duan#*, Yueping Li#, Ruru Zhang, Xuelan Hu, Yi wang, Jianfeng Zeng*, Mingyuan Gao*, Reversing Acute Kidney Injury Through Coordinated Interplay of Anti-inflammation and Iron Supplementation, Adv. Mater., 2023, 35, 2301283.
7. Mohammad Javad Afshari#, Xiaju Cheng#, Guangxin Duan, Ruixue Duan, Shuwang Wu, Jianfeng Zeng, Zi Gu, and Mingyuan Gao*, Vision for Ratiometric Nanoprobes: In Vivo Noninvasive Visualization and Readout of Physiological Hallmarks, ACS Nano, 2023, 17(8), 7109-7134.
8. Dandan Kou, Yun Gao, Cang Li, Dandan Zhou, Kuan Lu, Ning Wang, Ruru Zhang, Zhe Yang, Yi Zhou, Lei Chen, Jianxian Ge, Jianfeng Zeng*, Mingyuan Gao*, Intranasal Pathway for Nanoparticles to Enter the Central Nervous System, Nano Lett., 2023, 23(11), 5381-5390.
9. Yangyun Wang#, Yanxian Wu#, Liubing Li#, Chunjie Ma, Shaodian Zhang, Subin Lin, Leshuai W. Zhang, Yong Wang*, Mingyuan Gao*, Chemotherapy-Sensitized In Situ Vaccination for Malignant Osteosarcoma Enabled by Bioinspired Calcium Phosphonate Nanoagents, ACS Nano, 2023, 17(7), 6247-6260.
10. Yuan Gu#, Subin Lin#, Yanxian Wu, Pei Xu, Wen Zhu, Yangyun Wang, Xiaju Cheng, Leshuai W Zhang, Roland H Stauber, Yong Wang*, Mingyuan Gao*, Targeting STING Activation by Antigen‐inspired MnO2 Nanovaccines Optimizes Tumor Radiotherapy, Adv. Healthcare Mater., 2023, 12(12), 2300028.
11. Manran Wu#, Lei Zhang#, Kexin Shi#, Dongxu Zhao, Weipeng Yong, Lingling Yin, Ruizhe Huang, Guanglin Wang*, Gang Huang, Mingyuan Gao*, Polydopamine-Coated Radiolabeled Microspheres for Combinatorial Radioembolization and Photothermal Cancer Therapy, ACS Appl. Mater. Interfaces, 2023, 15(10), 12669-12677.
12. Xiaojun Wei, Haoran Ning, Xiaodan Huang, Collin F Perkinson, Chunyan Liu, Zhuoyao Dong, Lihong Jing*, Mingyuan Gao*, Molten Salt Synthesis of Persistent Luminescent/Magnetic Cr3+-Doped Zinc Gallogermanate Particles, J. Phys. Chem. C, 2023, 127(7), 3733-3741.
13. Peisen Zhang#, Yicheng Feng#, Lichong Zhu, Kunyao Xu, Qiuhong Ouyang, Jianfeng Zeng, Feng Qin, Ni Zhang, Yuqing Wang, Fangfei He, Yufang Shi, Gang Chen, Zhe Shi, Meng Qin*, Yi Hou*, Mingyuan Gao*, Predicting Thrombolytic Haemorrhage Risk of Acute Ischemic Stroke Through Angiogenesis/Inflammation Dual-targeted MR Imaging, Nano Today, 2023, 48, 101707.
14. Lei Chen#, Yun Gao#, Jianxian Ge, Yi Zhou, Zhe Yang, Cang Li, Baoxing Huang, Kuan Lu, Dandan Kou, Dandan Zhou, Can Chen, Sixia Wang, Shuwang Wu, Jianfeng Zeng*, Gang Huang, Mingyuan Gao*, A Clinically Translatable Kit for MRI/NMI Dual-Modality Nanoprobes Based on Anchoring Group-Mediated Radiolabeling, Nanoscale, 2023, 15, 3991-3999.
15. Shuyue Ye, Yali Feng, Yuqi Zhang, Jing Fang, Anna Wang, Chaoxiang Cui, Jinfeng Zhu, Liangsheng Guo, Guohua Fan*, Haibin Shi*, Furin Enzyme-Responsive siRNA Delivery System for Efficient Anti-Hypoxia Assisted Cancer Photodynamic Therapy, CCS Chem., 2023, DOI: 10.31635/ccschem.023.202302777.
16. Huawei Xia, Jinfeng Zhu, Changhe Men, Anna Wang, Qiulian Mao, Yali Feng, Jiachen Li, Jingwei Xu, Xiaju Cheng*, Haibin Shi*, Light-initiated Aggregation of Gold Nanoparticles for Synergistic Chemo-Photothermal Tumor Therapy. Nanoscale Adv., 2023, 5, 3053-3062.
19. Xiedong Hong, LangTian, Qiong Wu, Liming Gu, Wenli Wang, Hanxu Wu, Mingxiao Zhao, Xiaojin Wu, Chang Wang*, Plasma metabolomic signatures from patients following high-dose total body irradiation. Mol. Omics., 2023, 19, 492-503.
20. Yuan Gu, Subin Lin, Yanxian Wu, Pei Xu, Wen Zhu, Yangyun Wang, Xiaju Cheng, Leshuai W. Zhang, Roland H. Stauber, Yong Wang*, Mingyuan Gao*, Targeting STING Activation by Antigen-Inspired MnO2 Nanovaccines Optimizes Tumor Radiotherapy. Adv. Healthcare Mater. 2023, 2300028.
21. Shanshan Shan#*, Yang Gao#, Paul Z.Y. Liu, Brendan Whelan, Hongfu Sun, Bin Dong, Feng Liu, David E.J. Waddington, Magnetic Resonance in Medicine., 2023, 1-15.
22. Yangyun Wang, Yanxian Wu, Liubing Li, Chunjie Ma, Shaodian Zhang, Subin Lin, Leshuai W. Zhang, Yong Wang*, Mingyuan Gao*, Chemotherapy-Sensitized In Situ Vaccination for Malignant Osteosarcoma Enabled by Bioinspired Calcium Phosphonate Nanoagents. ACS Nano 2023, 17 (7), 6247-6260.
