吴庆宇

教授，博士生导师

 

江苏省苏州市工业园区仁爱路199号703号楼618室
18新利体育 唐仲英血液学研究中心
电话：86-512-65880877/0899
传真：86-512-65880929
Email: wuqy@suda.edu.cn

 

教育背景：

1978年-1982年 苏州医学院 临床医学专业 学士
1982年-1985年 苏州医学院 临床医学专业 硕士
1984年-1985年 巴黎第七大学 生物学专业 硕士
1984年-1988年 巴黎第七大学 生物学专业 博士
1990年-1990年 美国华盛顿大学医学院 博士后

工作经历：

1988年-1989年 18新利体育 血栓室 副主任
1994年-1995年 美国华盛顿大学医学院 讲师
1995年-1998年 美国Berlex生物科学 研究员
1998年-2005年 美国Berlex生物科学 资深研究员
2006年-至今 美国克利夫兰临床医学中心Lerner研究所 教授
2006年-至今 18新利体育 教授

研究领域：

心血管蛋白酶调节血管及心脏功能作用的研究
蛋白酶在生物学中起广泛作用。Corin 是一种具有调节血压和心脏功能的重要蛋白酶，能够激活心脏中的利钠肽, 从而产生利尿、排钠及舒张血管的作用。这一分子机制对控制高血压和心脏病的发生至关重要。我们正在进行的研究有：可溶性Corin 在心力衰竭诊断及治疗中的意义；Corin 的活化机制研究；Corin 基因突变/SNPs 在高血压及心力衰竭发生中作用；Corin 参与高血压、心力衰竭的可能分子机制的研究；此外，我们还研究血栓、止血和心血管生物学领域中的其它一些蛋白酶。

团队成员：

工作人员

董宁征，博士，研究员 [点击进入董宁征个人主页]
刘 萌，博士，副研究员
周田甜，博士，副研究员

研究生

博士研究生：牛亚燕，张先瑞

硕士研究生：陈悦，孙拾进，张沂凯，谷夏冰，都春宇，李文国

 

代表性成果：
 
1. Wang C, Wang Z, He M, Zhou T, Niu Y, Sun S, Li H, Zhang C, Zhang S, Liu M, Xu Y, Dong N*, Wu Q*. Krüppel-like factor 17 upregulates uterine corin expression and promotes spiral artery remodeling in pregnancy. Proc Natl Acad Sci U S A. 2020;117:19425-34.
 
2. Zhang C, Zhang Y, Zhang S, Wang Z, Sun S, Liu M, Chen Y, Dong N*, Wu Q*. Intracellular autoactivation of TMPRSS11A, an airway epithelial transmembrane serine protease. J Biol Chem. 2020: 295:12686-96.
 
3. He M, Zhang Y, Li H, Liu M, Dong N*, Wu Q*. A common CORIN variant in hypertension reduces corin intracellular trafficking by exposing an inhibitory N-terminus. Biochem Biophys Res Commun. 2020;530:35-41.
 
4. Sun S, Wang L, Zhang S, Zhang C, Chen Y, Wu Q, Dong N. N-glycan in the scavenger receptor cysteine-rich domain of hepsin promotes intracellular trafficking and cell surface expression. Int J Biol Macromol. 2020;161:818-27.
 
5. Wang L, Zhang C, Sun S, Chen Y, Hu Y, Wang H, Liu M1, Dong N*, Wu Q*. Autoactivation and calpain-1-mediated shedding of hepsin in human hepatoma cells. Biochem J. 2019;476:2355-69. 
 
6. Yan R, Liu M, Hu Y, Wang L, Wang C, Jiang Y, Zhou Q, Qi X, Dong N*, Wu Q*. Ectopic expression of human airway trypsin-like protease 4 in acute myeloid leukemia promotes cancer cell invasion and tumor growth. Cancer Med. 2019 2019;8:2348–59.
 
7. Hu Y, Li H, Yan R, Wang C, Wang Y, Zhang C, Liu M, Zhou T, Zhu W, Zhang H, Dong N*, Wu Q*: Increased neutrophil activation and plasma DNA levels in patients with preeclampsia. Thromb Haemost 2018;118:2064-73.
 
8. Hu Y, Yan R, Zhang C, Zhou Z, Liu M, Wang C, Zhang H, Dong L, Zhou T, Wu Y, Dong N, Wu Q. High-Mobility Group Box 1 From Hypoxic Trophoblasts Promotes Endothelial Microparticle Production and Thrombophilia in Preeclampsia. Arterioscler Thromb Vasc Biol 2018;38:1381-91.
 
9. Zhou H, Zhu J, Liu M, Wu Q, Dong N.  Role of the protease corin in chondrogenic differentiation of human bone marrow-derived mesenchymal stem cells. J Tissue Eng Regen Med. 2018;12:973-82.
 
10. Zhang Y, Zhou T, Niu Y, He M, Wang C, Liu M, Yang J, Zhang Y, Zhou J, Fukuda K, Qin J, Dong N, Wu Q. Identification and functional analysis of CORIN variants in hypertensive patients. Hum Mutat 2017;38:1700-10.
 
