Title： | Non-invasive transdermal delivery of biomacromolecules with fluorocarbon-modified chitosan for melanoma immunotherapy and viral vaccines |
Authors： | Wenjun Zhu1, Ting Wei1,2, Yuchun Xu1, Qiutong Jin1,2, Yu Chao1, Jiaqi Lu1,2, Jun Xu1, Jiafei Zhu1, Xiaoying Yan1, Muchao Chen1, Qian Chen1*& Zhuang Liu1,2* |
Institutions： | 1Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Soochow University, Suzhou 215123, China 2Suzhou InnoBM Pharmaceutics Co. Ltd., Suzhou, Jiangsu 215213, China |
Abstract： | Transdermal drug delivery has been regarded as an alternative to oral delivery and subcutaneous injection. However, needleless transdermal delivery of biomacromolecules remains a challenge. Herein, a transdermal delivery platform based on biocompatible fluorocarbon modified chitosan (FCS) is developed to achieve highly efficient non-invasive delivery of biomacromolecules including antibodies and antigens. The formed nanocomplexes exhibits effective transdermal penetration ability via both intercellular and transappendageal routes. Non-invasive transdermal delivery of immune checkpoint blockade antibodies induces stronger immune responses for melanoma in female mice and reduces systemic toxicity compared to intravenous injection. Moreover, transdermal delivery of a SARS-CoV-2 vaccine in female mice results in comparable humoral immunity as well as improved cellular immunity and immune memory compared to that achieved with subcutaneous vaccine injection. Additionally, FCS-based protein delivery systems demonstrate transdermal ability for rabbit and porcine skins. Thus, FCS-based transdermal delivery systems may provide a compelling opportunity to overcome the skin barrier for efficient transdermal delivery of bio-therapeutics. |
IF： | 17.694 |
Link： | https://www.nature.com/articles/s41467-024-45158-6 |
Editor: Guo Jia