1. Yuping Xu#, Peisen Zhang#, Shuming Jin#, Chuang Liu, Lin Yang, Zhuo Ao, Meng Qin, Kaili Nie, Yi Hou*, Mingyuan Gao*, Tracking How Biodegraded Microplastics Enter the Ecosystem with CuInS2@ZnS QDs, J. Phys. Chem. C, 2022, 126(48), 20605-20612.
2. Lei Yang, Mohammad Javad Afshari, Jianxian Ge, Dandan Kou, Lei Chen, Dandan Zhou, Cang Li, Shuwang Wu, Leshuai Zhang, Jianfeng Zeng*, Jian Zhong, Roland H Stauber, Mingyuan Gao*, Functionalized Ultrasmall Iron Oxide Nanoparticles for T1-Weighted Magnetic Resonance Imaging of Tumor Hypoxia, Molecules, 2022, 27(20), 6929.
3. Mohammad Javad Afshari, Cang Li, Jianfeng Zeng, Jiabin Cui, Shuwang Wu, Mingyuan Gao*, Self-illuminating NIR-II Bioluminescence Imaging Probe Aased on Silver Sulfide Quantum Dots, ACS Nano, 2022, 16(10), 16824-16832.
4. Jianxian Ge, Cang Li, Ning Wang, Ruru Zhang, Mohammad Javad Afshari, Can Chen, Dandan Kou, Dandan Zhou, Ling Wen*, Jianfeng Zeng*, Mingyuan Gao, Effects of PEG Chain Length on Relaxometric Properties of Iron Oxide Nanoparticles-Based MRI Contrast Agent, Nanomaterials, 2022, 12(15), 2673.
5. Yinghua Liu#, Jianfeng Zeng#, Qing Li*, Minqian Miao, Zhuorun Song, Min Zhao, Qingqing Miao*, and Mingyuan Gao*, An APN-activated Chemiluminescent Probe for Image-guided Surgery of Malignant Tumors, Adv. Opt. Mater., 2022, 2102709.
6. Yangyun Wang#, Subin Lin#, Hanqiu Jiang, Yuan Gu, Yanxian Wu, Jie Ma, Yubin Ke, Leshuai W. Zhang, Yong Wang*, Mingyuan Gao*, Visualizable Delivery of Nanodisc Antigen-Conjugated Adjuvant for Cancer Immunotherapy, CCS Chemistry, 2022, 4, 1238-1250.
7. Wan Chen, Yuan Zhang, Qing Li*, Yue Jiang, Hui Zhou, Yinghua Liu, Qingqing Miao*, and Mingyuan Gao*, Near-Infrared Afterglow Luminescence of Chlorin Nanoparticles for Ultrasensitive In Vivo Imaging, J. Am. Chem. Soc., 2022, 144, 6719-6726.
8. Junli Meng#, Peisen Zhang#, Qizhe Chen, Zihua Wang, Yuan Gu, Jie Ma, Wang Li, Chen Yang, Yuanyuan Qiao, Yi Hou, Lihong Jing, Yong Wang, Zi Gu, Lichong Zhu, Haozhen Xu, Xueguang Lu*, Mingyuan Gao*, Two-pronged Intracellular Co-delivery of Antigen and Adjuvant for Synergistic Cancer Immunotherapy, Adv. Mater., 2022, 2202168.
9. Guangxin Duan#, Ling Wen#, Xingwei Sun, Zhuxin Wei, Ruixue Duan, Jiangfeng Zeng, Jiabin Cui, Chunyi Liu, Zepeng Yu, Xiaofang Xie, Mingyuan Gao*, Healing Diabetic Ulcers with MoO3-X Nanodots Possessing Intrinsic ROS‐Scavenging and Bacteria‐Killing Capacities, Small, 2022, 18(10), 2107137.
10. Jianxian Ge, Lei Chen, Baoxing Huang, Yun Gao, Dandan Zhou, Yi Zhou, Can Chen, Ling Wen, Qing Li, Jianfeng Zeng*, Zhiyuan Zhong, and Mingyuan Gao*, Anchoring Group-Mediated Radiolabeling of Inorganic Nanoparticles─ A Universal Method for Constructing Nuclear Medicine Imaging Nanoprobes, ACS Appl. Mater. Interfaces, 2022, 14(7), 8838-8846.
11. Manran Wu, Kexin Shi, Ruizhe Huang, Chunyi Liu, Lingling Yin, Weipeng Yong, Jing Sun, Guanglin Wang*, Zhiyuan Zhong, Mingyuan Gao*, Facile Preparation of 177Lu-microspheres for Hepatocellular Carcinoma Radioisotope Therapy, Chinese Chem. Lett., 2022, 33(7), 3492-3496.
12. Zhilin Jiang, Bin Xia, Feng Ren, Bolin Bao, Wei Xing, Tao He, and Zhen Li*, Boosting Vascular Imaging-Performance and Systemic Biosafety of Ultra-Small NaGdF4 Nanoparticles via Surface Engineering with Rationally Designed Novel Hydrophilic Block Co-Polymer. Small Methods, 2022. 6,3, e2101145.
13. Tingting Wang, Hao Zhang, Weibao Qiu, Yaobao Han, Hanghang Liu, and Zhen Li*, Biomimetic nanoparticles directly remodel immunosuppressive microenvironment for boosting glioblastoma immunotherapy. Bioact. Mater., 2022. 16, 418-432.
14. Qi Xu, Hao Zhang, Hanghang Liu, Yaobao Han, Weibao Qiu, and Zhen Li*, Inhibiting autophagy flux and DNA repair of tumor cells to boost radiotherapy of orthotopic glioblastoma. Biomaterials, 2022. 280, 121287.
15. Jiaxin Yuan, Hanghang Liu, Hao Zhang, Tinging Wang, Qing Zheng, and Zhen Li*, Controlled Activation of TRPV1 Channels on Microglia to Boost Their Autophagy for Clearance of Alpha-Synuclein and Enhance Therapy of Parkinson's Disease. Adv. Mater., 2022. 34,11, e2108435.
