孟烜宇 - 18新利体育

孟烜宇，副教授，硕士生导师

学习及工作经历

2002-2006 吉林大学化学专业获学士学位

2006-2011 吉林大学物理化学专业获博士学位

2009-2011 美国弗吉尼亚联邦大学医学院联合培养博士生

2012-2014 美国弗吉尼亚联邦大学医学院研究员

2014-至今 18新利体育副教授

研究方向

孟烜宇主要从事生物大分子的计算机模拟研究，研究方向涉及离子通道等跨膜蛋白的作用机制、蛋白质相互作用、纳米药物与蛋白质的相互作用、药物小分子设计等。对离子通道等跨膜蛋白有深入研究。目前已发表英文学术书籍1章，SCI论文20余篇。其中钾通道论文以Feature Article发表在《Biophysical Journal》上，多篇文章发表在《Natural Chemical Biology》,《Proc. Natl. Acad. Sci.》,《Acs Nano》，《Science Advances》，《Scientific Reports》，《Carbon》，《Journal of Biological Chemistry》等杂志上。

科研项目

主持国家自然科学基金青年基金项目一项《PIP2诱导打开内向整流钾通道门控的分子机理的研究》。

代表性论文

1. Ma D, Meng X-Y*, Bell DR, Liu S, Zhou R*. Inhibition of CYP2C8 by metallofullerenol Gd@C82(OH)22 through blocking substrate channels and substrate recognition sites. Carbon. 2018;127(Supplement C):667-75.

2. Meng X-Y, Zhang H-X, Logothetis Diomedes E, Cui M. The Molecular Mechanism by which PIP2 Opens the Intracellular G-Loop Gate of a Kir3.1 Channel. Biophysical Journal. 2012;102(9):2049-59.

3. Meng X-Y, Li B, Liu S, Kang H, Zhao L, Zhou R. EGCG in Green Tea Induces Aggregation of HMGB1 Protein through Large Conformational Changes with Polarized Charge Redistribution. Scientific reports. 2016;6.

4. Meng X-Y, Liu S, Cui M, Zhou R, Logothetis DE. The Molecular Mechanism of Opening the Helix Bundle Crossing (HBC) Gate of a Kir Channel. Scientific Reports. 2016;6.

5. Zhang M, Meng X-Y, Zhang J-f, Cui M, Logothetis DE. Molecular overlap in the regulation of SK channels by small molecules and phosphoinositides. Science Advances. 2015;1(6).

6. Zhang M, Meng X-Y, Cui M, Pascal JM, Logothetis DE, Zhang J-F. Selective phosphorylation modulates the PIP2 sensitivity of the CaM–SK channel complex. Nature Chemical Biology. 2014;10(9):753-9.

7. Xu Y*, Wang Y*, Meng X-Y*, Zhang M, Jiang M, Cui M, Tseng G-N. Building KCNQ1/KCNE1 Channel Models and Probing their Interactions by Molecular-Dynamics Simulations. Biophysical Journal. 2013;105(11):2461-73.

8. Liu S*, Meng X-Y*, Perez-Aguilar JM, Zhou R. An In Silico study of TiO2 nanoparticles interaction with twenty standard amino acids in aqueous solution. Scientific Reports. 2016;6.

9. Meng X-Y, Zheng Q-C, Zhang H-X. A comparative analysis of binding sites between mouse CYP2C38 and CYP2C39 based on homology modeling, molecular dynamics simulation and docking studies. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 2009;1794(7):1066-72.

10. Meng X-Y, Zhang H-X, Mezei M, Cui M. Molecular Docking: A powerful approach for structure-based drug discovery. Current computer-aided drug design. 2011;7(2):146-57.

11. Meng X-Y, Xu Y, Zhang H-X, Mezei M, Cui M. Predicting Protein Interactions by Brownian Dynamics Simulations. Journal of Biomedicine and Biotechnology. 2012;2012:121034.

12. Meng X-Y, Mezei M, Cui M. Computational Approaches for Modeling GPCR Dimerization. Current pharmaceutical biotechnology. 2014;15(10):996-1006.

13. Meng X-Y, LZ, Niu Rui-juan, Zhang Hong-xing, Zheng Qing-chuan. Molecular Docking of 3-Methylindole-containing Drugs Binding into CYP3A4. Chemical Research in Chinese Universities. 2012;28:137-41.

14. Logothetis DE, Petrou VI, Zhang M, Mahajan R, Meng X-Y, Adney SK, Cui M, Baki L. Phosphoinositide Control of Membrane Protein Function: A Frontier Led by Studies on Ion Channels. Annual Review of Physiology. 2015;77(1):81-104.

15. Tang Q-Y, Zhang Z, Meng X-Y, Cui M, Logothetis DE. Structural Determinants of Phosphatidylinositol 4,5-Bisphosphate (PIP2) Regulation of BK Channel Activity through the RCK1 Ca2+ Coordination Site. Journal of Biological Chemistry. 2014;289(27):18860-72.

16. Rodriguez-Menchaca AA, Adney SK, Tang Q-Y, Meng X-Y, Rosenhouse-Dantsker A, Cui M, Logothetis DE. PIP2 controls voltage-sensor movement and pore opening of Kv channels through the S4–S5 linker. Proceedings of the National Academy of Sciences. 2012;109(36):E2399–E408.

17. Adney SK, Ha J, Meng X-Y, Kawano T, Logothetis DE. A Critical Gating Switch at a Modulatory Site in Neuronal Kir3 Channels. The Journal of Neuroscience. 2015;35(42):14397-405.

18. Liu B, Ha M, Meng X-Y, Khaleduzzaman M, Zhang Z, Li X, Cui M. Functional characterization of the heterodimeric sweet taste receptor T1R2 and T1R3 from a New World monkey species (squirrel monkey) and its response to sweet-tasting proteins. Biochemical and Biophysical Research Communications. 2012;427(2):431-7.

19. Liu B, Ha M, Meng X-Y, Kaur T, Khaleduzzaman M, Zhang Z, Jiang P, Li X, Cui M. Molecular Mechanism of Species-dependent Sweet Taste toward Artificial Sweeteners. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011;31(30):11070-6.

20. Zhou X, Meng X-Y, Li M-X, Pan Q-J, Zhang H-X. Theoretical Studies on the Spectroscopic Properties of N, N′-Bis (salicylidene)-1, 2-ethylenediaminePt (Ⅱ) Complexes [J]. Chemical Journal of Chinese Universities. 2008;6:039.

联系方式

E-mail：xymeng@suda.edu.cn

地址：18新利体育独墅湖校区401号楼1300室