戴克胜
教授，博士生导师
江苏省苏州市工业园区仁爱路199号703号楼B613室
18新利体育
唐仲英医学研究院
电话：86-512-65880877
Email：kdai@suda.edu.cn
教育背景：
1984-1988年，蚌埠医学院 学士
1994-1996年，中山大学(原中山医科大学) 硕士
1999-2002年，18新利体育
博士
2002-2005年，美国University of Illinois 博士后
工作经历：
1988-1999年，蚌埠医学院，血液学教研室，助教、讲师、副教授、教研室主任
2005-2011年，北京航空航天大学，“蓝天学者”特聘教授，生物与医学工程学院教授、博士生导师
2011年-至今，18新利体育
“特聘教授”，18新利体育
附属第一医院 江苏血液研究所 教授
2019年-至今，18新利体育
，唐仲英医学研究院 教授
研究领域：
1、血小板数量、功能调控机制及其相关疾病诊断、治疗研究。
2、血小板在心脑血管、肿瘤、感染、代谢等重大疾病中的作用及其防治研究。
团队成员:
学术骨干
万俊 副教授 研究生导师 [点击进入个人主页]
工作人员
闫 荣，博士，副研究员
赵丽丽，博士，助理研究员
刘春亮，博士，助理研究员
胡仁萍，硕士，研究实习员
博士后
田璟鸾，博士
研究生
博士研究生：肖伟玲，庞宁波，葛鑫鑫，周康熙，孙月月，Muhammad Khan
硕士研究生：张素勤，成斌，袁柳霞，杨梦楠，夏月，胡颖，孙成林
科研成果：
代表性论文:
1. Chen M, Yan R, Zhou K, Li X, Zhang Y, Liu C, Jiang M, Ye H, Meng X, Pang N, Zhao L, Liu J, Xiao W, Hu R, Cui Q, Zhong W, Zhao Y, Zhu M, Lin A, Ruan C, Dai K. Akt-mediated platelet apoptosis and its therapeutic implications in immune thrombocytopenia. Proc Natl Acad Sci U S A 2018;115(45):E10682-91.
2. Zhao L, Liu J, He C, Yan R, Zhou K ,Cui Q, Meng X, Li X, Zhang Y, Nie Y, Zhang Y, Hu R, Liu Y, Zhao L, Chen M, Xiao W, Tian J, Zhao Y, Cao L, Zhou L, Lin A, Ruan C, Dai K. Protein kinase A determines platelet lifespan and survival by regulating apoptosis. Journal of Clinical Investigation 2017;127(12):4338-51.
3. Zhang Y, Zhang J, Yan R, Tian J, Zhang Y, Zhang J, Chen M, Cui Q, Zhao L, Hu R, Jiang M, Li Z, Ruan C, He S, Dai K. Receptor-interacting protein kinase 3 promotes platelet activation and thrombosis. Proc Natl Acad Sci U S A 2017;114(11):2964-69.
4. Liu L, Chen M, Zhao L, Zhao Q, Hu R, Zhu J, Yan R, Dai K. Ethanol Induces Platelet Apoptosis. Alcoholism: Clinical and Experimental Research 2017; 41(2): 291–298.
5. Zhao Q, Li M, Chen M, Zhou L, Zhao L, Hu R, Yan R, Dai K. Lovastatin induces platelet apoptosis. Environmental Toxicology and Pharmacology 2016;42:69-75.
6. Yan R, Chen M, Ma N, Zhao L, Cao L, Zhang Y, Zhang J, Yu Z, Wang Z, Xia L, Ruan C, Dai K. Glycoprotein Ibα clustering induces macrophage-mediated platelet clearance in the liver. Thrombosis and Haemostasis 2015;113(1):107-17.
7. Zhao L, Lu G, Zhao Q, Zhang M, Chen M, Zhang J, Dai K. Staurosporine Induces Platelet Apoptosis Through p38 Mitogen-Activated Protein Kinase Signaling Pathway. Clin Lab 2015;61(7):717-26.
