Education:

1982-1987 M.D., Medicine, Hebei Medical University
1991-1994 M.Sc., Medicine, Hebei Medical University
1997-2002 Ph.D., Biochemistry, Yamanashi University School of Medicine
2002-2005 PostDoc., Molecular Biology, UMDNJ-New Jersey Medical School

Professional Experience:

2005-2008 Assistant Professor, Temple University School of Medicine, Sol Sherry Thrombosis Research Center
2009-Present Professor/Principal Investigator, Cyrus Tang Hematology Center, Soochow University, China

Research:

1) Molecular and cellular mechanisms of thrombosis
(1) Signal transduction of platelet activation
(2) Mechanism of coagulation cascade
2) Role of plasma kallikrein-kinin system in thrombosis, vascular biology and inflammation
3) Recognition and uptake of apoptotic cells in innate immunity

Investigators:

Aizhen Yang, Ph.D..Associate Researcher
Lu Wang, Master Student
Bo Wang, Master Student
Xichen Zhen, Master Student

Representative papers:

1. Yi Wu, Y. Ozaki, K. Inoue, K. Satoh, T. Ohmori, Y. Yatomi, K. Owada. Differential activation and redistribution of c-Src and Fyn in platelets, assessed by MoAb specific for C-terminal tyrosine-dephosphorylated c-Src and Fyn. Biochimica et Biophysica Acta-Molecular Cell Research 2000;1497:27-36.
2. K. Inoue, Y. Ozaki, M. Kainoh, Y. Shin, Yi Wu, Y. Yatomi, T. Ohmori, T. Tanaka, K. Satoh, and T. Morita. Rhodocytin induces platelet aggregation by interacting with glycoprotein Ia/IIa: involvement of GPIa/IIa-associated Src and protein tyrosine phosphorylation. Journal of Biological Chemistry 2001;276:1643-1652.
3. Yi Wu, K. Inoue-Suzuki, K. Satoh, N. Asazuma, Y. Yatomi, M.C. Berndt, and Y. Ozaki. Role of Fc receptor ?-chain in platelet glycoprotein Ib-mediated signaling. Blood 2001;97(12):3836-3845.
4. Yi Wu, N. Asazuma, K. Satoh, T. Takafuta, Y. Yatomi, M.C. Berndt, and Y. Ozaki. Interaction between von Willebrand factor and glycoprotein Ib activates Src kinase in human platelets: role of phosphoinositide 3-kinase. Blood 2003;101(9):3469-3476.
5. Yi Wu, S. Singh, M.M. Georgescu, R.B. Birge. A role for Mer tyrosine kinase in ?v?5 integrin-mediated phagocytosis of apoptotic cells. Journal of Cell Science 2005;118(3):539-553.
6. Yi Wu, N. Tibrewal, R.B. Birge. Phosphatidylserine recognition by phagocytes: a view to a kill. Trends in Cell Biology 2006;16(4):189-97.
7. M.M. Khan, H.N. Bradford, I. Isordia-Salas, Y. Liu, Yi Wu, B. Ghebrehiwet, R.W. Colman. High molecular weight kininogen fragments stimulate the secretion of cytokines and chemokines through uPAR, Mac-1 and gC1qR in monocytes. Arteriosclerosis, Thrombosis and Vascular Biology 2006;26(10):2260-6.
8. Yi Wu, V. Rizzo, Y. Liu, I. Sainz, N. Schmuckler, R.W. Colman. Kininostatin associates with caveolae and inhibits ?v?3 integrin activation in human umbilical vein endothelial cells. Arteriosclerosis, Thrombosis and Vascular Biology 2007;27(9):1968 -75. (Correspondence author).
9. N. Tibrewal*, Yi Wu*, V. D’Mello, R. Akakura, B. Varnum, R.B. Birge. Autophosphorylation of docking site Tyr867 in Mertk allows for dissociation of multiple signaling pathways for the phagocytosis of apoptotic cells and down-modulation of LPS-inducible NF-?B transcriptional activation. Journal of Biological Chemistry 2008;283(6):3618-27. (* equal first-author).
10. V. D'mello, S. Singh, Yi Wu, and R.B. Birge. The urokinase plasminogen activator receptor promotes efferocytosis of apoptotic cells. Journal of Biological Chemistry 2009;284: 17030-17038.
11. Yi Wu, J. Dai, N.G. Schmuckler, M.C. Yoder, C.M. Overall, R.W. Colman. Cleaved kininogen inhibits endothelial progenitor cell differentiation via suppression of matrix metallopeptidase 2. Journal of Thrombosis and Haemostasis, 2010;8(1):185-93. (Correspondence author).
12. R.W. Colman, Yi Wu, Y. Liu. Mechanisms by which cleaved kininogen inhibits endothelial cell differentiation and signalling. Thromb Haemost. 2010;104(5):875-85.
13. J. Dai, X. Zhu, M.C. Yoder, Yi Wu, R.W. Colman Cleaved high molecular weight kininogen accelerates senescence of endothelial progenitor cells by induction of reactive oxygen species. Arteriosclerosis, Thrombosis and Vascular Biology, 2011;31(4):883-889. (Correspondence author).
14. Wu Y, Ahmad SS, Zhou J, Wang L, Cully MP, Essex DW. The disulfide isomerase ERp57 mediates platelet aggregation, hemostasis, and thrombosis. Blood. 2012 Feb 16;119(7):1737-46.
15. Dai J, Agelan A, Yang A, Zuluaga V, Sexton D, Colman RW, Wu Y. A role for activation of the kallikrein-kinin system in the synovial recruitment of endothelial progenitor cells in arthritis. Arthritis Rheum. 2012;64:3574-82.

Others:

Thrombosis Research, Editorial Board (2008~)