教育背景：

2005~2009 北京理工大学 生物工程专业理学学士
2009~2015 北京大学 生理学专业理学博士，导师 王世强教授
2015~2019 美国纽约大学医学院 博士后，合作导师 William Coetzee教授

工作经历：

2019~2020 美国纽约大学医学院 研究助理教授、电生理实验中心执行主任
2021~至今 18新利体育 苏州医学院唐仲英医学研究院 特聘教授

研究领域：

心血管电生理课题组以膜片钳等技术研究心血管系统中的离子通道功能及其相关的心血管疾病。主要研究方向包括：
1）ATP敏感钾离子通道（KATP）的转运及在心脏缺血损伤中的保护作用；
2）β肾上腺素受体信号通路对心肌细胞钙稳态的调节及在心肌肥大模型中的作用；
3）新型离子通道的鉴定及其门控性质和通道动力学参数的研究。

承担项目：

1）国家自然科学基金面上项目（82270268）；2023-2026；主持
2）江苏省面上项目（BK20221358）；2022-2025；主持
3）苏州市科协青年科技人才托举工程项目；2021-2022，主持
4）信达生物制药有限公司横向项目；2021-2023；主持
5）江苏省“双创”博士（JSSCBS20210692)

代表性成果：(* equal contribution, # corresponding author)

1.Yang B, Yao JL, Huo JY, Feng YL, Coetzee WA, Xu GY, Yang HQ#. Rab35 GTPase positively regulates endocytic recycling of cardiac KATP channels. Channels (Austin). 2022 Dec;16(1):137-147.
2.Yang HQ, Echeverry FA, ElSheikh A, Gando I, Anez Arredondo S, Samper N, Cardozo T, Delmar M, Shyng SL, Coetzee WA#. Subcellular trafficking and endocytic recycling of KATP channels. Am J Physiol Cell Physiol. 2022 Jun 1;322(6):C1230-C1247.
3.Yang HQ*, Zhou P*, Wang LP*, Zhao YT, Guo YB, Xu, M, Wang SQ#. Compartmentalized β1-adrenergic signaling synchronizes excitation-contraction coupling without modulating individual Ca2+ sparks in healthy and hypertrophied cardiomyocytes. Cardiovasc Res. 2020 Nov 1;116(13):2069-2080.
4.Yang HQ, Martinez-Ortiz W, Hwang J, Fan X, Cardozo TJ, Coetzee WA#. Palmitoylation of the KATP channel Kir6.2 subunit promotes channel opening by regulating PIP2 sensitivity. Proc Natl Acad Sci U S A. 2020 May 12;117(19):10593-10602.
5.Yang HQ, Pérez-Hernández M, Sanchez Alonso JL, Shevchuk A, Gorelik J, Rothenberg E, Delmar M, Coetzee WA#. Ankyrin-G Mediates Targeting of both Na+ and KATP Channels to the Cardiac Intercalated Disc. eLife. 2020 Jan 14;9:e52373.
6.Yang HQ*, Wang LP*, Gong YY*, Fan XX*, Zhu SY*, Wang XT, Wang YP, Li LL, Xing X, Liu XX, Ji GS, Hou TT, Zhang Y, Xiao RP, Wang SQ#. β2-Adrenergic Stimulation Compartmentalizes β1 Signaling into Nanoscale Local Domains by Targeting the C-Terminus of β1-Adrenoceptors. Circ Res. 2019 Apr 26;124(9):1350-1359.
7.Yang HQ, Jana K, Rindler MJ, Coetzee WA#. The trafficking protein, EHD2, positively regulates cardiac sarcolemmal KATP channel surface expression: role in cardioprotection. FASEB J. 2018 Mar;32(3):1613-1625.
8.Yang HQ, Foster MN, Jana K, Ho J, Rindler MJ, Coetzee WA#. Plasticity of sarcolemmal KATP channel surface expression: relevance during ischemia and ischemic preconditioning. Am J Physiol Heart Circ Physiol. 2016 Jun 1;310(11):H1558-66.