8. Li J, Dai K, Wang Z, Cao L, Bai X, Ruan C. Platelet functional alterations in a Bernard-Soulier syndrome patient with filamin A mutation. J Hematol Oncol. 2015;8:79.
9. Wu Y, Dai J, Zhang W, Yan R, Zhang Y, Ruan C, Dai K. Arsenic trioxide induces platelet apoptosis. PLoS One 2014;9(1):e86445.
10. Zhang J, Chen M, Zhang Y, Zhao L, Yan R, Dai K. Carmustine induces platelet apoptosis. Platelets 2015;26(5):437-42
11. Li M, Wang Z, Ma T, Lu G, Yan R, Zhao L, Deng K, Dai K. Enhanced platelet apoptosis in chronic uremic patients. Renal Failure 2014;36:847-53.
12. Pan Y, Yago T, Fu J, Herzog B, McDaniel J, MehtaD'Souza P, Cai X, Ruan C, McEver J, West C, Dai K, Chen H, Xia L. Podoplanin requires sialylated O-glycans for stable expression on lymphatic endothelial cells and for interaction with platelets. Blood 2014;124(24):3656-65.
13. Shou LM, Zhang QY, Li W, Xie X, Chen K, Lian L, Li ZY, Gong FR, Dai KS, Mao YX, Tao M. Cantharidin and norcantharidin inhibit the ability of MCF-7 cells to adhere to platelets via protein kinase C pathway-dependent downregulation of α2 integrin. Oncol Rep 2013;30(3):1059-66.
14. Zhang P, Du J, Zhao L, Wang X, Zhang Y, Yan R, Dai J, Liu G, Zhang F, Dai K. The role of intraplatelet reactive oxygen species in the regulation of platelet glycoprotein Ibα ectodomain shedding. Thrombosis Research 2013;132(6):696-701.
15. Zhao L, Zhang W, Chen M, Zhang J, Zhang M, Dai K. Aspirin induces platelet apoptosis. Platelets 2013;24(8):637-42.
16. Zhang W, Zhao L, Liu J, Du J, Yan R, Dai K. Role of 14-3-3ζ in Platelet Glycoprotein Ibα-von Willebrand Factor Interaction-Induced Signaling. International Journal of Molecular Sciences 2012;13:5364-74.
17. Zhang W, Zhao L, Liu J, Du J, Wang Z, Ruan C, Dai K. Cisplatin induces platelet apoptosis through the ERK signaling pathway. Thrombosis Research 2012;13:81-91.
18. Yan R, Mo X, Paredes AM, Dai K, Lanza F, Cruz MA, Li R. Reconstitution of the Platelet Glycoprotein Ib-IX Complex in Phospholipid Bilayer Nanodiscs. Biochemistry 2011;50(49):10598-606.
19. Zhang W, Liu J, Sun R, Zhao L, Du J, Ruan C, Dai K. Calpain Activator Dibucaine Induces Platelet Apoptosis. International Journal of Molecular Sciences 2011;12:2125-37.
20. Li S, Wang Z, Liao Y, Zhang W, Shi Q, Yan R, Ruan C, Dai K. The glycoprotein Ibalpha-von Willebrand factor interaction induces platelet apoptosis. Journal of Thrombosis and Haemostasis 2010;8:341-50.
21. Wang Z, Shi Q, Yan R, Liu G, Zhang W, Dai K. The role of calpain in the regulation of ADAM17-dependent GPIb ectodomain shedding. Archives of Biochemistry and Biophysics 2010;495:136-43.
22. Li S, Shi Q, Liu G, Zhang W, Wang Z, Wang Y, Dai K. Mechanism of platelet functional changes and the effects of anti-platelet agents on in vivo hemostasis under different gravity conditions. Journal of Applied Physiology 2010;108:1241-49.
23. Wang Z, Shi Q, Li S, Du J, Liu J, Dai K. Hyperthermia induces platelet apoptosis and glycoprotein Ibα ectodomain shedding. Platelets 2010;21:229-37.
24. Wang Z, Li S, Shi Q, Yan R, Liu G, Dai K. Calmodulin antagonists induce platelet apoptosis. Thrombosis Research 2010;125:340-50.
