199 Ren'ai Rd. Suzhou, Jiangsu 215123, P.R.China
Cyrus Tang Hematology Center, Soochow University
Phone: 86-512-65880899 EXT 3509
Fax: 86-512-65882122
Email: Zhul@suda.edu.cn
Education:
1978-1984 M.D., School of Medicine, Norman Bethune University (currently Jilin University), China
1986-1989 M.S., Anti-infectious Immunity, Norman Bethune University, China
1992-1998 Ph.D., Immunology, Joint Program in Biomedical Sciences (Norman Bethune University, UCSF, and University of Ottawa) sponsored by Cheng Scholar Program and operated by the Ministry of Health of China
1999-2002 Postdoctoral Fellow, Department of Medicine, Thomas Jefferson University, USA
Professional Experience:
2002-2008 Senior Research Investigator, Division of Hematology and Oncology, Department of Medicine, University of Pennsylvania, USA
2008-2009 Staff Scientist, Bayer Healthcare Pharmaceuticals, Molecular Pharmacology and Hematology, USA
2009-Present Professor/Principal Investigator, Cyrus Tang Hematology Center, Soochow University, China
Research:
l Thrombosis, hemostasis and vascular biology
Investigators:
Chaojun Tang, Ph.D., Associate Research Fellow
Lijie Ren, M.S., Senoir Research Associate
Qiongyu Lu, M.S., Senoir Research Associate
Xiaohui Liu, Ph.D. Student
Fei Yang, Ph.D. Student
Zhao Zeng, Ph.D. Student
Qiang Li, Master Student
Wenxiu Yi, Master Student
Jian Shen, Master Student
Shuhong Hu, Master Student
Ting Chen, Master Student
Dongzhou Xu, Master Student
Representative Publications:
A. Original articles:
1. Qiongyu Lu, Ningzheng Dong, Qi Wang, Wenxiu Yi, Yuxin Wang, Shengjie Wang, Haibo Gu, Xin Zhao, Xiaorong Tang, Boquan Jin, Qingyu Wu, Lawrence F. Brass, and Li Zhu. Increased levels of Plasma Soluble Sema4D in Patients with Heart Failure. PloS One 2013;8(5)e64265.
2. Peipei Mou, Zhao Zeng, Qiang Li, Xiaohui Liu, Xiaoran Xin, Kenneth M. Wannemacher, Changgeng Ruan, Renhao Li, Lawrence F. Brass and Li Zhu. Identification of a Calmodulin-binding Domain in Sema4D that Regulates its Exodomain Shedding in Platelets. Blood 2013;121:4221-4230.
3. Kenneth M. Wannemacher*, Li Zhu*, Hong Jiang, Karen P. Fong, Timothy J. Stalker, Dooyoung Lee, Anh N. Tran, Keith Neeves, Sean Maloney, Atsushi Kumanogoh, Hitoshi Kikutani, Daniel A. Hammer, Scott L. Diamond and Lawrence F. Brass. Diminished contact-dependent reinforcement of Syk activation underlies impaired thrombus growth in mice lacking Semaphorin 4D. Blood. 2010;116:5705-5715.
4. Li Zhu, Timothy J. Stalker, Karen P. Fong, Hong Jiang, Anh Tran, Irene Crichton, Eric K. Lee, Keith B. Neeves, Sean F. Maloney, Hitoshi Kikutani, Atsushi Kumanogoh, Ellen Pure, Scott L. Diamond and Lawrence F. Brass. Disruption of sema4D ameliorates platelet hypersensitivity in dyslipidemia and confers protection against the development of atherosclerosis. Arterioscler Thromb Vasc Biol 2009; 29:1039-1045.
5. Li Zhu, Wolfgang Bergmeier, Jie Wu, Hong Jiang, Timothy J. Stalker, Marcin Cieslak, Ran Fan, Laurence Boumsell, Atsushi Kumanogoh, Hitoshi Kikutani, Luca Tamagnone, Denisa D. Wagner, Marcos E. Milla and Lawrence F. Brass. Regulated surface expression and shedding support a dual role for semaphorine 4D in platelet responses to vascular injury. Proc Natl Acad Sci 2007;104:1621-1626.
6. Suzanne Paradis, Dana B. Harrar, Yingxi Lin, Alex C. Koon, Jessica L. Hauser, Eric C. Griffith, Li Zhu, Lawrence F. Brass, Chinfei Chen, and Michael E. Greenberg. An RNAi-based approach identifies molecules required for glutamatergic and GABAergic synapse development. Neuron 2007;53:217-232.
7. Xiangdong Wu*, Li Zhu *, Assaf Zilbering, Mahadev Kalyankar, Susie Hong, Junli Yao and Barry J. Goldstein. Hyperglycemia potentiates H2O2 production in adipocytes and enhances insulin signal transduction: potential role for the oxidative inhibition of thiol-sensitive protein-tyrosine phosphatases. Antioxid. Redox Signal 2005;7:526-537. *co-first authors
8. Li Zhu, Assaf Zilbering, Xiangdong Wu, Mahadev Kalyankar, Jeffrey I. Joseph, Serge Jabbour, Wasim Deeb and Barry J. Goldstein: Use of an anaerobic environment to preserve the endogenous activity of protein-tyrosine phosphatases isolated from intact cells. FASEB J 2001;15:1637-1639.
