Rare Earth Amide-Catalyzed Direct Thioesterification of Aldehydes with Thiols under Mild Conditions
Nadia Ismaeel1, Sajid Imran1, Xuehua Zhu2, Jue Chen,3*（陈珏） Dan Yuan1*（袁丹）, and Yingming Yao1*（姚英明）
1 Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Dushu Lake Campus, Soochow University, Suzhou 215123, People’s Republic of China
2School of Chemistry and Life Science, Suzhou University of Science and Technology, Suzhou 215009,People’s Republic of China
3School of Biological and Chemical Engineering, Ningbo Tech University, Ningbo 315100, People’s Republic of China
Org. Lett. 2023, 25, 8672−8676
Abstract: Direct thioesterification of aldehydes with thiols catalyzed by readily accessible rare earth/lithium amide RE[N-(SiMe3)2]3(μ-Cl)Li(THF)3 is developed, which enables the preparation of a range of thioesters (31 examples) under room temperature and solvent-free conditions, without using any additive or external oxidant. This method provides a straightforward and atom-efficient approach for the thioester synthesis.
链接：https://pubs.acs.org/doi/10.1021/acs.orglett.3c03497