16. Hao Zhang, Tingting Wang, Hanghang Liu, Yaobao Han, Qing Zheng, Qi Xu, Bolin Bao, Wei Xing, and Zhen Li*, Boost therapy of hepatocellular carcinoma by amplifying vicious cycle between mitochondrial oxidative stress and endoplasmic reticulum stress via biodegradable ultrasmall nanoparticles and old drug. Nano Today, 2022. 46, 101601.
17. Hongqin Zhu, Feng Ren, Tingting Wang, Zhilin Jiang, Qiao Sun*, and Zhen Li*, Targeted Immunoimaging of Tumor-Associated Macrophages in Orthotopic Glioblastoma by the NIR-IIb Nanoprobes. Small, 2022. 18, 30, e2202201.
18. Hanghang Liu, Qing Zheng, Jiaxin Yuan, Yifan Gao, Tingting Wang, Hao Zhang, and Zhen Li*, Modulating SQSTM1/p62-dependent selective autophagy of neurons by activating Nrf2 with multifunctional nanoparticles to eliminate α-synuclein aggregates and boost therapy of Parkinson’s disease. Nano Today, 2023. 49, 101770.
19. Tingting Wang, Hao Zhang, Yaobao Han, Qing Zheng, Hanghang Liu, Mengxiao Han, and Zhen Li*, Reversing T Cell Dysfunction to Boost Glioblastoma Immunotherapy by Paroxetine-Mediated GRK2 Inhibition and Blockade of Multiple Checkpoints through Biomimetic Nanoparticles. Adv. Sci., 2023, e2204961.
20. Qing Zheng, Hanghang Liu, Hao Zhang, Yaobao Han, Jiaxin Yuan, Tingting Wang, Yifan Gao, and Zhen Li*, Ameliorating Mitochondrial Dysfunction of Neurons by Biomimetic Targeting Nanoparticles Mediated Mitochondrial Biogenesis to Boost the Therapy of Parkinson's Disease. Adv. Sci., 2023, e2300758.
23. Yuqi Zhang, Jing Fang, Shuyue Ye, Yan Zhao, Anna Wang, Qiulian Mao, Chaoxiang Cui, Yali Feng, Jiachen Li, Sunao Li, Mingyang Zhang, and Haibin Shi*, A Hydrogen Sulphide-responsive and Depleting Nanoplatform for Cancer Photodynamic Therapy, Nature Commun, 2022, 13, 1685.
24. Jing Fang, Yan Zhao, Anna Wang, Yuqi Zhang, Chaoxiang Cui, Shuyue Ye, Qiulian Mao, Yali Feng, Jiachen Li, Chenjie Xu, and Haibin Shi*, In Vivo Quantitative Assessment of Radiation Dose Based on Ratiometric Photoacoustic Imaging of Tumor Apoptosis, Anal. Chem., 2022, 94, 5149-5158.
25. Chaoxiang Cui, Jiachen Li, Jing Fang, Yan Zhao, Yuqi Zhang, Shuyue Ye, Anna Wang, Yali Feng, Qiulian Mao, Hongni Qin, and Haibin Shi*, Building multipurpose nano-toolkit by rationally decorating NIR-II fluorophore to meet the needs of tumor diagnosis and treatment, Chinese Chem. Lett., 2022, 33, 3478-3483.
26. Huan Yu, Haoxiang Guo, He Zu, Heng Ding, Subin Lin, Yangyun Wang, Leshuai W. Zhang*, Yong Wang*, Therapeutic dendritic cell vaccines engineered with antigen-biomineralized Bi2S3 nanoparticles for personalized tumor radioimmunotherapy. Aggregate 2022, 3 (5), e194.
27. Ya-Nan Xia, He Zu, Haoxiang Guo, Tianyan Jiang, Siqi Yang, Huan Yu, Shaodian Zhang, Heng Ding, Xiaoyu Li, Yangyun Wang, Yong Wang*, Leshuai W. Zhang*, Preclinical safety and hepatotoxicity evaluation of biomineralized copper sulfide nanoagents. Journal of Nanobiotechnology 2022, 20 (1), 185.
28. Ruoling Gao, Yuan Gu, Ying Yang, Yuping He, Wenpeng Huang, Ting Sun, Zaixiang Tang, Yong Wang*, Wei Yang*, Robust radiosensitization of hemoglobin-curcumin nanoparticles suppresses hypoxic hepatocellular carcinoma. Journal of Nanobiotechnology 2022, 20 (1), 115.
29. Chen TG, Zhang XQ, Ge JF, Xu YJ*, Sun R*. Thiocarbonyl photosensitizer, a feasible way to eliminate the photosensitizer residues in photodynamic therapy. Spectrochim Acta A Mol Biomol Spectrosc. 2022, 270:120783
30. Qing Yu , Gang Zhang , Ya-Nan Wang , Hao-Chi Hao , Ru Sun , Yu-Jie Xu,* , JianFeng Ge* Fluorescence enhancement of near infrared cell membrane probe by β-cyclodextrin supramolecular interaction. Dyes and Pigments 2022,207,110693
1. Real-time Visualization of Embryonic Apoptosis Using A Near-Infrared Fluorogenic Probe for Embryo Development Evaluation.
Lei He, Shuyue Ye, Jing Fang, Yuqi Zhang, Chaoxiang Cui, Anna Wang, Yan Zhao, Haibin Shi.*
Anal Chem. 2021, in press.
2. Quantitatively visualizing the activity of MMP-2 enzyme in vivo using a ratiometric photoacoustic probe.
Ling Yin, Anna Wang, Haibin Shi,* and Mingyuan Gao.*
Methods in Enzymology, 2021, DOI: 10.1016/bs.mie.2021.06.035.
3. Furin Enzyme and pH Synergistically Triggered Aggregation of Gold Nanoparticles for Activated Photoacoustic Imaging and Pho-tothermal Therapy of Tumors.
Xiaju Cheng,≠ Xiuxia Zhou,≠ Jingwei Xu,≠ Rui Sun, Huawei Xia, Jianan Ding, Y. Eugene Chin, Zhifang Chai, Haibin Shi,* and Mingyuan Gao.*
Anal Chem. 2021, 93(26), 9277-9285.