9. Barry J. Goldstein, Li Zhu（朱力）, Richard Hager, Assaf Zilbering, Yanjie Sun and Vincent JB: Enhancement of post-receptor insulin signaling by trivalent chromium in hepatoma cells may involve differential inhibition of specific protein-tyrosine phosphatases. Journal of Trace Elements in Experimental Medicine 2001;14:393-404.
10. Mahadev Kalyankar, Assaf Zilbering, Li Zhu, and Barry J. Goldstein: Insulin-stimulated generation of hydrogen peroxide reversibly inhibits PTP1B and enhances the early insulin action cascade. J Biol Chem 2001;276:21938-21942.
11. Li Zhu, Nick Ohan, Yehenew Agazie, Cathy Cummings, Sahar Farah and X. Johne Liu: Molecular cloning and characterization of xenopus insulin-like growth factor-1 (IGF-1) receptor: Its role in mediating xenopus oocyte maturation and expression during embryogenesis. Endocrinology 1998;139:949-959.
12. Cathy Cummings, Li Zhu, Alexander Sorisky and X. Johne Liu: A peroxovanadium compound induces xenopus oocyte maturation: Inhibition by a neutralizing anti-insulin receptor antibody. Dev Biol 1996;175:338-346.
13. Xingquan Liu, Alexander Sorisky, Li Zhu and Tony Pawson: Molecular Cloning of an amphibian IRS-l cDNA and involvement of phosphatidylinositol 3-kinase in insulin-induced xenopus oocyte maturation. Mol Cell Biol 1995;15:3563-3570.
14. Victoria A. Mancuso, Thomas J. Hope, Li Zhu, David Derse, Tom Philips and Tristram G. Parslow: Posttranscriptional effector domains in the Rev proteins of feline immunodeficiency virus and equine infectious anemia virus. J Virol 1994; 68:1998-2001.
15. Li Zhu, Thomas G. Hope, Jackson Hall, Anthony Davies, Michael Stern, Ursula Muller-Eberhard, Robert Stern and Tristram G. Parslow: Molecular cloning of a mammalian hyaluronidase reveals identity with hemopexin, a serum heme-binding protein. J Biol Chem 1994;269:32092-32097.
B. Review articles and book chapters:
1. Lawrence F. Brass, Li Zhu, and Timothy J. Stalker. Novel therapeutic targets at the platelet vascular interface. Arterioscler Thromb Vasc Biol 2008;28:s43-50.
2. Lawrence F. Brass, Timothy J. Stalker, Li Zhu, and Donna S. Woulfe. Signal transduction during platelet plug formation. In A. D. Michelson (ed), Platelets Academic Press, 2007; p319-357.
3. Lawrence F. Brass, Li Zhu, and Timothy J. Stalker. Minding the gaps to promote thrombus growth and stability. J Clin Invest 2005;115:3385-3392.
4. Barry J. Goldstein, Mahadev Kalyankar, Xiangdong Wu, Li Zhu, Hiroshima Motoshima. Role of insulin-induced reactive oxygen species in the insulin signaling pathway. Antioxid Redox Signal 2005;7(7-8):1021-31.
5. Lawrence F. Brass, Timothy J. Stalker, Li Zhu, Boxun Lu, Donna S. Woulfe, Nicholas Prevost. Boundary events: contact-dependent and contact-facilitated signaling between platelets. Semin Thromb Hemost 2004;30(4):399-410.
6. Li Zhu and Barry J. Goldstein. Use of an anaerobic chamber environment for the assay of endogenous cellular protein-tyrosine phosphatase activities. Biol Proced Online, 2002, 4:1-9.
Awards:
1) Bradley Award in Bench Research, Department of Medicine, University of Pennsylvania, April 27, 2005.
2) Cheng Scholars Award, Department of Pathology, University of California, San Francisco, 1992-1994.
Grant Support:
1) Regular Grant, Natural Science Foundation of China (Ref#: NSFC 81070410), RMB 350,000, 2011.1-2013.12
2) Regular Grant, Natural Science Foundation of China (Ref#: NSFC 81170132), RMB 650,000, 2012.1-2015.12
3) PhD training grant, Ministry of Education of China (Ref#: K521102111), RMB 120,000, 2012.01-2014.12
Memberships:
1) Vice President, Subcommettee of Atherosclerosis, Chinese Society of Pathophysiology (2011-2015)
2) Committee member, National Standardization Committee of China (2011-2016)
3) Member, American Society of Hematology (ASH), 2003-now.
4) Member, International Society on Thrombosis and Homeostasis (ISTH), 2007-now.
5) Member, Editorial board of Chinese Journal of Arteriosclerosis