25. Li G, Qu L, Meng G, Bai X, Dai K, Zheng X. Crystallization and preliminary X-ray crystallographic studies of human FAIM protein. Acta Crystallogr Sect F Struct Biol Cryst Commun 2010;66(Pt 8):935-7.
26. Yuan Y, Zhang W, Yan R, Liao Y, Zhao L, Ruan C, Du X, Dai K. Identification of a novel 14-3-3ζ binding site within the cytoplasmic domain of platelet glycoprotein Iba that plays a key role in regulating the VWF binding function of glycoprotein Ib-IX. Circulation Research 2009;105:1177-85.
27. Dai K, Wang Y, Yan R, Shi Q, Wang Z, Yuan Y, Cheng H, Li S, Fan Y, Zhuang F. Effects of microgravity and hypergravity on platelet function. Thrombosis and Haemostasis 2009;101:902-10. （Cover, Editorial focus）
28. Cheng H, Yan R, Li S, Yuan Y, Liu J, Ruan C, Dai K. Shear-induced von Willebrand factor-dependent platelet glycoprotein Ibα shedding. The American Journal of Physiology-Heart and Circulatory Physiology 2009;297:H2128-35.
29. Yan R, Wang Z, Yuan Y, Cheng H, Dai K. Role of cAMP-dependent protein kinase in the regulation of platelet procoagulant activity. Archives of Biochemistry and Biophysics 2009;485:41-8.
30. Yan R, Li S, Dai K. The critical roles for cyclic AMP/cyclic AMP-dependent protein kinase in platelet physiology. Frontiers of Biology in China, 2009;4:7-14.
31. Dai K, Yan R, Li S, Fan Y, Zhuang F, Ruan C. Prolonged inhibition of protein kinase A results in the dysfunction of platelet by GPIba shedding. Thrombosis Research 2009;124:101-9.
32. Li G, Tang Z, Meng G, Dai K, Zhao J, Zheng X. Crystallization and preliminary X-ray crystallographic studies of O-methyltransferase from Anabaena PCC 7120. Acta Cryst Structural Biology and Crystallization Communications 2009; F65:1039-41.
33. Li S, Shi Q, Wang Z, Yan R, Cheng H, Dai K. Hypergravity Results in Human Platelet Hyperactivity. Journal of Physiology and Biochemistry 2009;65:147-56.
34. Dai K, Bodnar R, Berndt MC, Du X. A critical role for 14-3-3 protein in platelet adhesion and its therapeutic implications. Blood 2005; 106:1975-81.
35. Dai K, Zhu H, Ruan C. Generation and characterization of recombinant single chain Fv antibody that recognizes platelet glycoprotein Ibalpha. Thrombosis Research 2003;109:137-44.
36. Dai K, Gao W, Ruan C. The Sma I polymorphism in the von Willebrand factor gene associated with acute ischemic stroke. Thrombosis Research 2001;104:389-95.
著作：
1. 董尔丹，张幼仪，戴克胜等，《血管生物学》，第二版，北京大学医学出版社，2014年。
2. 阮长耿，戴克胜等，主编，《中国工程科技论坛：血栓与血管生物学前沿》，高等教育出版社，2013年。
3. 侯明，戴克胜，彭军，主编，《血小板疾病》，第二版，科技文献出版社，2012年。
主要学术任职：
1. 国际宇航科学院 院士
2. 中国生理学会血栓与止血专业委员会 主任委员
3. 中国病生理学会微循环专业委员会 主任委员
4. 中国中西医结合微循环专业委员会 主任委员
5. 中国微循环学会痰瘀专业委员会 副主任委员
6. 中国医药质量管理协会临床试验及大数据质量管理分会 常务委员
7. 世界中医药联合会气血专业委员会 常务理事
8. 中华血液学分会血栓与止血学组 委员
9. 中国病生理学会实验血液学专业委员会 血管生物学组 副组长
10. 《Frontiers of Biology in China》杂志编委
11. 《中华现代临床医学杂志》杂志编委
12. 《血栓与止血学》杂志编委
13. 《World Journal of Traditional Chinese Medicine》杂志编委