4. Smart On-site Immobilizable NIR-II Fluorescent Nanoprobes for Ultra Long-term Imaging-guided Tumor Surgery and Photothermal Therapy.
Yuqi Zhang, Meng Zhao, Jing Fang, Shuyue Ye, Anna Wang, Yan Zhao, Chaoxiang Cui, Lei He, Haibin Shi*.
ACS Appl. Mater. Interf. 2021, 13, 12857-12865.
5. Sequential SPECT and NIR-II imaging of tumor and sentinel lymph node metastasis for diagnosis and image-guided surgery.
Xiaolu Zhang, Meng Zhao, Ling Wen, Manran Wu, Yi Yang, Yujuan Zhang, Yan Wu, Jian Zhong,* Haibin Shi, Jianfeng Zeng, Guanglin Wang*, Mingyuan Gao*.
Biomaterials Sci.2021, 9(8), 3069-3075.
6. A novel humanized Frizzled-7-targeting antibody enhances antitumor effects of Bevacizumab against triple-negative breast cancer via blocking Wnt/β-catenin signaling pathway.
Wei Xie*, Huijie Zhao, Fengxian Wang, Yiyun Wang, Yuan He, Tong Wang, Kunchi Zhang, Hao Yang, Zhaoli Zhou, Haibin Shi, Jin Wang, Gang Huang.*
Journal of Experimental & Clinical Cancer Research. 2021, 40(30), DOI: 10.1186/s13046-020-01800-x.
7. Ferritin-Engineered Nanoprobes for Tumor Targeted Trip-NIR Imaging and Phototherapy
Yuan Gu,Yang Zhou, Yanxian Wu, Jie Ma, Yangyun Wang, Qi Wang,*Yong Wang*
Analytical Chemistry, 2021, 93, 8835-8845.
8. Iodinated BSA Nanoparticles for CT Imaging and Repair of Gastritis
Yanxian Wu,Jun Gu,Shaodian Zhang,Yuan Gu, Jie Ma, Yangyun Wang,*Leshuai W. Zhang,Yong Wang* Analytical Chemistry, 2021, 92(3), 2128-2134.
9. Visualizable Delivery of Nanodisc Antigen-Conjugated Adjuvant for Cancer Immunotherapy
Yangyun Wang, Subin Lin, Hanqiu Jiang, Yuan Gu, Yanxian Wu, Jie Ma, Yubin Ke, Leshuai W. Zhang, Yong Wang,* Mingyuan Gao*
CCS Chemistry, 2021, 3, 1328-1340.
10. NIR-II Fluorescence Imaging for Cerebrovascular Diseases
Feng Ren, Zhilin Jiang, Mengxiao Han, Hao Zhang, Baofeng Yun, Hongqin Zhu, Zhen Li*
View, 2021, 20200128.
11. Implantable coaxial nanocomposite biofibers for local chemo-photothermal combinational cancer therapy
Hanghang Liu, Sepehr Talebian, Kara L. Vine, Zhen Li*, Javad Foroughi*
Nano Select, 2021, 1-15.
12. 智能化金纳米颗粒自组装及其生物医学应用进展。
朱明芮; 毛秋莲; 赵燕; 史海斌; 中国研究型医院，2021, 8(1), 12-22。
1.Radiolabeling nanomaterials for multimodality imaging: New insights into nuclear medicine and cancer diagnosis
Jianxian Ge, Qianyi Zhang, Jianfeng Zeng,* Zi Gu,* Mingyuan Gao
Biomaterials, 2020, 228, 119553.
2.Biodegradable Inorganic Nanoparticles for Cancer Theranostics: Insights into the Degradation Behavior
Hui Zhou,# Jianxian Ge,# Qingqing Miao, Ran Zhu, Ling Wen, Jianfeng Zeng,* and Mingyuan Gao
Bioconjugate Chem., 2020, 31, 2, 315-331.
3. Bone-Seeking Albumin-Nanomedicine for In Vivo Imaging and Therapeutic Monitoring
Zhizhong Chen, Wei Lu, Junkang Shen,* Yong Wang, Yangyun Wang*
ACS Biomaterials Science & Engineering, 2020, 6, 647-653.
4. NIR Nanoprobe Facilitated Cross-Referencing Manifestation of Local Disease Biology for Dynamic Therapeutic Response Assessment
Zhimin Wang, Xiangzhao Ai, Zhijun Zhang, Yong Wang, Xiangyang Wu, Richard Haindl, Edwin K.L. Yeow, Wolfgang Drexler, Mingyuan Gao, Bengang Xing*
Chemical Science, 2020, 11, 803-811.
5. An Activatable Polymeric Reporter for Near-Infrared Fluorescent and Photoacoustic Imaging of Invasive Cancer
Qing Li#, Shenhua Li#, Shasha He, Wan Chen, Penghui Cheng, Yan Zhang, Qingqing Miao,* and Kanyi Pu*
Angew. Chem. Int. Ed., 2020, 59, 7018-7023 (Cover).
6. Boosting H2O2-Guided Chemodynamic Therapy of Cancer by Enhancing Reaction Kinetics through Versatile Biomimetic Fenton Nanocatalysts and the Second Near-Infrared Light Irradiation
Tingting Wang, Hao Zhang, Hanghang Liu, Qiang Yuan, Feng Ren, Yaobao Han, Qiao Sun, Zhen Li,* Mingyuan Gao
Adv. Funct. Mater., 2020, 30, 1906128.
7. Overcoming Radioresistance in Tumor Therapy by Alleviating Hypoxia and Using HIF-1 Inhibitor
Xingguo Zhou, Hanghang Liu, Yanhui Zheng, Yaobao Han, Tingting Wang, Hao Zhang, Qiao Sun, Zhen Li*
ACS Appl. Mater. Interfaces, 2020, 12, 4231-4240.
8. Size-Dependent Photothermal Conversion and Photoluminescence of Theranostic NaNdF4 Nanoparticles under Excitation of Different-Wavelength Lasers
Lihua Ding, Feng Ren, Zheng Liu, Zhilin Jiang, Baofeng Yun, Qiao Sun, Zhen Li*
Bioconjugate Chem., 2020, 31, 340-351.
