题目： | Emerging Co-Assembled and Sustained Released Natural Medicinal Nanoparticles for Multitarget Therapy of Choroidal Neovascularization |
作者： | Jingjing Shen1, Linfu Chen1, Xinying Lv1, Nanhui Liu1, Yu Miao1, Qiang Zhang2, Zhisheng Xiao1, Maoyi Li1, Yang Yang2,3,4, Zhuang Liu1, and Qian Chen1* |
单位： | 1Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, Suzhou 215123, P. R. China. Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, Suchow 215123,China 2School of Materials Science and Engineering, Tongji University, Shanghai 201804, China 3Department of Thoracic Surgery Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, P. R. China 4Central Laboratory, Shanghai Pulmonary Hospital School of Medicine, Tongji University, Shanghai 200433, China |
摘要： | Age-related macular degeneration (AMD) disease has become a worldwide senile disease, and frequent intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF) is the mainstream treatment in the clinic, which is associated with sight-threatening complications. Herein, nintedanib, an inhibitor of angiogenesis, and lutein, a potent antioxidant, can co-assemble into nanoparticles through multiple noncovalent interactions. Interestingly, the co-assembled lutein/nintedanib nanoparticles (L/N NPs) exhibit significantly improved stability and achieve long-term sustained release of two drugs for at least two months in mice. Interestingly, in rabbit eyeball with a more complete barrier system, the L/N NPs still successfully distribute in the retina and choroid for a month. In the laser-induced mouse choroidal neovascularization model, the L/N NPs after a minimally invasive subconjunctival administration can successfully inhibit angiogenesis and achieve comparable and even better therapeutic results to that of standard intravitreal injection of anti-VEGF. Therefore, the subconjunctival injection of L/N NPs with long-term sustained drug release behavior represents a promising and innovative strategy for AMD treatment. Such minimally invasive administration together with the ability to effectively inhibit angiogenesis reduce inflammation and counteract oxidative stress and holds great potential for improving patient outcomes and quality of life in those suffering from this debilitating eye condition. |
影响因子： | 32.086 |
分区情况： | 一区 |
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责任编辑：郭佳