FACULTY

Yaohua Song, Ph.D.

Education:

1979-1984 BS， Capital Medical University, China
1986-1991 Ph.D., Medical Chemistry, Uppsala University, Sweden

Professional Experience:

2006 -2011 Associate Professor, MD Anderson Cancer Center, USA
2011-Present Professor/Principal Investigator, Cyrus Tang Hematology Center, Soochow University, China

Research:

Muscle wasting is a complication of many chronic diseases such as cancer, diabetes, kidney disease and aging. Our research team mainly focuses on the mechanisms of muscle wasting, how satellite cells contribute to muscle regeneration and the role of cirdian clock in muscle maintenance.

Investigators:

Chaofan Wu, Ph.D. student
Jiqing zheng, Ph.D. student
Hui Ding, Master degree student

Shouchen Wang, Master degree student

Ting Xue, Master degree student

Jing Lou, Master degree student

Yanfang Li. Master degree student

Representative Publications:

1.Song YH, Connor E, Li Y, Zorovich B, Balducci P, Maclaren N. The role of tyrosinase in autoimmune vitiligo. Lancet 1994；344(8929):1049-52.

2. Song YH. Why tyrosinase for treatment of melanoma. Lancet 1997；350(9071):82-3.

3. Delafontaine P, Song YH, Li Y. Expression, regulation, and function of IGF-1, IGF-1R, and IGF-1 binding proteins in blood vessels. Arterioscler Thromb Vasc Biol 2004;24:1-10.

4. Song YH, Li Y, Du J, Mitch WE, Rosenthal N, Delafontaine P. Muscle-specific expression of IGF-1 blocks angiotensin II-induced skeletal muscle wasting. J Clin Invest 2005;115:451-458.

5. Song YH. Comments on Point:Counterpoint: IGF is/is not the major physiological regulator of muscle mass. IGF-1 plays a unique role in muscle regeneration. J Appl Physiol 2010;108:1830-1831

6. Tang X, Song YH, Sun A, Zhu X, Ruan C, Wu D. Successful treatment of relapsed acute myeloid leukemia without chemotherapy. Journal of Clinical Oncology, 2016；34(13):e117-9

7.Zhou J, Liu B, Liang C, Li Y, Song YH. Cytokine Signaling in Skeletal Muscle Wasting.Trends Endocrinol Metab. 2016；27(5):335-347.

8. Li Y, Zhou J, Song YH, Yu XY. Dominant and recessive imprinting of exosomes from parent cells. Nature Review Cardiology. 2017；14(8):491

9. Shen C, Zhou J, Wang X, Yu XY, Liang C, Liu B, Pan X, Zhao Q, Song JL, Wang J, Bao M, Wu C, Li Y, Song YH. Angiotensin-II-induced Muscle Wasting is Mediated by 25-Hydroxycholesterol via GSK3β Signaling Pathway.EBioMedicine. 2017；16:238-250.

10. Wang B, Zheng J, Chen Q, Wu C, Li Y, Yu XY, Liu B, Liang C, Liu SB, Ding H, Wang S, Xue T, Song D, Lei Z, Amin HM, Song YH, Zhou J. CLIC4 abrogation promotes epithelial mesenchymal transition in gastric cancer. Carcinogenesis. 2019 Sep 27.

11. Wu C, Ding H, Wang S, Li Y, Liu SB, Wang X, Zheng J, Xue T, Amin HM, Song YH, Zhou J. DAXX inhibits cancer stemness and epithelial-mesenchymal transition in gastric cancer. Br J Cancer. 2020 Mar 23.

Others:

Member of the American Heart Association

American Association for the Advancement of Science