9. The Second Near-Infrared Window Persistent Luminescence for Anti-Counterfeiting Application
Changqiu Ma, Hanghang Liu, Feng Ren, Zheng Liu, Qiao Sun, Chongjun Zhao,* Zhen Li*
Cryst. Growth Des., 2020, 20, 1859-1867.
10. Synthesis, Modification and Bioapplications of Nanoscale Copper Chalcogenides
Baofeng Yun, Hongqin Zhu, Jiaxin Yuan, Qiao Sun, Zhen Li*
J. Mater. Chem. B, 2020, accepted.
11. Engineering NIR-IIb Fluorescence of Er-Based Lanthanide Nanoparticles for Through-skull Targeted Imaging and Imaging-guided Surgery of Orthotopic Glioma
Feng Ren, Hanghang Liu, Hao Zhang, Zhilin Jiang, Bin Xia, Cécile Genevois, Tao He, Mathieu Allix, Qiao Sun, Zhen Li,* Mingyuan Gao
Nano Today, 2020, accepted.
12. Sulfenic Acid-Mediated On-site-specific Immobilization of Mitochondrial-Targeted NIR Fluorescent Probe for Prolonged Tumor Imaging
Yinjia Gao, Rui Sun, Meng Zhao, Jianan Ding, Anna Wang, Shuyue Ye, Yuqi Zhang, Qiulian Mao, Wei Xie, Guolin Ma, and Haibin Shi*
Anal Chem. 2020, 92(10), 6977-6983.
13. A Novel αvβ3 Integrin-Targeted NIR-II Nanoprobe for Multimodal Imaging-guided Photothermal Therapy of Tumor In Vivo
Meng Zhao, Jianan Ding, Qiulian Mao, Yuqi Zhang, Yinjia Gao, Shuyue Ye, Hongni Qin, and Haibin Shi*
Nanoscale, 2020, 12(13), 6953-6958 (2020 Nanoscale HOT Article Collection).
14. Targeting Microglia for Therapy of Parkinson’s Disease by Using Biomimetic Ultrasmall Nanoparticles
Hanghang Liu, Yaobao Han, Tingting Wang, Hao Zhang, Qi Xu, Jiaxin Yuan, Zhen Li*
J. Am. Chem. Soc., 2020, 142(52), 21730-21742.
15. Copper-Chalcogenide-Based Multimodal Nanotheranostics
Hao Zhang, Xiaoqing Zeng, and Zhen Li*
ACS Appl. Bio Mater., 2020, 3(10), 6529–6537.
16. An improved pseudotargeted GC-MS/MS-based metabolomics method and its application in radiation-induced hepatic injury in a rat model
Hanxu Wu, Chao Xu, Yifeng Gu, ShugaoYang, Yarong Wang, Chang Wang*
J Chromatogr B Analyt Technol Biomed Life Sci. 2020,1152, 122250.
1. In Vivo Photoacoustic/Single-Photon Emission Computed Tomography Imaging for Dynamic Monitoring of Aggregation-Enhanced Photothermal Nanoagents
Yangyun Wang,Ziling Sun,Zhizhong Chen, Yanxian Wu, Yuan Gu, Subin Lin, Yong Wang*
Analytical Chemistry, 2019, 91(3), 2128-2134.
2. Multispectral Optoacoustic Imaging of Dynamic Redox Correlation and Pathophysiological Progression Utilizing Upconversion Nanoprobes
Xiangzhao Ai, Zhimin Wang, Haolun Cheong, Yong Wang, Ruochong Zhang, Jun Lin, Yuanjin Zheng, Mingyuan Gao,* Bengang Xing*
Nature Communications, 2019, 10, 1087.
3. Effective Radiotherapy in Tumor Assisted by Ganoderma lucidum Polysaccharide-Conjugated Bismuth Sulfide Nanoparticles through Radiosensitization and Dendritic Cell Activation
Huan Yu, Yang Yang, Tianyan Jiang, Xihui Zhang, Yuhao Zhao, Guibin Pang, Yahui Feng, Shulei Zhang, Fujun Wang, Yong Wang, Yangyun Wang,* Leshuai W. Zhang*
ACS Applied Materials & Interfaces, 2019, 11, 27536−27547.
4. Gold Nanorods and Graphene Oxide Enhanced BSA-AgInS2 Quantum Dots Based Photoelectrochemical Sensors for Detection of Dopamine
Yunxiao Li, Zhengping Li, Weixiang Ye, Shuang Zhao, Song Ma, Guohua Liu, Yong Wang, Zhao Yue*
Electrochimica Acta, 2019, 295, 1006-1016.
5. Self-Illuminating Agents for Deep-Tissue Optical Imaging
Qing Li, Jianfeng Zeng, Qingqing Miao* and Mingyuan Gao
Front. Bioeng. Biotechnol., 2019, 7, 326.
6. Early metabolic characterization of brain tissues after whole body radiation based on gas chromatography-mass spectrometry in a rat model
Xueting Yao, Chao Xu, Yurong Cao, Lin Lin, Hanxu Wu, Chang Wang*
Biomed Chromatogr., 2019, 33 (3), e4448.
7.Synthesis of azonia cyanine derivatives as NIR fluorescent probes for nucleic acid detection and cell imaging.
Yuan Chen, # Xue-Rui Wei, # Ru Sun, Yu-Jie Xu,* Jian-Jeng Ge*
Analytical methods, 2019, 11(28), 3523-3531.
8.Nanoagents Based on Poly(ethylene glycol)-b-poly(L-thyroxine) Block Copolypeptide for Enhanced Dual Modality Imaging and Targeted Tumor Radiotherapy
Xiaolei Gu, Zhehong Zhu, Qianyi Fan, Yaohua Wei, Guanglin Wang, Fenghua Meng, Zhiyuan Zhong,* and Chao Deng*
Small, 2019, 1902577.
