刘庄教授课题组及其合作者在 Angew. Chem. Int. Ed.上发表论文

题目：

Precise Epitope Organization with Self-adjuvant Framework Nucleic Acid for Efficient COVID-19 Peptide Vaccine Construction

作者：

Fengyun Shen^1,3, Zijian Xiong¹, Yumin Wu¹, Rui Peng¹, Yue Wang³, Lele Sun²*, Chunhai Fan³ & Zhuang Liu¹*

单位：

¹Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Lab Carbon Based Functional Material, Soochow University, Suzhou 215123, P. R. China.

²School of Life Sciences, Shanghai University, Shanghai 200444, P. R. China.

³School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 201240, P. R. China.

摘要：

Peptide vaccines have advantages in easy fabrication and high safety, but their effectiveness is subjected to the poor immunogenicity of epitopes themselves. Herein, we constructed a series of framework nucleic acids (FNAs) with regulated rigidity and size as self-adjuvant carriers to precisely organize epitopes, in order to reveal the influence of epitope spacing and carrier rigidity on the efficiency of peptide vaccines. We found that assembling epitopes on rigid tetrahedral FNAs (tFNAs) with the appropriate size could efficiently enhance their immunogenicity. Further, by integrating epitopes from SARS-CoV-2 on preferred tFNAs, we constructed a COVID-19 peptide vaccine which could induce high titers of IgG against the receptor binding domain (RBD) of SARS-CoV-2 spike protein, and increase the ratio of memory B and T cells in mice. Considering the good biocompatibility of tFNAs, our research provided a new idea for developing efficient peptide vaccines against viruses and possibly other diseases.

影响因子：

16.823

分区情况：

一区

链接：

https://onlinelibrary.wiley.com/doi/10.1002/anie.202301147