11. Chen S, Wang H, Li H, Zhang Y, Wu Q.  Functional analysis of corin protein domains required for PCSK6-mediated activation. Int J Biochem Cell Biol 2017;94:31-39.
 
12. Zhang Z, Hu Y, Yan R, Dong L, Jiang Y, Zhou Z, Liu M, Zhou T, Dong N, Wu Q: The transmembrane serine protease HAT- like 4 is important for epidermal barrier function to prevent body fluid loss. Sci Rep 2017;7:45262.
 
13. Li H, Zhang Y, Wu Q: Role of corin in the regulation of blood pressure. Curr Opin Nephr Hyertens 2017;26:67-73.
 
14. Dong L, Wang H, Dong N, Zhang C, Xue B, Wu Q:Localization of corin and atrial natriuretic peptide in human renal segments. Clin Sci (Lond) 2016;130:1655-64.
 
15. Chen S, Cao P, Dong N, Peng J, Zhang C, Wang H, Zhou T, Yang J, Zhang Y, Martelli EE, Naga Prasad SV, Miller RE, Malfait AM, Zhou Y, Wu Q. PCSK6-mediated corin activation is essential for normal blood pressure. Nat Med 2015;21:1048-53.
 
16. Zhang Y, Li H, Zhou J, Wang A, Yang J, Wang C, Liu M, Zhou T, Zhu L, Zhang Y, Dong N, Wu Q. A corin variant identified in hypertensive patients that alters cytoplasmic tail and reduces cell surface expression and activity. Sci Rep 2014;4:7378.
 
17. Dong N, Zhou T, Zhang Y, Liu M, Li H, Huang X, Liu Z, Wu Y, Fukuda K, Qin J, Wu Q. Corin mutations K317E and S472G from preeclamptic patients alert zymogen activation and cell surface targeting. J Biol Chem 2014;289:17909-16.
 
18. Sun S, Liu Z, Zhou H, Li G, Liu M, Yao J, Zhou T, An G, Wu Q*, Dong N*. The Role of Fucosylation in the Promotion of Endothelial Progenitor Cells in Neovascularization and Bone Repair. Biomaterials 2014;35:3777-85.
 
19. Gao L, Liu M, Dong N, Jiang Y, Lin C-Y, Huang M, Wu D, Wu Q. Matriptase is highly up-regulated in chronic lymphocytic leukemia and promotes cancer cell invasion. Leukemia 2013;27:1191-4.
 
20. Fang C, Shen L, Dong L, Liu M, Shi S, Dong N, Wu Q. Reduced urinary Corin levels in patients with chronic kidney disease. Clin Sci (Lond) 2013;124:709-17.
 
21. Dong N, Fang C, Jiang Y, Zhou T, Liu M, Zhou J, Shen J, Fukuda K, Qin J, Wu Q. Corin mutation R539C from hypertensive patients impairs zymogen activation and generates inactive alternative ectodomain fragment. J Biol Chem 2013;288:7867-74.
 
22. *Cui Y, *Wang W, *Dong N, *Lou J, Srinivasan D, Cheng W, Huang X, Liu M, Fang C, Peng J, Chen S, Wu S, Liu Z, Dong L, Zhou Y, Wu Q. Role of corin in trophoblast invasion and uterinespiral artery remodeling in pregnancy. Nature 2012;484:246-50.*Co-first authors
 
23. Qi X, Jiang J, Zhu M, Wu Q. Human corin isoforms with different cytoplasmic tails that alter cell surface targeting. J Biol Chem 2011;286:20963-9.
 
24. Dong N, Chen S, Yang J, He L, Liu P, Zheng D, Li L, Zhou Y, Ruan C, Plow E, Wu Q. Plasma soluble corin in patients with heart failure. Circ Heart Fail 2010;3:207-11.
 
25. Bugge T, Antalis T, Wu Q. Type II transmembrane serine proteases. J Biol Chem 2009;284:23177-81.
 
26. Wang W, Liao X, Fukuda K, Knappe S, Wu F, Dries DL, Qin J, Wu Q. Corin variant associated with hypertension and cardiac hypertrophy exhibits impaired zymogen activation and natriuretic peptide processing activity. Circ Res 2008;103:502-8.
 
27. Liao X, Wang W, Chen S, Wu Q. Role of glycosylation in corin zymogen activation. J Biol Chem 2007;282:27728-35.
 
28. Chan J, Knudson O, Wu F, Morser J, Dole WP, Wu Q. Hypertension in mice lacking the pro-atrial natriuretic peptide convertase, corin. Proc Natl Acad Sci USA 2005;102:785-90.
 
29. Wu F, Wu Q. Corin-mediated processing of pro-atrial natriuretic peptide in human small cell lung cancer cells. Cancer Res 2003;63:8318-22.
 
30. Yan W, Wu F, Morser J, Wu Q. Corin, a transmembrane cardiac serine protease, acts as a pro-atrial natriuretic peptide converting enzyme. Proc Natl Acad Sci USA 2000;97:8525-29.