9. Small, Traceable, Endosome-Disrupting and Bioresponsive Click Nanogels Fabricated via Microfluidics for CD44-Targeted Cytoplasmic Delivery of Therapeutic Proteins
Ke Huang, Yahui He, Zhehong Zhu, Jiakun Guo, Guanglin Wang, Chao Deng,* and Zhiyuan Zhong*
ACS Appl. Mater. Interfaces, 2019, 11, 22171-22180.
10. Iodine-rich Polymersomes Enable Versatile SPECT/CT Imaging and Potent Radioisotope Therapy for Tumor In Vivo
Jinsong Cao, Yaohua Wei, Yanxiang Zhang, Guanglin Wang,* Xiang Ji, and Zhiyuan Zhong*
ACS Appl. Mater. Interfaces, 2019, 11, 18953-18959.
11.Boosting the Radiosensitizing and Photothermal Performance of Cu2-xSe Nanocrystals for Synergetic Radiophotothermal Therapy of Orthotopic Breast Cancer
Qian Huang, Shaohua Zhang, Hao Zhang, Yaobao Han, Hanghang Liu, Feng Ren, Qiao Sun, Zhen Li,* Mingyuan Gao
ACS Nano, 2019, 13, 1342-1353.
12. Second Near-Infrared Photodynamic Therapy and Chemotherapy of Orthotopic Malignant glioblastoma with Ultra-small Cu2-xSe Nanoparticles
Hao Zhang, Tingting Wang, Hanghang Liu, Feng Ren, Weribao Qiu, Qiao Sun, Fei Yan, Hairong Zheng, Zhen Li,* Mingyuan Gao
Nanoscale, 2019, 11, 7600-7608.
13. Light-enhanced O2-evolving Nanoparticles Boost Photodynamic Therapy to Elicit Anti-tumor Immunity
Tingting Wang, Hao Zhang, Yaobao Han, Hanghang Liu, Feng Ren, Jianfeng Zeng, Qiao Sun, Zhen Li,* Mingyuan Gao
ACS Appl. Mater. Interfaces, 2019, 11, 16367-16379.
14. Cholesterol-Modified Black Phosphorus Nanospheres for the First NIR-II Fluorescence Bioimaging
Yifan Xu, Feng Ren, Hanghang Liu, Hao Zhang, Yaobao Han, Zheng Liu, Wenliang Wang, Qiao Sun, Chongjun Zhao,* Zhen Li*
ACS Appl. Mater. Interfaces, 2019, 11, 21399-21407.
15. The Release and Detection of Copper Ions from Ultrasmall Theranostic Cu2-xSe Nanoparticles
Yaobao Han, Tingting Wang, Hanghang Liu, Shaohua Zhang, Hao Zhang, Mengting Li, Qiao Sun, Zhen Li*
Nanoscale, 2019, 11, 11819-11829.
16. Boosting Often Overlooked Long Wavelength Emissions of Rare-Earth Nanoparticles for NIR-II Fluorescence Imaging of Orthotopic Brain Tumor
Zheng Liu, Feng Ren, Hao Zhang, Q. Yuan, Zhilin Jiang, Hanghang Liu, Qiao Sun, Zhen Li*
Biomaterials, 2019, 219, 119364.
17. Ultra-Sensitive Detection and Inhibition of the Metastasis of Breast Cancer Cells to Adjacent Lymph Nodes and Distant Organs by Using Long Persistent Luminescence Nanoparticles
Hanghang Liu, Feng Ren, Xingguo Zhou, Changqiu Ma, Tingting Wang, Hao Zhang, Qiao Sun,* Zhen Li*
Anal. Chem., 2019, 91, 15064-15072.
1. A Dual-Modal Molecular Probe for Near-Infrared Fluorescence and Photoacoustic Imaging of Peroxynitrite
Jianjian Zhang, Xu Zhen, Jianfeng Zeng,* and Kanyi Pu*
Anal. Chem., 2018, 90(15), 9301-9307.
2.Dual-Ratiometric Target-Triggered Fluorescent Probe for Simultaneous Quantitative Visualization of Tumor Microenvironment Protease Activity and pH in vivo
Tiancong Ma,# Yi Hou,# Jianfeng Zeng,# Chunyan Liu, Peisen Zhang, Lihong Jing, Dihua Shangguan, and Mingyuan Gao*
J. Am. Chem. Soc., 2018, 140(1), 211-218.
3.Enhancing Both Biodegradability and Efficacy of Semiconducting Polymer Nanoparticles for Photoacoustic Imaging and Photothermal Therapy
Yan Lyu,# Jianfeng Zeng,# Yuyan Jiang, Xu Zhen, Ting Wang, Shanshan Qiu, Xin Lou,* Mingyuan Gao, Kanyi Pu*
ACS Nano, 2018, 12(2), 1801-1810.
4.Biodegradable Nano-agents with Short Biological Half-life for SPECT/PAI/MRI Multimodality Imaging and PTT Therapy of Tumors
Lei Chen,# Jaiyao Chen,# Shanshan Qiu, Ling Wen, Yan Wu, Yi Hou, Yong Wang, Jianfeng Zeng,* Yuan Feng, Zhen Li, Hong Shan,* and Mingyuan Gao*
Small, 2018, 14(4), 1702700.
5.Detection of Lymph Node Metastasis with Near-infrared Upconversion Luminescent Nanoprobes
Shanshan Qiu,# Jianfeng Zeng,# Yi Hou, Lei Chen, Jianxian Ge, Ling Wen, Chunyan Liu, Youjiu Zhang, Ran Zhu,* and Mingyuan Gao*
Nanosacle, 2018, 10(46), 21772-21781.
6. Biomineralized Enzyme-Like Cobalt Sulfide Nanodots for SynergeticPhototherapy with Tumor Multimodal Imaging Navigation
Subin Lin, Yangyun Wang, Zhizhong Chen, Liubing Li, Jianfeng Zeng, Qirong Dong, Zhifang Chai, Yong Wang*
ACS Sustainable Chemistry & Engineering, 2018, 6(9), 12061–12069.
7. Noninvasive Multimodal Imaging of Osteosarcoma and Lymph Nodes Using a 99mTc-Labeled Biomineralization Nanoprobe
Zhiming Xu,Yangyun Wang,JianshanHan, Qingqing Xu,Jiawei Ren, Jiaying Xu, Yong Wang,*Zhifang Chai
Analytical Chemistry, 2018, 90, 4529–4534.
