Zhen Wu†, Dongping Wang†, Yuan Liu†, Leitao Huan†, and Chen Zhu*†（朱晨）
† Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, 199 Ren-Ai Road, Suzhou, Jiangsu 215123, China
J. Am. Chem. Soc., 2017, 139 (4), pp 1388–1391
Herein we report a novel, general protocol for distal heteroaryl ipso-migration and its application to the elusive heteroarylation of unactivated alkenes. A set of nitrogen-containing heteroaryl groups showcase the migratory aptitude. This reaction provides a variety of fluoroalkyl functionalized heteroarenes under mild reaction conditions. This is the first report of a difunctionalization of unactivated alkenes with distal heteroaryl migration.
链接：http://pubs.acs.org/doi/abs/10.1021/jacs.6b11234