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唐朝君
18新利体育
副研究员，生物医学工程博士
江苏省苏州市工业园区仁爱路199号703号楼3519室
18新利体育
唐仲英医学研究院
86-512-65880877-3519
E-mail: chaojun_tang@126.com
研究方向：
本团队一直致力于血流动力学诱导内皮表型转变及对动脉粥样硬化斑块的调控。通过单细胞测序技术，建立扰动流作用下炎性血管中的血管壁细胞亚群和炎症细胞亚群的数据库，提出调控细胞亚群的研究思路；发现新的响应扰动流的效应分子，旗语家族成员Sema7A；揭示Clec2介导血小板在扰动流的作用下向内皮下迁移，参与调控AS斑块的形成；发现血管周围脂肪组织在血管炎症和斑块形成过程中也扮演着重要的作用。同时还建立了小鼠病理血栓模型，对其结构特征以及决定其构成的关键调控因子的研究可能揭开AS血栓形成的机制，发现新的抗血栓靶点。
主持或参加科研项目（课题）及人才计划项目情况（按时间倒序排序）
1. 国家自然科学基金面上项目，82070450，CLEC2-PDPN调控扰动流诱导的血小板-单核细胞聚集体内皮下迁移的机制及转化研究，2021/01-2024/12，55万元，在研，主持。
2. 国家自然科学基金面上项目，81670134， 新型代谢性心血管疾病模式动物仓鼠血栓模型的建立及其在抗血栓药物筛选中的应用，2017/01-2020/12，85万元，已结题，主持。
3. 国家自然科学基金青年项目，31300781，参与扰动血流促进血栓形成信号途径的靶分子的初步筛选，2014/01-2016/12，25万元，已结题。
4. 江苏省基础研究计划（自然科学基金）面上项目，SBK2020021780，扰动流对血管内皮细胞异质性的时空调控及其机制研究，2020/07-2023/06, 10万元，在研，主持。
代表性成果
[1]Chaojun Tang#*, Guona Chen#, Fan Wu#, Yiren Cao#, Fei Yang#, Tao You, Chu Liu, Menglu Li, Shuhong Hu, Lijie Ren, Qiongyu Lu, Wei Deng, Ying Xu, GuixueWang, Hanjoong Jo, Yonghong Zhang, Yi Wu, Brian A. Zabel, and Li Zhu*. Endothelial CCRL2 induced by disturbed flow promotes atherosclerosis via chemerin-dependent β2 integrin activation in monocytes. Cariovascular Research, 2023, accepted.
[2]Qiongyu Lu#, Ziting Liu#, Luyao Zhao#, Linru Xu, Chu Liu, Ling Li, Yiren Cao, Fengchan Li, Lili Wu, Lei Wang, Ting Chen, Tao You, Lijie Ren, Guixue Wang, Chaojun Tang*, Li Zhu*. Sema7A protects against high-fat diet-induced obesity and hepatic steatosis by regulating adipo/lipogenesis. Molecular Metabolism, 2023 Apr; 70: 101698.
[3]Fengchan Li, Yun Du, Lei Hong, Ziting Liu, Kunmin Yan, Chu Liu, Zhen Zhu, Qiongyu Lu, Chaojun Tang*, and Li Zhu*. Single-cell transcriptional profiling of human carotid plaques reveals a subpopulation of endothelial cells associated with stroke incidences. J Cell Mol Med, 2022;26:3446-3459.
[4]Chaojun Tang#, Lei Wang#, Yulan Sheng, Zhong Zheng, Zhanli Xie, Fan Wu, Tao You, Lijie Ren, Lijun Xia, Changgeng Ruan, and Li Zhu*. CLEC-2-dependent platelet subendothelial accumulation by flow disturbance contributes to atherogenesis in mice. Theranostics, 2021 Oct 3;11(20): 9791-9804.
[5]Fengchan Li#, Kunmin Yan, Lili Wu, Zhong Zheng, Yun Du, Ziting Liu, Luyao Zhao, Wei Li, Yulan Sheng, Lijie Ren, Chaojun Tang*, and Li Zhu*. Single-cell RNA-seq reveals cellular heterogeneity of mouse carotid artery under disturbed flow. Cell Death Discov 2021,7:180.