8. The Protective Role of Autophagy in Nephrotoxicity Induced by Bismuth Nanoparticles Through AMPK/mTOR Pathway
Yongming Liu, Huan Yu, Xihui Zhang, Yong Wang, Jian Zhao, Haibin Shi, Ruibin Li, Yangyun Wang,* Leshuai W. Zhang*
Nanotoxicology, 2018, 12, 586-601.
9. Sulfonyl-Containing Boronate Caps for Optimization of Biological Properties of 99mTc(III) Radiotracers [99mTcCl(CDO)(CDOH)2B-R] (CDOH2= Cyclohexanedione Dioxime)
Zuoquan Zhao, Min Liu, Wei Fang,* Shuang Liu*
J. Med. Chem., 2018, 61(1): 319-328.
10. Monitoring tyrosine kinase inhibitor therapeutic responses with a panel of metabolic biomarkers in chronic myeloid leukemia patients
Bingyu Yang, Chang Wang,* Yiyu Xie, Liangjing Xu, Xiaojin Wu, Depei Wu
Cancer Sci., 2018, 109(3), 777-784.
11.Prediction of acute GVHD and relapse by metabolic biomarkers after allogeneic hematopoietic stem cell transplantation
Xiaojin Wu , Yiyu Xie , Chang Wang,* Yue Han , Xiebing Bao , Shoubao Ma , Ahmet Yilmaz , Bingyu Yang , Yuhan Ji , Jinge Xu , Hong Liu , Suning Chen , Jianying Zhang , Jianhua Yu, Depei Wu
JCI Insight,2018, 3(9), pii: 99672.
12. Guangming Zhou. Long non-coding RNA CRYBG3 regulates glycolysis of lung cancer cells by interacting with lactate dehydrogenase A
Huaiyuan Chen, Hailong Pei, Wentao Hu, Ji Ma, Jian Zhang, Weidong Mao, Jing Nie, Chao Xu, Bingyan Li, Tom K. Hei, Chang Wang*
J. Cancer, 2018, 9(14), 2580-2588.
13.The improvement of lysosome targetability with oligoethyleneoxy chains linked benzo[a]phenoxazine
Wei-Jin Zhu, Jin-Yun Niu, Ru Sun, Yu-Jie Xu,* Jian-Feng Ge*
Bioorganic & Medicinal Chemistry Letters.2018, 28(15), 2953-295.
14.Construction of dual-functional polymer nanomaterials with near-infrared fluorescence imaging and polymer prodrug by RAFT mediated aqueous dispersion polymerization
Chun Tian, # Jinyun Niu,# Xuerui Wei, Yujie Xu,* Lifen Zhang,* Zhenping Cheng,* Xiulin Zhu.
Nanoscale, 2018, 10, 10277-10287.
15.Near-infrared pH probes based on phenoxazinium connecting with nitrophenyl and pyridinyl groups
Wei-Jin Zhu, # Jin-Yun Niu,# Dan-Dan He, Ru Sun, Yu-Jie Xu,* Jian-Feng Ge*
Dyes and Pigments, 2018, 149, 481-490.
16.The fluorescent biomarkers for lipid droplets with quinolone-coumarin unit
Yuan Chen, Xue-Rui Wei, Ru Sun,* Yu-Jie Xu,* Jian-Feng Ge*
Organic & Biomolecular Chemistry, 2018, 16(41), 7619-7625.
17. Highly Effective Radioisotope Cancer Therapy with a Non-therapeutic Isotope Delivered and Sensitized by Nanoscale Coordination Polymers
Yu Chao, Chao Liang, Yu Yang, Guanglin Wang, Debabrata Maiti, Longlong Tian, Fei Wang, Wei Pan, Song Wu,* Kai Yang,* and Zhuang Liu*
ACSNano,2018, 12(8), 75197528.
18. Photosensitizer-crosslinked in-situ Polymerization on Catalase for Tumor Hypoxia Modulation Enhanced Photodynamic Therapy
Hairong Wang, Yu Chao, Jingjing Liu, Wenwen Zhu, Guanglin Wang, Ligeng Xu, and Zhuang Liu*
Biomaterials, 2018, 181, 310-317.
19. Bottom-up Preparation of Uniform Ultrathin Rhenium Disulfide Nanosheets for Image-Guided Photothermal-Radiotherapy
Sida Shen, Yu Chao, Ziliang Dong, Guanglin Wang, Xuan Yi, Guosheng Song, Kai Yang, Zhuang Liu, and Liang Cheng*
Adv. Funct. Mater., 2017, 27, 170025.
20. Vacancy Engineering of Cu2-xSe Nanoparticles with Tunable LSPR and Magnetism for Dual-modal Imaging Guided Photothermal Therapy of Cancer
Shaohua Zhang, Qian Huang, Lijuan Zhang, Hao Zhang, Yaobao Han, Qiao Sun, Zhenxiang Cheng, Huizhu Qin, Shixue Dou, and Zhen Li*
Nanoscale, 2018, 10, 3130-3143.
21. Oral Administration of Highly Bright Cr3+ Doped ZnGa2O4 Nanocrystals for in vivo Targeted Imaging of Orthotopic Breast Cancer
Hanghang Liu, Feng Ren, Hao Zhang, Yaobao Han, Huizhu Qin, Jianfeng Zeng, Yong Wang, Qiao Sun, Zhen Li,* Mingyuan Gao
J. Mater. Chem. B, 2018, 6, 1508-1518.
22. Functionalization of Small Black Phosphorus Nanoparticles for Targeted Imaging and Photothermal Therapy of Cancer
Lijuan Deng, Yifan Xu, Caixia Sun, Baofeng Yun, Qiao Sun, Chongjun Zhao,* Zhen Li*
Sci. Bull., 2018, 63, 917-924.