其余已发表论文：(* equal contribution, # corresponding author)

9.Gando I, Yang HQ, Coetzee WA#. Functional significance of channelopathy gene variants in unexplained death. Forensic Sci Med Pathol. 2019 Sep;15(3):437-444.
10.Subbotina E, Yang HQ, Gando I, Williams N, Sampson BA, Tang Y, Coetzee WA#. Functional characterization of ABCC9 variants identified in sudden unexpected natural death. Forensic Sci Int. 2019 May;298:80-87.
11.Cerrone M*, Montnach J*, Lin X*, Zhao YT, Zhang M, Agullo-Pascual E, Leo-Macias A, Alvarado FJ, Dolgalev I,Karathanos TV, Malkani K, Van Opbergen CJM, van Bavel JJA, Yang HQ, Vasquez C, Tester D, Fowler S, Liang F, Rothenberg E, Heguy A, Morley GE, Coetzee WA, Trayanova NA, Ackerman MJ, van Veen TAB, Valdivia HH, Delmar M#. Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm. Nat Commun. 2017 Jul 24;8(1):106.
12.Zhao YT, Guo YB, Gu L, Fan XX, Yang HQ, Chen Z, Zhou P, Yuan Q, Ji GJ, Wang SQ#. Sensitized signalling between L-type Ca2+ channels and ryanodine receptors in the absence or inhibition of FKBP12.6 in cardiomyocytes. Cardiovasc Res. 2017 Mar 1;113(3):332-342.
13.He LH, Liu M, He Y, Xiao E, Zhao L, Zhang T, Yang HQ, Zhang Y#. TRPV1 deletion impaired fracture healing and inhibited osteoclast and osteoblast differentiation. Sci Rep. 2017 Feb 22;7:42385.
14.Yang HQ, Subbotina E, Ramasamy R, Coetzee WA#. Cardiovascular KATP channels and advanced aging. Pathobiol Aging Age Relat Dis. 2016 Oct 11;6:32517.
15.Xiao E*, Yang HQ*, Gan YH, Duan DH, He LH, Guo Y, Wang SQ#, Zhang Y#. TRPM7 Senses Mechanical Stimulation Inducing Osteogenesis in Human Bone Marrow Mesenchymal Stem Cells. Stem Cells. 2015 Feb;33(2):615-21.
16.Rong J*, Han J*, Dong L, Tan Y, Yang H, Feng L, Wang QW, Meng R, Zhao J, Wang SQ#, Chen X#. Glycan imaging in intact rat hearts and glycoproteomic analysis reveal the upregulation of sialylation during cardiac hypertrophy. J Am Chem Soc. 2014 Dec 17;136(50):17468-76.
17.Wang C, Chi Y, Li J, Miao Y, Li S, Su W, Jia S, Chen Z, Du S, Zhang X, Zhou Y, Wu W, Zhu M, Wang Z, Yang H, Xu G, Wang S, Yang J, Guan Y#. FAM3A activates PI3K p110α/Akt signaling to ameliorate hepatic gluconeogenesis and lipogenesis. Hepatology. 2014 May;59(5):1779-90.
18.Wang SQ#, Yang HQ. The molecular mechanism of cardiomyocyte excitation-contraction coupling. Science China Life Sciences. 2013;43(10):833~841.
19.Li RC*, Tao J*, Guo YB*, Wu HD, Liu RF, Bai Y, Lv ZZ, Luo GZ, Li LL, Wang M, Yang HQ, Gao W, Han QD, Zhang YY, Wang XJ, Xu M, Wang SQ#. In vivo suppression of microRNA-24 prevents the transition toward decompensated hypertrophy in aorticconstricted mice. Circ Res. 2013 Feb 15;112(4):601-5.
20.Xu M*, Wu HD*, Li RC*, Zhang HB, Wang M, Tao J, Feng XH, Guo YB, Li SF, Lai ST, Zhou P, Li LL, Yang HQ, Luo GZ, Bai Y, Xi JJ, Gao W, Han QD, Zhang YY, Wang XJ, Meng X, Wang SQ#. Mir-24 regulates junctophilin-2 expression in cardiomyocytes. Circ Res. 2012 Sep 14;111(7):837-41.

学术活动：

1）Cell Biochemistry and Biophysics审稿人
2）中国生理学会张锡钧基金第十六届全国青年优秀论文奖
3）第4届土耳其暨国际生物物理大会科学委员会成员及特邀报告

团队成员：

杨波 （2022级博士研究生）
霍建一（2021级硕士研究生）
冯雨龙（2021级硕士研究生）
王皓洁（2022级硕士研究生）
支亚婷（2022级硕士研究生）
陈玥彤（2019级本科生）
车舒涵（2021级本科生）