[6]Hong L#, Li F#, Tang C#, Li L, Sun L, Li X and Zhu L*. Semaphorin 7A promotes endothelial to mesenchymal transition through ATF3 mediated TGF-β2/Smad signaling. Cell Death Dis. 2020, 11(8):695.
[7]Lei Wang, Chaojun Tang*.Targeting Platelet in Atherosclerosis Plaque Formation: Current Knowledge and Future Perspectives. Int J Mol Sci. 2020 Dec 21;21(24):9760.
[8]Lijie Ren, Tao You, Qing Li, Guona Chen, Ziting Liu, Xuefei Zhao, Yinyan Wang, Lei Wang, Yi Wu, Chaojun Tang*, Li Zhu*. Molecular docking-assisted screening reveals tannic acid as a natural protein disulphide isomerase inhibitor with antiplatelet and antithrombotic activities, Journal of Cellular and Molecular Medicine, 2020 Oct 30;24(24):14257-14269.
[9]Lei Hong#, Fengchan Li#, Chaojun Tang#, Ling Li, Lili Sun, Xiaoqiang Li*, Li Zhu*. Semaphorin 7A promotes endothelial to mesenchymal transition through ATF3 mediated TGF-β2/Smad signaling, Cell Death Dis, 2020 Aug;11(8):695.
[10]Lijie Ren, Qing Li, Tao You, Xuefei Zhao, Xingshun Xu, Chaojun Tang*, Li Zhu*. Humanin analog, HNG, inhibits platelet activation and thrombus formation by stabilizing platelet microtubules, Journal of Cellular and Molecular Medicine, 2020 Apr;24(8):4773-4783.
[11]Lijie Ren, Lei Wang, Tao You, Yifei Liu, Fan Wu, Li Zhu, Chaojun Tang*. Perivascular adipose modulates carotid plaque formation induced by disturbed flow in mice. J Vas Surg, 2019 Sep;70(3):927-936.e4
[12]Shuhong Hu#, Yifei Liu#, Tao You#, Jack Heath, Linru Xu, Xiaowei Zheng, Aili Wang, Yinyan Wang, Fengchan Li, Fei Yang, Yiren Cao, Huayu Zhang, Janine M. van Gils, Anton Jan van Zonneveld, Hanjoong Jo, Qingyu Wu, Yonghong Zhang, Chaojun Tang*, Li Zhu*. Vascular Semaphorin 7A Upregulation by Disturbed Flow Promotes Atherosclerosis Through Endothelial β1 Integrin. Arterioscler Thromb Vasc Biol. 2018, 38(2):335-343.
[13]Chaojun Tang#*, Yinyan Wang#, Daoxi Lei, Lu Huang, Guixue Wang, Qingjia Chi, Yiming Zheng, Chritian Gachet, Pierre H. Mangin, Li Zhu. Standardization of a well-controlled in vivo mouse model of thrombus formation induced by mechanical injury, Thrombosis Research, 2016, 141:49-57
[14]Mathieu Schaff#, Chaojun Tang#, Eric Maurer, Catherine Bourdon, Nicolas Receveur, Anita Eckly, Béatrice Hechler, Christiane Arnold, Adèle de Arcangelis, Bernhard Nieswandt, Cécile V. Denis, Olivier Lefebvre, Elisabeth Georges-Labouesse, Christian Gachet, MD,François Lanza, Pierre H. Mangin*, Integrin α6β1 is the main receptor for vascular laminins and plays a role in platelet adhesion, activation, and arterial thrombosis, Circulation, 2013, 128(5), 541-552.
[15]Eric Maurer#, Chaojun Tang#, Mathieu Schaff, Catherine Bourdon, Nicolas Receveur, Catherine Ravanat, Anita Eckly, Béatrice Hechler, Christian Gachet, Francois Lanza, Pierre H. Mangin*, Targeting platelet GPIbβ reduces platelet adhesion, GPIb signaling, thrombin generation and prevents arterial thrombosis, Arter Thromb Vasc Biol, 2013, 33:1221-1229.