Angew. Chem. Int. Ed.: Oxygen-Deficient Molybdenum Oxide Nanosensitizers for Ultrasound-Enhanced Cancer Metalloimmunotherapy

Title：

Oxygen-Deficient Molybdenum Oxide Nanosensitizers for Ultrasound-Enhanced Cancer Metalloimmunotherapy

Authors：

Yuanjie Wang¹, Fei Gong¹*, Zhihui Han¹, Huali Lei¹, Yangkai Zhou¹, Shuning Cheng¹, Xiaoyuan Yang¹, Tianyi Wang², Li Wang¹, Nailin Yang¹, Zhuang Liu¹, and Liang Cheng¹*

Institutions：

¹Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu. Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, Suzhou 215123 , China.

²Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou 215000,   China.

Abstract：

Oxygen-deficient molybdenum oxide (MoO_X) nanomaterials are prepared as novel nanosensitizers and TME-stimulants for ultrasound (US)-enhanced cancer metalloimmunotherapy. After PEGylation, MoO_X-PEG exhibits efficient capability for US-triggered reactive oxygen species (ROS) generation and glutathione (GSH) depletion. Under US irradiation, MoO_X-PEG generates a massive amount of ROS to induce cancer cell damage and immunogenic cell death (ICD), which can effectively suppress tumor growth. More importantly, MoO_X-PEG itself further stimulates the maturation of dendritic cells (DCs) and triggeres the activation of the cGAS-STING pathway to enhance the immunological effect. Due to the robust ICD induced by SDT and efficient DC maturation stimulated by MoO_X-PEG, the combination treatment of MoO_X-triggered SDT and aCTLA-4 further amplifies antitumor therapy, inhibits cancer metastases, and elicits robust immune responses to effectively defeat abscopal tumors.

IF：

16.823

Link：

https://onlinelibrary.wiley.com/doi/10.1002/anie.202215467