23. Ultra-small Nanocluster Mediated Synthesis of Nd-doped Core-Shell Nanocrystals with Emission in the Second Near-Infrared Window for Multimodal Imaging of Tumor Vasculature
Feng Ren, Lihua Ding,Hanghang Liu, Qian Huang, Hao Zhang, Lijuan Zhang, Jianfeng Zeng, Qiao Sun, Zhen Li,* and Mingyuan Gao
Biomaterials, 2018, 175, 30-43.
24. Monitoring the Opening and Recovery of the Blood-Brain-Barrier with Non-invasive Molecular Imaging by Biodegradable Ultrasmall Cu2-xSe Nanoparticles
Hao Zhang, Tingting Wang, Weibao Qiu, Yaobao Han, Qiao Sun, Jianfeng Zeng, Fei Yan, Hairong Zheng, Zhen Li*
Nano Lett, 2018, 18, 4985-4992.
25. Blood circulation, Biodistribution and Pharmacokinetics of Dextran Modified Black Phosphorus Nanoparticles
Caixia Sun, Lijuan Deng, Yifan Xu, Hao Zhang, Qiao Sun, Chongjun Zhao,* Zhen Li*
ACS Appl.Bio. Mater., 2018, 1, 673-682.
26.Cu-Fe-Se Ternary Nanosheet-Based Drug Delivery Carrier for Multimodal Imaging and Combined Chemo-photothermal Therapy of Cancer
Xinxin Jiang, Yaobao Han, Hao Zhang, Hanghang Liu, Qian Huang, Tingting Wang, Qiao Sun, Zhen Li*
ACS Appl. Mater. Interfaces,2018, 10, 43396-43404.
1. Monodisperse Dual Plasmonic Au@Cu2-xE (E= S, Se) Core@Shell Supraparticles: Aqueous Fabrication, Multimodal Imaging, and Tumor Therapy at in Vivo Level
Hui Zhu,Yong Wang, Chao Chen, Mingrou Ma, Jianfeng Zeng, Shuzhou Li, Yunsheng Xia,* and Mingyuan Gao
ACS Nano, 2017, 11 (8), 8273–8281.
2. Size-Tunable Gd2O3@Albumin Nanoparticles Conjugating Chlorin e6 for Magnetic Resonance Imaging-Guided Photo-Induced Therapy
Lijuan Zhou, Junxing Wang, Tao Yang, Qiaoli Wang, Xiaoyan Lv, Hengte Ke, Zhengqing Guo, Junkang Shen, Yong Wang,* Chungen Xing,* Huabing Chen*
Theranostics, 2017,7(3), 764-774.
3.Photoelectrochemical Determination of Hydrogen Peroxide Using a Gold Electrode Modified with Fluorescent Gold Nanoclusters and Graphene Oxide
Shuang Zhao, Jun Zhang, Zhengping Li, Peixin Zhang, Yunxiao Li, Guohua Liu, Yong Wang,* Zhao Yue*
Microchimica Acta, 2017, 184(3), 677-686.
4. Autophagy associated cytotoxicity and cellular uptake mechanisms of bismuth nanoparticles in human kidney cells
Yongming Liu, Jing Zhuang, Xihui Zhang, Cong Yue, Ning Zhu, Liecheng Yang, Yong Wang, Tao Chen, Yangyun Wang,* Leshuai W. Zhang*
Toxicology Letters, 2017, 275, 39-48.
5. Novel Approach for 99mTc-Labeling of Red Blood Cells: Evaluation of 99mTc-4SAboroxime as a Blood Pool Imaging Agent
Min Liu, Zuoquan Zhao, Wei Fang,* Shuang Liu*
Bioconjug. Chem., 2017, 28(12): 2998-3006.
6.99mTc-3Cboroxime: a novel 99mTc(III) complex [99mTcCl(CDO)(CDOH)2B-3C] (CDOH2= cyclohexanedione dioxime; 3C-B(OH)2= 3-(carbamoylphenyl)boronic acid) with high heart uptake and long myocardial retention
Min Liu, Shuang Liu*
Dalt. Trans.,2017, 46(42): 14509-14518.
7.Urinary Metabolic Signatures and Early Triage of Acute Radiation Exposure in Rat Model
Mingxiao Zhao, Kim KT Lau, Xian Zhou, Jianfang Wu, Jun Yang, Chang Wang*
Mol. Biosyst.,2017, 13(4), 756-766.
8. An oxazine-based near-infrared fluorescent probefor selective in cellular imaging of exogenous nitrite
Yan-Hua Zhan, Ru Sun, Wei-Jin Zhu, Yu-Jie Xu,* Jian-Feng Ge*
Sensors &Actuators: B. Chemical, 2017, 240, 1283-1290.
9. Radionuclide I-131 Labeled Albumin-Paclitaxel Nanoparticles for Synergistic Combined Chemo-Radioisotope Therapy of Cancer
Longlong Tian, Qian Chen, Xuan Yi, Guanglin Wang, Jie Chen, Ping Ning, Kai Yang,* Zhuang Liu*
Theranostics, 2017, 7(3), 614-623.
10. Nanopolymersomes with an Ultrahigh Iodine Content for High Performance X-Ray Computed Tomography Imaging In Vivo Contrast Agent
Yan Zou, Yaohua Wei, Guanglin Wang, Fenghua Meng, Mingyuan Gao, Gert Storm and Zhiyuan Zhong*
Adv. Mater., 2017, 29, 1603997.
11. Whittaker, Molecular Imaging of Activated Platelets via Antibody-Targeted Ultra-small Iron Oxide Nanoparticles Displaying Unique Dual MRI Contras
Hang T. Ta,* Zhen Li,* Christoph E Hagemeyer, Gary Cowin, Shaohua Zhang, Jathushan Palasubramaniam, Karen Alt, Xiaowei Wang, N. Kurniawan, Karlheinz Peter, Andrew K Whittaker
Biomaterials, 2017, 134, 31-42.
12. Ultra-Small Magnetic CuFeSe2 Ternary Nanocrystals for Multimodal Imaging Guided Photothermal Therapy of Cancer
Xinxin Jiang, Shaohua Zhang, Feng Ren, Lei Chen, Jianfeng Zeng, Mo Zhu, Zhenxiang Cheng, Mingyuan Gao, Zhen Li*
ACS Nano, 2017, 11, 5633-5645.
